A5027957798- Cervical Cancer and HPV Research
- AI in cancer detection
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Endometrial and Cervical Cancer Treatments
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Genital Health and Disease
- Cancer and Skin Lesions
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Advanced Biosensing Techniques and Applications
- MicroRNA in disease regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Educational Reforms and Innovations
The Ohio State University
2016-2025
The Ohio State University Wexner Medical Center
2016-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2020-2024
Augusta University Health
2023
Zhejiang University
2023
Emory University
2023
Hebei Medical University
2023
Fourth Hospital of Hebei Medical University
2023
University of Pittsburgh Medical Center
2011-2022
Yunnan University
2020-2022
Advances in computational algorithms and tools have made the prediction of cancer patient outcomes using pathology feasible. However, predicting clinical from pre-treatment histopathologic images remains a challenging task, limited by poor understanding tumor immune micro-environments. In this study, an automatic, accurate, comprehensive, interpretable, reproducible whole slide image (WSI) feature extraction pipeline known as, IMage-based Pathological REgistration Segmentation Statistics...
Introduction:The prevalence of cervical Human Papillomavirus (HPV) infection varies greatly worldwide and data regarding HPV genotypes in China are limited.Methods: testing results were retrospectively examined at KingMed Diagnostics, the largest independent pathology laboratory China, from January 2011 to June 2014.All was performed using 26 Genotyping Panel Tellgenplex TM xMAP™ DNA Test assay (TELLGEN, Shanghai, China).Overall prevalence, age-specific genotype distributions...
Hormone receptor-positive/HER2-negative (HR+/HER2-) breast cancer is associated with low levels of stromal tumor-infiltrating lymphocytes (sTIL) and PD-L1, demonstrates poor responses to checkpoint inhibitor therapy. Evaluating the effect standard chemotherapy on immune microenvironment may suggest new opportunities for immunotherapy-based approaches treating HR+/HER2- tumors.HR+/HER2- tumors were analyzed before after neoadjuvant chemotherapy. sTIL assessed histologically; CD8+ cells, CD68+...
Small cell neuroendocrine carcinoma (SCNEC) of the uterine cervix is a rare but extremely aggressive tumor. While high-risk human papillomavirus (HPV) involved at an early stage oncogenesis in many tumors, additional driving events have been postulated to facilitate progression SCNECs. Identification oncogenic drivers could guide targeted therapy this neoplasm. Clinicopathologic features 10 cervical SCNECs are reported. Analyses included immunohistochemical evaluation p16, p53,...
Cancer stem cells (CSC) play a central role in cancer metastasis and development of drug resistance. miRNA are important regulating CSC properties considered potential therapeutic targets. Here we report that miR-328-3p (miR-328) is significantly upregulated ovarian CSC. High expression miR-328 maintained by directly targeting DNA damage binding protein 2, which has been shown previously to inhibit Reduced activity ERK signaling CSC, mainly due low level reactive oxygen species, contributed...
Tissue biomarkers have been of increasing utility for scientific research, diagnosing disease, and treatment response prediction. There has a steady shift away from qualitative assessment toward providing more quantitative scores these biomarkers. The application image analysis thus become an indispensable tool in-depth tissue biomarker interrogation in contexts. This white paper reviews current technologies being employed analysis, their pitfalls, regulatory framework demands, guidelines...
Context.— Pathology practices have begun integrating digital pathology tools into their routine workflow. During 2020, the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), emerged as a pandemic, causing global health crisis that significantly affected world population in several areas, including medical practice, and was no exception. Objective.— To summarize our experience implementing for remote primary diagnosis, education, research during...
von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome caused by germline mutations of the<i>VHL</i> gene. Recent studies suggest that VHL protein (pVHL) component an E3 ubiquitin ligase, but the detailed biological function pVHL remains to be determined. To further elucidate functions pVHL, we searched pVHL-interacting proteins using yeast two-hybrid screening. A novel named VHL-interacting deubiquitinating enzyme 1 (VDU1) was identified as being able directly interact with <i>in...
MET is a receptor protein-tyrosine kinase (RPTK) for hepatocyte growth factor (HGF), which multifunctional cytokine controlling cell growth, morphogenesis, and motility. overexpression has been identified in variety of human cancers. Oncogenic missense mutations the tyrosine domain the<i>MET</i> gene have papillary renal carcinomas. In this study, RanBPM, also known as RanBP9, novel interacting protein through yeast two-hybrid screen. RanBPM contains conserved SPRY (repeats splA andRyR)...
The type 2 iodothyronine deiodinase (D2) is an integral membrane ER-resident selenoenzyme that activates the pro-hormone thyroxine (T4) and supplies most of 3,5,3′-triiodothyronine (T3) essential for brain development. D2 inactivated by selective conjugation to ubiquitin, a process accelerated T4 catalysis maintenance T3 homeostasis. A yeast two-hybrid screen human-brain library with as bait identified von Hippel–Lindau protein–interacting deubiquitinating enzyme-1 (VDU1). interaction VDU1...
Programmed cell death 1 (PD-1) and its ligand (PD-L1) are key physiologic suppressors of the cytotoxic immune reaction. However, to date, combination PD1/PD-L1 expression tumor-infiltrating lymphocytes (TILs) antigen-presenting cells has been only minimally reported in breast carcinoma, particular relation HER2-positive cases. The goal this study was evaluate both cellular tumoral reaction PD-L1/PD1 distribution cases, as well any associations with clinical outcome using conventional...
TRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast carcinomas. To further explore TRPS1's utility in carcinoma, we systematically evaluated expression on tissue microarrays from 160 estrogen receptor (ER)-positive/human epidermal growth factor 2 (HER2)-positive, 94 ER-/HER2+, 117 triple-negative carcinomas, 618 other primary carcinomas (cholangiocarcinoma, endometrial, colorectal, hepatocellular carcinomas), whole sections 64 HER2+, 76 triple-negative,...
Abstract Over 50% of all patients with cancer are treated radiotherapy. However, radiotherapy is often insufficient as a monotherapy and requires nontoxic radiosensitizer. Squalene epoxidase (SQLE) controls cholesterol biosynthesis by converting squalene to 2,3-oxidosqualene. Given that SQLE frequently overexpressed in human cancer, this study investigated the importance breast non–small cell lung (NSCLC), two cancers SQLE-positive IHC staining was observed 68% 56% NSCLC specimens versus 15%...
The integration of whole slide imaging (WSI) and artificial intelligence (AI) with digital cytology has been growing gradually. Therefore, there is a need to evaluate the current state cytology. This study aimed determine landscape via survey conducted as part American Society Cytopathology (ASC) Digital Cytology White Paper Task Force. A 43 questions pertaining practices experiences WSI AI in both surgical pathology was created. sent members ASC, International Academy (IAC), Papanicolaou...