A5015702514- Lung Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Medical Imaging and Pathology Studies
- Cardiac Arrhythmias and Treatments
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Cardiac and Coronary Surgery Techniques
- Endometriosis Research and Treatment
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Intraperitoneal and Appendiceal Malignancies
- Sarcoma Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Angiogenesis and VEGF in Cancer
- Pleural and Pulmonary Diseases
- Cardiac pacing and defibrillation studies
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
Tohoku Medical and Pharmaceutical University Hospital
2017-2024
Tohoku Medical and Pharmaceutical University
1994-2023
Tohoku Medical and Pharmaceutical University Wakabayashi Hospital
2019-2022
Osaka City General Hospital
2010-2022
Komatsu (Japan)
2021
Kindai University
2008-2020
Kanazawa University
1997-2018
Tohoku University Hospital
2014-2018
Tohoku University
2014-2017
Yokohama City University
2016
In a previous phase 3 trial of adjuvant chemotherapy after resection non–small-cell lung cancer, combination uracil and tegafur (often referred to as UFT) taken orally was shown prolong survival. A subgroup analysis disclosed that most patients who benefited had pathological stage I adenocarcinoma.
The vascular endothelial growth factor (VEGF) family is a novel regulator of cell proliferation. We assessed the mRNA expression VEGF, VEGF type C (VEGF-C) and their receptors together with microvessel density (VD) microlymphatic vessel (LVD) in pursuit connection prognostic value malignant pleural mesothelioma (MPM). used four human MPM lines, 54 tumours five normal tissues. Expression levels for ligands were by semiquantitative reverse transcriptase polymerase chain reaction analysis....
We have identified a novel membrane-type matrix metalloproteinase (MT-MMP) expressed on the cell surface and inducing activation of pro-gelatinase A in vitro. In this study, we further examined possibility that MT-MMP is activator tumors as well Expression mRNA was analyzed by Northern blotting 58 cases human lung carcinomas. expression increased tumor tissues compared with adjacent normal tissues. The ratio levels tumor/normal (T/N ratio) 3.19 +/- 1.62 29 adenocarcinoma, 3.09 1.44 24...
Purpose The objective of this study was to assess clinical outcomes and fertility in patients treated conservatively for unilateral stage I invasive epithelial ovarian cancer (EOC). Patients Methods A multi-institutional retrospective investigation undertaken identify with EOC fertility-sparing surgery. Favorable histology defined as grade 1 or 2 adenocarcinoma, excluding clear cell histology. Results total 211 (stage IA, n = 126; IC, 85) were identified from 30 institutions. Median duration...
Only a subset of cervical precursor lesions progress to cancer and because the lack predictive markers, it cannot be ascertained which will or not. To estimate risk disease progression associated with human papillomavirus (HPV) genotypes, we followed 570 Japanese women cytological LSIL (low-grade squamous intraepithelial lesion) histological CIN (cervical neoplasia) grade 1-2 (479 1; 91 2) at 3 4 month intervals for mean follow-up period 39.1 months. At entry, detected HPV DNA in samples by...
Introduction BRCA gene mutations are associated with hereditary ovarian cancer. plays a key role in genome integrity, and result an increased risk for Although various guidelines recommend testing patients cancer, data on germline (g B RCA ) mutation frequency cancer Japan scarce. Objective This study aimed to determine g BRCA1/2 Japanese stratified by clinicopathological characteristics, assess patients’ satisfaction pre-test genetic counseling. Methods The CHARLOTTE (CHARacterizing the...
S100A4 has been implicated in the malignant phenotype of tumor cells, including cell motility, but biological function is hardly known. A recent study suggests that S100A4-induced invasiveness cells partially caused by down-regulation E-cadherin. To clarify clinical significance and its association with E-cadherin-mediated cell-to-cell adhesion system, we examined their protein expressions non-small lung cancer (NSCLC) specimens using immunohistochemical techniques. Expression was observed...
A streptococcal preparation, OK-432 was employed as the adjuvant immunotherapeutic agent for lung cancer. To evaluate clinical efficacy of OK-432, patients admitted between 1975 and 1979 were randomized into two groups: (1) an immunochemotherapy group (2) a chemotherapy, or control, group. For evaluation long-term survival, there 108 cases in 103 chemotherapy When comparing prognosis groups, survival rate statistically higher than control The resected Stages I II showed better with same...
The efficacy of taxane plus platinum regimens has been demonstrated for advanced or recurrent endometrial cancer; however, it not assessed in postoperative adjuvant chemotherapy cancer.To evaluate the clinical benefit compared with standard doxorubicin cisplatin as cancer.In this multicenter, open-label, phase 3 randomized trial, patients cancer at high-risk stage I II III IV that did extend beyond abdominal cavity and had 2 cm greater residual tumor were included from 118 institutions Japan...
By fractionation using polyacrylamide gel electrophoresis and/or a preparative hybrid selection method employing solid-phase DNA probes, we prepared and characterized mitochondrial tRNAs from the body wall muscle of Ascaris suum, all which are thought to lack either T stem or D their gene sequences (Okimoto, R., Wolstenholme, D. R. (1990) EMBO J. 10, 3405-3411). Some partially purified were appreciably aminoacylated with an extract A. suum mitochondria. The three species sequenced had CCA...
Diffuse brainstem glioma has a poor prognosis, and there are few long-term survivors. We looked for clinical, conventional magnetic resonance (MR), MR spectroscopic (MRS) findings predictive of the prognosis patients with glioma. Our institutional review board approved this retrospective study 23 diffuse intrinsic pontine or medullary treated during period 2000–2009. To evaluate prognostic values, we performed Kaplan-Meier survival analysis (log-rank test) that incorporated patients' age...
Mature cystic teratoma (MCT) of the ovary rarely undergoes malignant transformation (MT). Malignant carries a significantly worse prognosis than epithelial ovarian cancer, regardless whether postoperative chemotherapy or radiotherapy is applied. The rarity this tumor has posed significant challenge to developing standardized management protocols. aim study was review our experience with MT and describe current treatment practices.A retrospective chart these patients performed that identified...