A5001345657- Genetic factors in colorectal cancer
- Gut microbiota and health
- Genomics, phytochemicals, and oxidative stress
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Screening and Detection
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Helicobacter pylori-related gastroenterology studies
- AI in cancer detection
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- Renal Transplantation Outcomes and Treatments
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Diverticular Disease and Complications
- Genetic and Kidney Cyst Diseases
- Gastrointestinal disorders and treatments
- Mycobacterium research and diagnosis
- Inflammatory Bowel Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Nutrition, Genetics, and Disease
- Phytochemicals and Antioxidant Activities
- Diet and metabolism studies
The Ohio State University Wexner Medical Center
2016-2025
The Ohio State University
2013-2023
Community Hospital
2023
Asan Medical Center
2019
The University of Texas Health Science Center at San Antonio
2013-2019
University of British Columbia
2019
University of Massachusetts Chan Medical School
2019
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2015
Medical College of Wisconsin
2013
Cleveland Clinic
2008
We report the first description of sevelamer crystals (Renagel and Renvela, Genzyme; phosphate-lowering agents) in gastrointestinal tract. prospectively collected cases with novel, histologically identical from 4 major academic centers over a 1-year period studied pertinent clinicopathologic features. Sevelamer usage setting chronic kidney disease was demonstrated all (n=15 total cases, 7 patients). Sites involvement included esophagus (n=2), small bowel colon (n=11). The background mucosa...
We previously reported that oral administration of black raspberry powder decreased promoter methylation tumor suppressor genes in tumors from patients with colorectal cancer. The anthocyanins (ACs) raspberries are responsible, at least part, for their cancer-inhibitory effects. In the present study, we asked if ACs responsible demethylation effects observed cancers. Three days treatment 0.5, 5, and 25 μg/ml suppressed activity protein expression DNMT1 DNMT3B HCT116, Caco2 SW480 cells....
Context.— Pathology practices have begun integrating digital pathology tools into their routine workflow. During 2020, the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), emerged as a pandemic, causing global health crisis that significantly affected world population in several areas, including medical practice, and was no exception. Objective.— To summarize our experience implementing for remote primary diagnosis, education, research during...
Free fatty acid receptor 2 (FFAR2, also named GPR43), is activated by short-chain acids (SCFAs), such as butyrate, that are produced when gut bacteria ferment dietary fiber. FFAR2 has been suggested to regulate colonic inflammation, which a major risk factor for the development of colon cancer and linked epigenetic dysregulation in carcinogenesis. The current study assessed whether FFAR2, acting an regulator, protects against To mimic mild inflammation promotes human cancer, we treated mice...
The mechanism by which the virus associated with dengue fever can cause a fatal hepatitis is not well understood. purpose of this study was to examine 9 cases hemorrhagic fever-associated hepatitis, and correlate histologic findings viral detection cytokine response. changes were nonspecific included massive hepatic necrosis pauci-cellular acute hepatitis. Viral cDNA reverse transcriptase in situ polymerase chain reaction demonstrated that due infection on average >90% hepatocytes many...
To evaluate our experience of adding reflex BRAF mutation analysis following mismatch repair (MMR) protein staining in the test algorithm for Lynch syndrome (LS), most common inherited predisposition to colorectal cancer (CRC).Since January 1, 2009, V600E has been performed at institution all newly diagnosed CRCs with absent MLH1 and PMS2 proteins.Ninety (22%) 412 patients CRC had least 1 MMR (65 25 other stain(s) absent). was found 36 (55%) 65. Fifty-four (13%) required follow-up after...
Ulcerative colitis is frequently an intermediate step to colon cancer. The interleukin-10 knockout mouse a genetic model of this progression. We report that mice fed 5% black raspberries (BRB) had significantly less colonic ulceration as compared with consumed the control diet. Dysfunction Wnt signaling pathway key event in ulcerative colitis-associated carcinogenesis. Therefore, we investigated effects BRBs on and found BRB-fed exhibited lower level β-catenin nuclear translocation....
Ulcerative colitis (UC) is characterized by chronic inflammation of the colon. During inflammation, NF-κB increased in colonic epithelial cells and immune cells, leading to increases proinflammatory cytokines. These events then increase DNA methyltransferases (DNMTs), which silence a subset tumor suppressor genes promoter methylation. Negative regulators Wnt pathway are frequently methylated UC, dysregulation and, potentially, colorectal cancer. We determined if black raspberries (BRBs)...
