A5060164109- Medicinal Plant Research
- Public Health and Nutrition
- Inflammatory Biomarkers in Disease Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Healthcare Quality and Satisfaction
- Natural Antidiabetic Agents Studies
- COVID-19 Clinical Research Studies
- Agricultural and Biological Research
- Food and Agricultural Sciences
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Vitamin D Research Studies
- Diet and metabolism studies
- COVID-19 Prevention and Impact
- Bioactive Compounds in Plants
- Inflammation biomarkers and pathways
- Oral microbiology and periodontitis research
- S100 Proteins and Annexins
- Andrographolide Research and Applications
- Sepsis Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Cancer, Lipids, and Metabolism
- Antibiotic Use and Resistance
- Pharmacology and Nanomedicine Research
Diponegoro University
2019-2024
University of Indonesia
2024
Dr. Kariadi Hospital
2021-2023
Institute of Clinical Research
2021
Social media is currently widely used to disseminate various kinds of information, whether expressing feelings, or opinions. Public opinion no exception regarding government policies and the implementation emission tests, which describe conditions that exist in society. Information on public data obtained through social real time can assist evaluating improving quality implemented policies, particularly tests motorized vehicles. In this research, application stance analysis evaluate test...
More than 25% of women have complaints related to breast lumps during their lifetime and approximately 12% cancer. Cancer antigen 15-3 homocysteine can be used as biomarkers in Breast cancer produces pro-inflammatory cytokines that lead increased CA levels serum levels. Objective: To investigate the differences between patients with benign tumors Methods: Observational analytic study a cross-sectional approach 30 tumor 31 patients. Measurement using enzyme linked immunofluorescent assay...
Link of Video Abstract: https://www.youtube.com/watch?v=RG95aJkUndg Background: Thalassemia and hemoglobinopathies are caused by mutations in the globin genes that reduce haemoglobin synthesis. In many Asian countries, including Indonesia, thalassemia is a common inherited disorder. has specific characteristics due to wide variability from various populations. Therefore, screening protocol should be designed on populations’ regional gene mutation patterns. This study aims investigate...
Latar Belakang : Penentuan kadar glukosa darah menjadi salah satu tolak ukur penting dalam diagnosis diabetes mellitus. Rekomendasi dari WHO menyatakan bahwa sebaiknya disentrifugasi sebelum 30 menit setelah dialirkan ke tabung dan diperiksa sesegera mungkin. Sejumlah penelitian memiliki hasil tidak konsisten mengenai efektivitas natrium fluorida sebagai agen antiglikolitik. Tujuan Membuktikan perbedaan serum plasma (NaF). Metode Penelitian ini adalah deskriptif analitik dengan rancangan...
Latar Belakang : Daun trembesi merupakan salah satu tanaman yang banyak di Indonesia mempunyai kandungan antimikroba. Sediaan hand sanitizer bentuk sediaan dapat digunakan sebagai antiseptik. Tujuan: Mengetahui efek ekstrak daun antiseptik dalam Metode: diekstraksi kemudian dibuat menjadi gel dengan konsentrasi 8% dan 10% ditambahkan aroma anggur. Kemudian, dilakukan uji untuk mengetahui daya dari tersebut serta evaluasi seperti organoleptik, pH, homogenitas. Hasil: Hasil gel, menunjukkan...
Latar Belakang : Diabetes melitus tipe 2 merupakan salah satu masalah kesehatan yang serius dan 1 dari 4 penyakit tidak menular angka kejadiannya terus bertambah ditandai dengan inflamasi kronik karena terjadi resistensi insulin sehingga kadar glukosa darah meningkat. Kondisi tinggi menyebabkan pembentukan radikal bebas timbul stres oksidatif memicu proses inflamasi. Proses dapat meningkatkan sitokin proinflamasi mempengaruhi leukosit, neutrofil limfosit dalam darah. Tujuan Membuktikan...
