A5101914988- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Natural Compounds in Disease Treatment
- Bioactive Compounds and Antitumor Agents
- Neuropeptides and Animal Physiology
- Cardiac, Anesthesia and Surgical Outcomes
- Heat shock proteins research
- Bioactive natural compounds
- Biochemical and Structural Characterization
- Curcumin's Biomedical Applications
- Epigenetics and DNA Methylation
- Epilepsy research and treatment
- Phagocytosis and Immune Regulation
- Analytical Methods in Pharmaceuticals
Wannan Medical College
2025
First Affiliated Hospital of Wannan Medical College
2025
Southern Medical University
2021-2024
Sichuan University
2017-2024
State Key Laboratory of Biotherapy
2024
Taipei Medical University-Shuang Ho Hospital
2023-2024
State Administration of Traditional Chinese Medicine of the People's Republic of China
2021-2024
Zhujiang Hospital
2021-2023
Harbin Medical University
2022-2023
Huazhong University of Science and Technology
2022
Abstract Doxorubicin (DOX) is widely used as a chemotherapeutic agent for both hematologic and solid tumors reasonable candidate glioma treatment. However, its effectiveness hindered by significant toxicity drug resistance. Moreover, the presence of blood–brain barrier (BBB) brings crucial challenge to therapy. In response, GSH‐responsive actively targeted nanoprodrug delivery system (cRGD/PSDOX‐Cur@NPs) are developed. this system, disulfide bond‐bridged DOX prodrug (PEG‐SS‐DOX) designed...
Abstract Metastasis in breast cancer usually lead to the majority of deaths on clinical patients. Accordingly, diagnosis metastasis at early stage is important improve prognosis. We observed that Dicer protein levels are significant decrease highly invasive cells and correlated with poor outcomes. Following, we aim clarify molecular regulatory mechanism this phenomenon provide a new therapeutic target. In study, obtained expression invasion without affect cell stability cells. Importantly,...
Using an Aβ-induced neurotoxicity blocking assay to direct fractionation, three new flavonoids, fleminginin (1), flemingichromone (2), and flemingichalcone (3), twenty known compounds were isolated from the active fractions of aerial parts Flemingia macrophylla. The structures 1 - 3 elucidated on basis spectroscopic data. When tested for neuroprotective activity, compound 2, osajin (4), 5,7,4′-trihydroxy-6,8-diprenylisoflavone (5), 5,7,4′-trihydroxy-6,3′-diprenylisoflavone (6), aureole (7)...
Chromatin immunoprecipitation followed by massively parallel DNA sequencing (ChIP-seq) or microarray hybridization (ChIP-chip) has been widely used to determine the genomic occupation of transcription factors (TFs). We have previously developed a probabilistic method, called TIP (Target Identification from Profiles), identify TF target genes using ChIP-seq/ChIP-chip data. To achieve high specificity, applies conservative method estimate significance genes, with trade-off being relatively low...
Altered DNA methylation, genetic alterations, and environmental factors are involved in tumorigenesis. As a tumor suppressor gene, abnormal EPHA5 methylation was found gastric cancer (GC) tissues linked to the initiation, progression prognosis of GC. In this study, level peripheral blood leukocytes (PBLs) detected explore its relationship with GC risk prognosis.A total 366 cases 374 controls were selected as subjects study collect their factors, status through methylation-sensitive...
Pancreatic cancer has one of the highest fatality rates and poorest prognosis among all types worldwide. Gemcitabine is a commonly used first-line therapeutic drug for pancreatic cancer; however, rapid development resistance to gemcitabine treatment been observed in numerous patients with cancer, this phenomenon limits survival benefit gemcitabine. Adenylosuccinate lyase (ADSL) crucial enzyme that serves dual functions de novo purine biosynthesis, it demonstrated be associated clinical...
Abstract Background: Drug resistance has become an obstacle to successful cancer chemotherapies, with therapeutic agents effectively traversing the blood-brain barrier (BBB) remaining a great challenge. Results: A microenvironmentresponsiveness and active targeting nanomicelle was constructed enhance penetration of drugs, leading improved effects. Dynamic light scattering demonstrated that prepared had uniform size. The cRGD modification renders capabilities traverse BBB for chemotherapy....
Identification of Transcription Factor Binding Sites (TFBS) from the upstream region genes remains a highly important and unsolved problem particularly in higher eukaryotic genomes. In this paper, we propose novel approach to identify transcription factor binding sites. This combines greedy method genetic algorithm (CGGA) search conserved segment given sequence set. A new which can efficiently local optimal result is proposed. order solve high complexity algorithm, also give an effective...
Identification of Transcription Factor Binding Sites (TFBS) from the upstream region genes remains a highly important and unsolved problem particularly in higher eukaryotic genomes. In this paper, we propose novel approach to identify transcription factor binding sites. This combines greedy method genetic algorithm (CGGA) search conserved segment given sequence set. A new which can efficiently local optimal result is proposed. order solve high complexity algorithm, also give an effective...