Jiali Chen

ORCID: 0000-0002-7317-4146
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About
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Research Areas
  • Bone health and treatments
  • Bone and Joint Diseases
  • Protein Hydrolysis and Bioactive Peptides
  • Gut microbiota and health
  • Food composition and properties
  • Antibiotic Resistance in Bacteria
  • Pharmacological Effects of Natural Compounds
  • Osteoarthritis Treatment and Mechanisms
  • Nicotinic Acetylcholine Receptors Study
  • Aquaculture Nutrition and Growth
  • Metabolomics and Mass Spectrometry Studies
  • Wound Healing and Treatments
  • Bone Metabolism and Diseases
  • Food Quality and Safety Studies
  • Orthopedic Infections and Treatments
  • Phytochemicals and Antioxidant Activities
  • CRISPR and Genetic Engineering
  • RNA Interference and Gene Delivery
  • Bacterial biofilms and quorum sensing
  • COVID-19 and healthcare impacts
  • Genomics and Phylogenetic Studies
  • Probiotics and Fermented Foods
  • biodegradable polymer synthesis and properties
  • Phytochemistry and Biological Activities
  • Ginseng Biological Effects and Applications

Zhejiang Chinese Medical University
2021-2025

Jinan University
2020-2025

Sanya University
2023-2025

Hainan Provincial Academy of Agricultural Sciences
2023-2025

Hong Kong Baptist University
2014-2025

University of Macau
2021-2025

First Affiliated Hospital of Henan University of Science and Technology
2025

Harbin Medical University
2025

Second Affiliated Hospital of Harbin Medical University
2025

University of Guelph
2024

Constructing stable co-continuous morphology of commercial immiscible polymer blends remains an ongoing challenge in terms complex presynthetic routes, multiple parameter dependency, and intrinsic instability phase morphology. Herein, we demonstrate a full biodegradable blend, poly(lactic acid) (PLA) poly(butylene adipate-co-terephthalate), where hitherto inaccessible with asymmetric compositions (70/30) can be obtained the assistance interfacial stereocomplex crystallites (i-SCs) through...

10.1021/acs.macromol.0c02861 article EN Macromolecules 2021-03-03

Abstract BACKGROUND In order to utilize tilapia skin gelatin hydrolysate protein, which is normally discarded as industrial waste in the process of fish manufacture, we study vivo and vitro angiotensin‐I‐converting enzyme (ACE) inhibitory activity peptide Leu‐Ser‐Gly‐Tyr‐Gly‐Pro (LSGYGP). The aim was provide a pharmacological basis development minimal side effects ACE inhibitors by comparative analysis with captopril molecular docking. RESULTS This from protein‐rich wastes showed excellent...

10.1002/jsfa.10041 article EN Journal of the Science of Food and Agriculture 2019-09-16

<strong>Background:</strong> The incidence of hypertension has been increasing in the past decade. Little is known regarding relationship between and human development index (HDI). <strong>Objectives:</strong> objective to identify prevalence <strong>Methods:</strong> An ecological study was conducted. data from World Health Organization reports United Nations Development Programme for 182 countries, including HDI values, rates tobacco use, physical inactivity, alcohol salt intake....

10.5334/aogh.2591 article EN cc-by Annals of Global Health 2020-01-01

Bisphenol A (BPA) is an environmental endocrine disruptor. Recent studies have shown association between decreased spermatogenesis and gut microbiota alteration. However, the potential associations mechanisms of BPA exposure on spermatogenesis, hormone production, remain unknown. This study aims to investigate BPA-induced male reproductive toxicity link with dysbiosis. Male Sprague Dawley rats were exposed at different doses by oral gavage for thirty consecutive days. The extent testicular...

10.1016/j.ecoenv.2022.113623 article EN cc-by-nc-nd Ecotoxicology and Environmental Safety 2022-05-11

Microalgae are primary producers with multiple nutrients in aquatic environments and mostly have applications biological feed fuel industry. There few studies assessing the angiotensin-I-converting enzyme (ACE) inhibition potential of Isochrysis zhanjiangensis, other than its antioxidant potential. In this study, we evaluated a peptide from I. zhanjiangensis (PIZ, FEIHCC) vascular endothelial factors mechanism human umbilical vein cells (HUVEC). The results reveal that PIZ (IC50 = 61.38 μM)...

10.1021/acs.jafc.0c00925 article EN Journal of Agricultural and Food Chemistry 2020-03-26

A novel endoplasmic reticulum-targetable fluorescent probe, <bold>ER-CN</bold>, that can selectively sense reticulum H<sub>2</sub>S in living cells has been developed.

10.1039/c8ob02998a article EN Organic & Biomolecular Chemistry 2019-01-01

Cadmium is an environmental pollutant that has extensive deleterious effects on the reproductive system. However, mechanisms underlying of cadmium preimplantation embryos are unclear. Here, we used a mouse model to investigate maternal (32 mg/l) exposure in drinking water for 2 days early embryonic development, and studied associated with epigenetic modifications DNA damage induced by oxidative stress. We observed impaired embryo development inducing death, fragmentation, or developmental...

10.1016/j.ecoenv.2021.112306 article EN cc-by-nc-nd Ecotoxicology and Environmental Safety 2021-05-11

TGF-β signaling is crucial for modulating osteoarthritis (OA), and protein phosphatase magnesium–dependent 1A (PPM1A) has been reported as a of SMAD2 regulates signaling, while the role PPM1A in cartilage homeostasis OA development remains largely unexplored. In this study, we found increased expression chondrocytes confirmed interaction between phospho-SMAD2 (p-SMAD2). Importantly, our data show that KO substantially protected mice treated with destabilization medial meniscus (DMM) surgery...

10.1172/jci.insight.166688 article EN cc-by JCI Insight 2023-02-07

Donkey milk has a variety of physiological functions, including antibacterial and anti-inflammatory. whey proteins (DWPs), as the main functional component in donkey milk, its inhibitory effect on colitis is still unclear. In this study, potential mechanism DWPs dextran sulfate sodium (DSS)-induced were investigated. Firstly, bovine (BWPs) characterized using proteomics. Then, we administered BWPs to mice with via oral gavage. The results immunohistochemistry flow cytometry indicated that...

10.1016/j.fshw.2023.02.045 article EN cc-by-nc-nd Food Science and Human Wellness 2023-03-21

Background: Previous evidence has identified exposure to fine ambient particulate matter (PM2.5) as a leading risk factor for adverse health outcomes. However, date, only few studies have examined the potential association between long-term PM2.5 and bone homeostasis. Objective: We sought examine relationship explore its mechanism. Methods: This research included both observational experimental studies. First, based on human data from UK Biobank, linear regression was used associations...

10.1289/ehp11646 article EN public-domain Environmental Health Perspectives 2023-10-01

CT is increasingly detecting thyroid nodules. Prior studies indicated a potential role of CT-based radiomics models in characterizing nodules, although these lacked external validation.

10.2214/ajr.24.31077 article EN American Journal of Roentgenology 2024-05-01
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