Latar Belakang: Penggunaan antibiotik yang tidak tepat dapat meningkatkan kejadian resistensi pada akhirnya morbiditas, mortalitas, dan biaya kesehatan. WHO telah merekomendasikan untuk dilakukan kajian rasionalitas penggunaan dalam rangka mengatasi masalah antibiotik.
 Tujuan: Menganalisis kualitas kuantitas di instalasi rawat inap Rumah Sakit Nasional Diponegoro (RSND).
 Metode: Penilaian berdasarkan DDD/100 pasien–hari kriteria van der Meer–Gyssens. Penelitian secara...
Background: Associated with sepsis is the illness known as acute kidney injury (AKI). AKI may be mediated by uric acid, and blood creatinine levels can utilized to diagnose condition measure function. Sambiloto (Andrographis paniculata) a traditional medicine that has flavonoid compounds reduce Xanthine Oxidase Inhibitors which acid levels.Objective: Septic model rats generated lipopolysaccharide were used test effects of sambiloto leaf extract on serum (LPS).Methods: This study was...
Background: C-reactive protein (CRP) and ferritin are acute-phase reactants that have demonstrated association with the severity of a variety inflammation-mediated illnesses, including infection sepsis. Sambiloto (Andrographis paniculata) leaf is traditionally used as an anti-inflammation anti-bacterial herb. extract possesses anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant activitiesObjective: To evaluate effect on inflammation biomarker (CRP serum ferritin) in...
Introduction: Bacterial infection induces inflammation in human body. This process produceshumoral and cellular immune responses. Cinnamomum burmanii grows very vast Indonesia contains cinnamaldehyde known to have an anti-inflammatory effect. Objective : To prove the effect of C. bark extract on CRP level, leukocyte count differential blood count. Methods: Aposttest-only controlled group design with 25 Wistar Rats divided into 5 groups was employed. The CN-G giventhe standard feed, CP-G...
To prove the correlation between VCAM-1 level and absolute monocyte count among Coronary Artery Disease (CAD) patients. The study was an observational analytic with a cross-sectional approach. research subjects were 74 CAD patients who had been proven by coronary angiography treated in Cardiology Department of Central General Hospital Dr. Kariadi Semarang. This conducted from March to July 2021. levels examined ELISA method, using BioTek ELX800 Microplate reader (USA), analyzed flow...
Immature/total neutrophils (I/T) ratio is a simple and inexpensive method used as an early sign of bacterial infection. Meanwhile, the S100B protein found in glial cells functions neuroprotection. Then, interleukin-10 cytokine acts anti-inflammatory during In addition, NEWS2 score to see fast changes patients with sepsis. The purpose study was prove correlation between I/T ratio, S100B, IL-10, A cross-sectional conducted on 34 sepsis from September 2020 February 2021. calculated 100...
BACKGROUND: Hyperglycemia causes dyslipidemia in type 2 diabetes mellitus (T2DM). Metformin monotherapy is known to be less effective at improving glycemic status, insulin function, and lipid profiles. Lycopene a potential antioxidant has been shown hypoglycemic hypocholesterolemic. However, the effects lycopene metformin combination are still up for debate. This study was conducted determine of enhancing ability improve resistance, beta cell capacity, profile T2DM rats.METHODS: Thirty male...
Vitamin D [25(OH)D3] levels are currently associated with clinical inflammatory markers such as C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR). They used to monitor the development of cervical cancer. Aim this study was analyze correlation vitamin NLR values CRP in cancer patients. is expected be an alternative treatment for This analytical observational a cross-sectional design conduct at Dr. Kariadi Hospital Semarang January-March 2024. level measured using enzyme-linked...
Background: Leptin and tumor necrosis factor alpha (TNF-α) are the main adipokine products of adipose tissue, leptin is a hormone that controls appetite, while TNF-α acts as proinflammatory cytokine can cause Insulin resistance levels influenced by body mass inde (BMI). Objective: To prove differences in between T2DM patients with without obesity. Material Method: A cross-sectional study was conducted on 31 subjects obesity 29 DMT2 were measured using enzyme linked immunosorbent assay...
