OBJECTIVE Glioblastoma differentials include intracranial tumors, like malignant lymphomas and metastatic brain tumors with indiscernible radiological characteristics. The purpose of this study was to identify a distinct feature for the preoperative differentiation glioblastoma from its differentials, which tumors. METHODS Preoperative MR images, including diffusion-weighted imaging (DWI) studies (b = 1000 4000 sec/mm 2 ), obtained in patients newly diagnosed tumor, were analyzed...

<b><i>Introduction:</i></b> The interaction of K27M mutation in histone H3 (H3K27M mutation) with polycomb repressive complex 2 (PRC2) is facilitated by the enhancer zeste homolog (EZH2). Subsequently, this leads to global reduction level H3K27me3. We analyzed EZH2 expression H3K27M mutation-positive tumors and revealed association high poor survival. <b><i>Methods:</i></b> Our study included 12 patients, an age range 6–56 years treated between...

Background: The current World Health Organization (WHO) 2021 classification of human glioma is based on key molecular biomarkers to define neoplastic entities. This review further delineates mutant IDH (isocitrate dehydrogenase) from wild-type disease, a necessity given the large survival gap between and tumors. In Indonesia, there are currently few reports distribution significance these mutations. Therefore, this research aims determine relationship mutations, as well clinicopathological...

Multicentric gliomas are very rare. Due to differences in their tumor types they remain enigmatic. We focused on the pathogenesis of multicentric and compared immunoprofile with that solitary gliomas. This retrospective study included 6 males 8 females glioma (8 glioblastomas, 2 anaplastic astrocytomas, 4 diffuse astrocytomas). Their age ranged from 27 75 years all were treated between 2004 June 2015. The expression mutant isocitrate dehydrogenase 1 (IDH1), α-thalassemia X-linked...

Concurrent multiple tumors developing in the spinal cord are rare, except for genetic disorders, such as neurofibromatosis and von Hippel-Lindau disease. Furthermore, concurrent arising same level with discrete histopathology much rarer. We report two cases. Case 1: A 53-year-old man presented intracranial hemorrhage that manifested disturbed consciousness right hemiparesis. Magnetic resonance (MR) angiography demonstrated severe stenosis of terminal portion bilateral internal carotid...

Type 2 diabetes mellitus (T2DM) is an age‑related disease associated with cerebral inflammation and Alzheimer's disease. <em>Garcinia mangostana</em> pericarp (GMP) possesses antihyperglycemic, antidiabetic anti‑inflammatory effects. The aim of the present study was to evaluate effect GMP extract on in Wistar rats T2DM by examining expression levels glial nuclear factor‑κB (NF‑κB), interleukin (IL)‑6, tumor necrosis factor‑α (TNF‑α) superoxide dismutase (SOD). A total 36 8‑10‑week‑old male...

Background: Associated with sepsis is the illness known as acute kidney injury (AKI). AKI may be mediated by uric acid, and blood creatinine levels can utilized to diagnose condition measure function. Sambiloto (Andrographis paniculata) a traditional medicine that has flavonoid compounds reduce Xanthine Oxidase Inhibitors which acid levels.Objective: Septic model rats generated lipopolysaccharide were used test effects of sambiloto leaf extract on serum (LPS).Methods: This study was...

Non-alcoholic fatty liver disease (NAFLD) patients have alteration in hemostasis components. Thus, including excess expression of plasminogen activator inhibitor-1 (PAI-1), causing fibrinolysis disorders; the majority these are hypercoagulable state prone to thrombosis. Some evidence suggests that garlic and supplements antithrombotic anti-inflammatory properties. Besides, stimulates fibrinolytic activity normalizes plasma lipid imbalances. Black is processed produced through natural aging...

Purpose This paper aims to determine the effect of black garlic (BG) on visceral fat, oxidative stress and insulin resistance (IR) compared with metformin vitamin E in nonalcoholic fatty liver disease (NAFLD) rats. Design/methodology/approach A randomized post-test only design control group was used this study. Rats were given high-fat fructose diet enriched 1.25% cholesterol 0.5% cholic acid for eight weeks induce NALFD condition. The administration BG dose 450 mg/200 gBW, 900 gBW 1350 a...

