A5103176573- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Tendon Structure and Treatment
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Gear and Bearing Dynamics Analysis
- TGF-β signaling in diseases
- Cancer, Lipids, and Metabolism
- Bone health and treatments
- Cancer Immunotherapy and Biomarkers
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Hops Chemistry and Applications
Zhejiang Chinese Medical University
2019-2024
TGF-β signaling is crucial for modulating osteoarthritis (OA), and protein phosphatase magnesium–dependent 1A (PPM1A) has been reported as a of SMAD2 regulates signaling, while the role PPM1A in cartilage homeostasis OA development remains largely unexplored. In this study, we found increased expression chondrocytes confirmed interaction between phospho-SMAD2 (p-SMAD2). Importantly, our data show that KO substantially protected mice treated with destabilization medial meniscus (DMM) surgery...
Abstract Although osteoarthritis (OA) in the hip joint is a common and debilitating degenerative disease, precise molecular mechanisms underlying its pathological process remains unclear. This study sets out to investigate whether β‐catenin plays critical role OA pathogenesis. Here, we showed overexpressed protein human cartilage tissues. Then, analyzed β‐cat(ex3) Col2ER mice, which gene was conditionally activated femoral head chondrocytes. At 2 months of age, mice already phenotype severe...
Abstract Emerging evidence suggests that microRNAs (miRNAs) may be pathologically involved in osteoarthritis (OA). Subchondral bone (SCB) sclerosis is accounted for the knee (KOA) development and progression. In this study, we aimed to screen miRNA biomarkers of KOA investigated whether these miRNAs regulate differentiation potential mesenchymal stem cells (MSCs) thus contributing SCB. We identified 48 blood samples patients ( n = 5) through microarray expression profiling detection. After...
Chondrogenesis and subsequent osteogenesis of mesenchymal stem cells (MSCs) angiogenesis at injured sites are crucial for bone fracture healing. Amygdalin, a cyanogenic glycoside compound derived from bitter apricot kernel, has been reported to inhibit IL-1 β -induced chondrocyte degeneration stimulate blood circulation, suggesting promising role amygdalin in In this study, tibial fractures C57BL/6 mice were treated with amygdalin. Fracture calluses then harvested subjected radiographic,...
Rheumatoid arthritis (RA) is a complex multifactorial autoimmune disease affected by genetics and environmental factors. The relationship between alcohol consumption RA remains controversial. This study aimed to assess the association risk using cross-sectional analysis Mendelian randomization (MR). We investigated through multivariate linear regression subgroup analyses. Data were obtained from National Health Nutrition Examination Survey (NHANES) 1999–2018 which involved 32,308...
Background: Cancer-associated fibroblasts (CAFs) play an important role in the tumorigenesis, immunosuppression and metastasis of colorectal cancer (CRC), can predict poor prognosis patients with CRC. The present study aimed to construct a CAFs-related prognostic signature for Methods: clinical information corresponding RNA data CRC were downloaded from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Estimation STromal Immune cells MAlignant Tumor tissues (ESTIMATES)...