Introduction: Obesity is one of global epidemic health problems. has been suggested to be associated with a state chronic low-grade inflammation, which characterized by abnormal cytokine production, increased acutephase reactants and activation inflammatory signaling pathways. NLR (neutrofil lymphocyte ratio) simple reliable indicator have reported associatied metabolyc syndrom, insulin resitence, obeity in more study. Ferritin marker inflammation contribute obesity, that ferritin rather...
Background: Hemoglobin H (HbH) disease is alpha thalassemia characterized by inactivation of three four α-globin genes due to deletions with or without non-deletional α-thalassemia. Hb Quong Sze (Hb QS) a very rare α-thalassemia in Indonesia caused CTGLeu>CCGPronucleotide substitution at codon 125 α2 globin gene generating highly unstable hemoglobin. Compound heterozygosity for QS and Southeast Asian double deletion (--SEA) result accumulation b-globin tetramers, causing hemolytic...
Latar Belakang : Diabetes melitus merupakan kumpulan gejala gangguan metabolik dengan prevalensi penyandang yang masih terus meningkat. Faktor lingkungan, gaya hidup, maupun genetik dapat menyebabkan kerusakan sel pankreas resistensi insulin kemudian bermanifestasi sebagai diabetes melitus. Daun wungu (Graphytophyllum pictum (L.) Griff) mengandung metabolit aktif seperti flavonoid antioksidan untuk mencegah destruksi dan meregenerasi penderita Tujuan Membuktikan adanya perbedaan ukuran luas...
Coronavirus 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2). Inflammation occurs when the body infected with virus. Platelets play a role in immune response and immunomodulation activating P-Selectin Glycoprotein (PSGL) to site of inflammation. Lymphocytes through CD4 T-cells, B-cells producing specific viral antibodies, CD8 cytotoxic T-cells directly killing virus cells. This study aimed prove correlation between PLR CRP as inflammation...
Background: Stroke is the leading cause of disability and second-most death in Indonesia, caused by atherosclerotic obstructions cerebral cervical arteries. C-reactive protein (CRP) an acute-phase synthesized after stimulation pro-inflammatory cytokines. Vascular cell adhesion molecule 1 (VCAM-1) a sign both inflammation atherosclerosis. S100B dominant central nervous system released event brain, such as stroke. CT-scan gold-standard diagnosis non-hemorrhagic However, it has limit to onset...
Latar Belakang : Pencemaran timbal merupakan salah satu masalah yang sulit dikendalikan berbagai negara karena pencemarannya bisa melalui udara, tanah, makanan dan minuman. Kadar tinggi dalam tubuh menyebabkan peningkatan radikal bebas. Radikal bebas akan merusak sel organ terutama hepar. Sel hepar rusak melepaskan enzim SGOT SGPT darah. Daun kumis kucing mengandung flavonoid sebagai antioksidan bermanfaat menetralisir membantu mengurangi kerusakan pada Tujuan Membuktikan pengaruh pemberian...
Background: Obesity is excessive and abnormal fat accumulation thus harmful to health. Increase in body mass index (BMI) obesity, also accompanied by increase hormon which synthesized released adipose tissue informs the brain for controlling hunger food intake that Leptin. Leptin plays a role chronic inflammatory process of obesity. receptor was detected human platelets high concentration leptin reported promote platelet aggregation. The parameters examination cheap, easy, routinly done...
Background: Indonesia is located in the global thalassemia belt region, with major prevalence that increase every year. Ineffective erythropoiesis (IE) a condition commonly found thalassemia. An lactate dehydrogenase (LDH) level and Activin A was patient, caused by ineffective other factors. However until now, there still no known studies compare LDH non-thalassemia. The aim of study to evaluate difference between non-thalassemia.Methods: observational analytical cross sectional design...