Latar Belakang: Sekitar 30-50% karsinoma payudara positif terhadap virus Epstein-Barr (EBV). Studi melaporkan bahwa EBV cenderung lebih agresif. Infeksi dapat dibuktikan salah satunya melalui pemeriksaan LMP1. Sejauh ini studi tentang infeksi karakteristik klinikopatologis di negara-negara Asia termasuk Indonesia masih terbatas. Penelitian bertujuan menganalisis hubungan ekspresi LMP1 dengan invasif.Metode: cross-sectional menggunakan 64 sampel blok parafin dari pasien invasif RSUP Dr....

Background: Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal and paranasal sinuses mucosa that takes place for more than 3 months. The treatment paradigm nowadays depends on Functional Endoscopic Sinus Surgery (FESS) in hope to repair damaged mucosa, restoring it its physiological condition. Hyaluronic Acid (HA) could restore natural barrier stop cascade. Purpose: To understand difference number cells post-FESS CRS patients had been treated with HA. Method: This...

Introduction: The main objective of the surgical procedure is to achieve maximum resections with minimal functional neurological deficits for patient intrinsic tumors near eloquent cortical area. awake craniotomy currently key option achieving optimum safe resection. We report our two years experience in establishing an Kariadi General Hospital, evaluating adoption technique and outcome surgery.Methods: This a retrospective study analyzed data from all patient's medical records, who have...

Mangosteen peel extract is a xanthone group, that plays an important role in anti-angiogenesis. This study investigated mangosteen on cerebral neovascularization type 2 diabetes mellitus (DM) rats. used 36 rats, randomized into six groups: C1 (negative control); C2 (high fat diet (HFD) and at 200 ㎎/㎏ BW); C3 (HFD diabetic); E1, E2, E3 (HFD, diabetic, 100, 200, 400 BW respectively). All groups were measured body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR) β...

ABSTRACTBackground: Obesity is a disorder or disease characterized by the accumulation of excess fat in body due to an imbalance energy intake that used for long time. Accumulation can reduce adiponectin, causing cardiac hypertrophy, endothelial vasodilation, and other cardiovascular diseases. Black garlic have high antioxidants form S-Allylcysteine(SAC) which functions increase adiponectin. Objective: To determine effect on histopathological picture heart aorta obese rats. Methods: This...

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin in Asia and Indonesia. DLBCL could be further classified according to cell origin as germinal center (GCB) subtype or non-germinal (non-GCB) subtypes; these, non-GCB usually has poorer prognosis. The purpose this study determine relationship between cell-origin 3-year overall survival patients with at Kariadi General Hospital Semarang.This research represents an observational analytical 36 who visited January August...

Background: Even with optimized anti-epileptic medications, 30% of epilepsy patients will be refractory and this condition leads to cognitive psychosocial decline, resulting in worse quality life higher mortality. With 0,75% prevalence, there are more than 2.0 million epileptic Indonesia, about 360.000 refractory, half them potential candidates for surgery (ES). After 17 years since the first ES on July 1999, number increases every year reaching around 50 cases per year. By end 2017, Â total...

Undifferentiated carcinoma is a subtype of NPC with higher EBV antibody titer than healthy people. The carcinogenic effect involves LMP-1 associated poor prognosis, and mutant p53 predicts tumor recurrence. This study aims to assess the on prognosis patients. 40 paraffin blocks were stained mutant. was positive when cytoplasm cell membranes brown, for brown nucleus. Pearson correlation test performed. Most respondents in age group years, males, regional lymph node involvement (N) N1, no...

Inflammation in colonic tissue is one of the earliest developmental pathways colorectal cancer and proteins such as cyclooxygenase are crucial to this inflammation. Batu bananas kepok contain resistant starch which can inhibit inflammation COX-2 mice colon that induced by Azoxymethane Dextran Sodium Sulfate. This study was observe effect banana flour on enzyme tissue. involved 20 BALB/c 4 groups, negative control group, positive batu treatment group. The level seen from treated with...

BackgroundNasopharyngeal carcinoma (NPC) is a malignancy with high incidence in Indonesia. Recent studies had found several factors that influence the and prognosis of NPC including age, sex, histopathological type. This study aimed to determine relationship between age sex type NPC.MethodsSubjects were patients diagnosed by Anatomical Pathology Department Dr. Kariadi General Hospital Medical Center (RSUP Kariadi) from 1st January 2017-31st December 2019. Data collected medical record. The...