A5008584298- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Brain Metastases and Treatment
- Testicular diseases and treatments
- Advanced Neuroimaging Techniques and Applications
- Ion channel regulation and function
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Chromatin Remodeling and Cancer
- MicroRNA in disease regulation
- Spinal Dysraphism and Malformations
- Medical Imaging Techniques and Applications
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Hedgehog Signaling Pathway Studies
- Congenital Heart Disease Studies
- Teratomas and Epidermoid Cysts
- Microtubule and mitosis dynamics
- Ocular Oncology and Treatments
Hiroshima University
2013-2024
The University of Texas Health Science Center at Houston
2019-2022
Hiroshima University Hospital
2011-2022
Kanazawa University
2001
Asahikawa Medical College Hospital
1955
All the experiments were performed on rabbits.1. When γ-aminobutyric acid was injected intravenously, it caused a fall of blood pressure and some changes in respiration.The thresholdal dose affecting less than 70 γ/kg. body weight.The effect increased linearly with logarithm its concentration. But, very high concentrations, decreased.The optimal 8-12 mg/kg. weight.2.β-alanine δ-aminovaleric also pressure. their doses much larger those acid.ε-aminocaproic had only slight α-amino acids no...
Abstract The gut microbiome is fundamental in neurogenesis processes. Alterations microbial constituents promote inflammation and immunosuppression. Recently, immune-oncology, specific taxa have been described to enhance the effects of therapeutic modalities. However, dysbiosis on glioma are still unknown. aim this study was explore development Temozolomide (TMZ) fecal mice humans. C57BL/6 were implanted with GL261/Sham given TMZ/Saline. Fecal samples collected longitudinally analyzed by 16S...
Diffuse brainstem glioma has a poor prognosis, and there are few long-term survivors. We looked for clinical, conventional magnetic resonance (MR), MR spectroscopic (MRS) findings predictive of the prognosis patients with glioma. Our institutional review board approved this retrospective study 23 diffuse intrinsic pontine or medullary treated during period 2000–2009. To evaluate prognostic values, we performed Kaplan-Meier survival analysis (log-rank test) that incorporated patients' age...
BACKGROUND AND OBJECTIVES: Maximizing the extent of resection (EOR) improves outcomes in glioblastoma (GBM). However, previous GBM studies have not addressed EOR impact molecular subgroups beyond IDH1/IDH2 status. In current article, we evaluate whether confers a benefit all subtypes or only particular subgroups. METHODS: A retrospective cohort newly diagnosed isocitrate dehydrogenase (IDH)–wildtype undergoing were prospectively included database (n = 138). and residual tumor volume (RTV)...
The differentiation of malignant lymphomas from gliomas or by conventional MRI can be difficult. authors studied Gd-enhanced MR images to obtain a differential diagnosis between and without central necrosis cystic changes investigated the diagnostic value single-voxel proton spectroscopy ((1)H-MRS) using different parameters, including lipid levels.This was retrospective study patients with primary CNS lymphoma (n = 17) glioma 122 [Grades I, II, III, IV in 10, 30, 33, 49 patients,...
OBJECTIVE Currently, the standard treatment protocol for patients with newly diagnosed glioblastoma (GBM) includes surgery, radiotherapy, and concomitant adjuvant temozolomide (TMZ). Various prognostic biomarkers GBM have been described, including survivin expression. The aim of this study was to determine whether subcellular localization correlates prognosis in who received protocol. METHODS authors retrospectively examined (nuclear, cytoplasmic, or both) using immunohistochemistry 50 had...
Abstract BACKGROUND Brain metastases (BMs) occur in ∼1/3 of cancer patients and are associated with poor prognosis. Genomic alterations contribute to BM development; however, mutations that predispose promote development poorly understood. OBJECTIVE To identify differences genomic between primary tumors. METHODS A retrospective cohort 144 were tested for (85 lung, 21 breast, 14 melanoma, 4 renal, colon, 3 prostate, others, 9 unknown carcinomas) by a next-generation sequencing assay...
OBJECTIVE Glioblastoma differentials include intracranial tumors, like malignant lymphomas and metastatic brain tumors with indiscernible radiological characteristics. The purpose of this study was to identify a distinct feature for the preoperative differentiation glioblastoma from its differentials, which tumors. METHODS Preoperative MR images, including diffusion-weighted imaging (DWI) studies (b = 1000 4000 sec/mm 2 ), obtained in patients newly diagnosed tumor, were analyzed...
<b><i>Introduction:</i></b> The interaction of K27M mutation in histone H3 (H3K27M mutation) with polycomb repressive complex 2 (PRC2) is facilitated by the enhancer zeste homolog (EZH2). Subsequently, this leads to global reduction level H3K27me3. We analyzed EZH2 expression H3K27M mutation-positive tumors and revealed association high poor survival. <b><i>Methods:</i></b> Our study included 12 patients, an age range 6–56 years treated between...
Abstract Serum and cerebrospinal fluid (CSF) levels of α-fetoprotein β-subunit human chorionic gonadotropin are used as biomarkers for the management central nervous system (CNS) germ cell tumors (GCTs). However, additional discriminating required. Especially, to differentiate non-germinomatous (NGGCTs) from germinomas critical, these have a distinct prognosis. We investigated CSF samples 12 patients with CNS-GCT (8 4 NGGCTs). analyzed circulating tumor DNA (ctDNA) in detect mutated genes....
Multicentric gliomas are very rare. Due to differences in their tumor types they remain enigmatic. We focused on the pathogenesis of multicentric and compared immunoprofile with that solitary gliomas. This retrospective study included 6 males 8 females glioma (8 glioblastomas, 2 anaplastic astrocytomas, 4 diffuse astrocytomas). Their age ranged from 27 75 years all were treated between 2004 June 2015. The expression mutant isocitrate dehydrogenase 1 (IDH1), α-thalassemia X-linked...
Arachnoid cysts are well known to induce chronic subdural hematoma (CSDH) after head injury. However, histological observations of the arachnoid cyst and membrane have only been rarely described. An 8-year-old boy a 3-year-old presented with CSDH associated cyst. Surgical removal biopsy wall were performed. Clinical courses good without recurrence more than 1.5 years surgery. Histological examination suggested that did not contribute development. Pediatric membranes, similar adult key in...