A5100334181- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Cancer and Skin Lesions
- Colorectal Cancer Treatments and Studies
- Single-cell and spatial transcriptomics
- Genomic variations and chromosomal abnormalities
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Salivary Gland Tumors Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Gene expression and cancer classification
- Neuroendocrine Tumor Research Advances
- Ear and Head Tumors
- Gastric Cancer Management and Outcomes
- Glioma Diagnosis and Treatment
- Advanced Biosensing Techniques and Applications
- Metastasis and carcinoma case studies
- Radiomics and Machine Learning in Medical Imaging
- AI in cancer detection
The University of Texas MD Anderson Cancer Center
2016-2025
Guangdong Medical College
2023
Royal Marsden Hospital
2023
Sun Yat-sen Memorial Hospital
2023
Sun Yat-sen University
2023
St. Martin de Porres Hospital
2023
Allegheny General Hospital
2021
McMaster University
2021
Fondazione IRCCS Istituto Nazionale dei Tumori
2021
University of Kansas Medical Center
2021
BACKGROUND The use of cytology specimens for next‐generation sequencing (NGS) is particularly challenging because the unconventional substrate smears and often limited sample volume. An analysis factors affecting NGS testing in cytologic samples may help to increase frequency successful testing. METHODS This study reviewed variables associated with all in‐house cases (n = 207) that were analyzed by Ion Torrent platform during a 10‐month interval. A statistical was performed measure effects...
Abstract Purpose: Trastuzumab deruxtecan (T-DXd) is currently approved for treating metastatic breast cancer (MBC) which HER2-positive (immunohistochemistry [IHC] score of 3+ or ISH positivity) HER2-low (IHC 1+ IHC 2+/ISH negative), as well gastric cancer, HER2-mutant lung and HER2 overexpressing solid tumors. Given the increasing utilization T-DXd, we sought to determine how receptor status might change following T-DXd therapy. Design: We retrospectively reviewed patients with MBC who...
Despite advance on antifungal therapy in the past decade, issues of fungal resistance and a lack effective treatments are still major concern clinical practice. Recently, sonodynamic...
PURPOSE A 70-gene liquid biopsy (LB) panel (LBP-70) was implemented at our institution to identify genetic alterations in the plasma of patients with solid tumors. We report clinical utility LBP-70 a retrospective study 1,243 consecutively tested patients. MATERIALS AND METHODS Electronic medical records were reviewed for relevant clinicopathologic and radiologic information preanalytical variables, including circulating cell-free DNA yield. The assay evaluated on basis its ability major...
<div>AbstractPurpose:<p>Trastuzumab deruxtecan (T-DXd) is currently approved for treating metastatic breast cancer (MBC) that HER2 positive [immunohistochemistry (IHC) score of 3+ or <i>in situ</i> hybridization (ISH) positivity] HER2-low (IHC 1+ IHC 2+/ISH negative), as well HER2-positive gastric cancer, HER2-mutant lung and HER2-overexpressing solid tumors. Given the increasing utilization T-DXd, we sought to determine how status might change following T-DXd...
The use of RNA-based next-generation sequencing (NGS) assays to detect gene fusions for targeted therapy has rapidly become an essential component comprehensive molecular profiling. For cytology specimens, the cell block (CB) is most commonly used fusion testing; however, insufficient cellularity and/or suboptimal RNA quality are often limiting factors. In current study, authors evaluated factors affecting testing in and added value smears cases with a or inadequate CB.A 12-month...
The adult human breast comprises an intricate network of epithelial ducts and lobules that are embedded in connective adipose tissue. While previous studies have mainly focused on the system, many non-epithelial cell types remain understudied. Here, we constructed a comprehensive Human Breast Cell Atlas (HBCA) at single-cell spatial resolution. Our transcriptomics data profiled 535,941 cells from 62 women, 120,024 nuclei 20 identifying 11 major 53 states. These revealed abundant pericyte,...