We previously showed that black raspberries (BRBs) have beneficial effects in human colorectal cancer and a mouse model of (ApcMin/+). The current study investigated the role free fatty acid receptor 2 (FFAR2) colon carcinogenesis whether FFAR2 signaling pathway contributes to BRB-mediated chemoprevention mice. (also named GPR43) is member G-protein-coupled family expressed leukocytes colon. ApcMin/+ ApcMin/+-FFAR2-/- mice were given control diet or supplemented with 5% BRBs for 8 weeks....
Natural killer (NK) cells are an essential component of innate immunity against cancer development. Many studies have been conducted to evaluate immune-modulating effects using dietary compounds. Our laboratory has investigating the chemopreventive potential black raspberries (BRBs) and previously demonstrated their beneficial modulation genetic epigenetic biomarkers in patients with colorectal (CRC). The current study investigated on modulating NK cells. To avoid excessive inflammation...
OBJECTIVE Components of the adipose tissue (AT) extracellular matrix (ECM) are recently discovered contributors to obesity-related cardiometabolic disease. We identified increased adipocyte expression ECM-related clusterin (apolipoprotein J) in obese versus lean women by microarray. Our objective was determine 1) whether subcutaneous AT (SAd) and serum associated with insulin resistance (IR) known markers risk 2) how may contribute risk. RESEARCH DESIGN AND METHODS validated adipocytes from...
The gut microbiota—the community of microorganisms in the gut—has been implicated many physical and mental disorders addition to intestinal diseases. Diets are most studied promising factors for altering it. Indeed, certain dietary interventions that increase fiber intake rapidly change levels nutrients can modify composition microbiota, promoting richness diversity. Recent intriguing evidence from several human clinical trials suggested diversity patients' microbiotas at baseline influence...
ABSTRACT Hepatic malignancies in explanted livers are not uncommon; however, finding primary nonhepatic of any etiology is very rare. Given its rarity, we present a case low-grade B-cell lymphoma the liver explant patient with metabolic dysfunction–associated steatohepatitis cirrhosis after orthotopic transplantation. Preorthotopic transplantation workup was notable for periportal lymphadenopathy that negative malignancy per ultrasound-guided biopsy, so this surprising. This unexpected...
Mixed adeno-neuroendocrine carcinoma (MANEC) is a rare pathological diagnosis recently defined by the World Health Organization (WHO) in 2010. Prior to definition WHO, tumors with both adenocarcinoma and neuroendocrine components were given multiple designations making it difficult characterize disease. The aim of our study better MANEC understand its natural history influence patient care positively impact outcomes.The surveillance, epidemiology, end results program database was queried for...
Berries and their phytochemicals have well documented chemopreventive roles, but understanding ability to regulate cancer immunology is only beginning be explored. The literature, including human studies, suggests that berry components can modulate our immune system delay development. Moreover, wide spectrum of they might influence the functions multiple cells different aspects immunity. Cancer immune-therapies are showing promise for some types because boost T cells' recognize tumor - an...
Allogeneic transplantation of hematopoietic stem cells (HSC) in combination with T has a curative potential for malignancies through graft-versus-leukemia (GVL) effects, but is often compromised by the notorious side effect graft-versus-host disease (GVHD) resulting from alloreactivity donor cells. Here, we tested if temporary immunoisolation achieved conformally encapsulating within biocompatible and biodegradable porous film (∼450 nm thickness) chitosan alginate could attenuate GVHD...
Administration of black raspberries (BRBs) and their anthocyanin metabolites, including protocatechuic acid (PCA), has been demonstrated to exert chemopreventive effects against colorectal cancer through alteration innate immune cell trafficking, modulation metabolic inflammatory pathways, etc. Previous research shown that the gut microbiome is important in effectiveness chemoprevention cancer. This study aimed assess potency PCA versus BRB dietary administration for prevention using an...
HIV-seropositive individuals are at an increased risk for accelerated form of emphysema. The purpose this study was to determine the distribution HIV-1 RNA in lung tissues and correlate with histologic findings expression matrix metalloproteases (MMPs). Reverse transcriptase (RT) situ PCR analysis performed on 11 AIDS autopsy specimens which showed varying degrees emphysematous changes. In each lung, detected. areas histologically normal very rare HIV-1-infected cells were evident. contrast,...