A5003339295- Plant biochemistry and biosynthesis
- Epigenetics and DNA Methylation
- Natural product bioactivities and synthesis
- Microbial Metabolic Engineering and Bioproduction
- 2D Materials and Applications
- Enzyme Catalysis and Immobilization
- Photosynthetic Processes and Mechanisms
- Neuroscience and Neuropharmacology Research
- Nanoparticle-Based Drug Delivery
- Microbial Natural Products and Biosynthesis
- Enzyme Production and Characterization
- Enzyme Structure and Function
- Nanoplatforms for cancer theranostics
- Single-cell and spatial transcriptomics
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Genomics and Phylogenetic Studies
- Advanced DC-DC Converters
- Organic Electronics and Photovoltaics
- Nanowire Synthesis and Applications
- Protein Structure and Dynamics
- Renal cell carcinoma treatment
Beijing Institute of Technology
2013-2025
National University of Singapore
2025
Chinese Academy of Sciences
2014-2024
Institute of Tibetan Plateau Research
2024
Bengbu Medical College
2024
University of Chinese Academy of Sciences
2021-2024
Tarim University
2024
Institute of High Energy Physics
2023
Tianjin Institute of Industrial Biotechnology
2013-2022
Northeast Normal University
2022
Protein stability and evolvability influence each other. Although protein dynamics play essential roles in various catalytically important properties, their high flexibility diversity makes it difficult to incorporate such properties into rational engineering. Therefore, how unlock the potential a user-friendly design process remains challenge. In this endeavor, we describe method for engineering an enantioselective alcohol dehydrogenase. It enables synthetically substrate acceptance...
Photothermal conversion ability (PCA) and cell internalization (CIA) are two key factors for determining the performance of photothermal agents. The previous studies mostly focus on improving PCA by exploring new nanomaterials. Herein, authors take hybrids graphene gold nanostar (GGN) as an example to investigate gradually enhanced phototherapy effect changing CIA therapy (PTT) agent simultaneously. Based GGN, GGN reduced protected bovine serum albumin (BSA) or BSA‐FA (folic acid) prepared,...
One-dimensional (1D) organic-inorganic hybrid perovskite nanowires (NWs) with well-defined structures possess superior optical and electrical properties for optoelectronic applications. However, most of the NWs are synthesized in air, which makes susceptible to water vapor, resulting large amounts grain boundaries or surface defects. Here, a template-assisted antisolvent crystallization (TAAC) method is designed fabricate CH3NH3PbBr3 arrays. It found that as-synthesized NW array has...
Introduction: Long non-coding RNAs (lncRNAs) are key regulators in multiple cancers. lncRNA, SNHG1, was shown to be associated with tumorigenesis. However, little is known about the role SNHG1 plays breast cancer. The aim of study and underlying mechanism regulation Methods: Quantitative real-time PCR used measure levels miR-382 ZEB1 cancer tissue or cells. proliferation, colony formation, migration invasion cells, under knockdown achieved by transfection SNHG1-specific siRNAs, were assessed...
Exciton emitters in two-dimensional monolayer transition-metal dichalcogenides (TMDs) provide a boulevard for the emerging optoelectronic field, ranging from miniaturized light-emitting diodes to quantum and optical communications. However, low efficiency limited light-matter interactions harmful substrate effects seriously hinders their applications. In this work, we achieve ∼438-fold exciton photoluminescence enhancement by constructing Fabry-Pérot cavity consisting of WS2 micron-scale...
Lateral junctions composed of quantum many-body materials are highly desirable for realizing physical phenomena and device concepts. However, controllable fabrication high-quality is challenging, which greatly hinders further exploration. Here, we successfully realize monolayer heterophase homojunctions metallic H-NbSe2 correlated insulating T-NbSe2 with atomically sharp boundaries via nanoscale polymorph engineering. By applying a scanning tunneling microscopy (STM) tip pulse, can be...
P-block metal monochalcogenides (MX) adopting black phosphorus (BP)-like structures are promising electrocatalysts due to their abundant exposed sites and tunable electronic structures. However, practical application is limited by structural instability arising from lone-pair electron-induced distortions, along with an inherent orbital symmetry mismatch the frontier orbitals of small molecules (e.g., CO2), reducing activation efficiency. Here, we report a noninvasive doping strategy overcome...
Acid-sensing ion channels (ASICs) are emerging as fundamental players in the regulation of neural plasticity and pathological conditions. Here we showed that lead (Pb2+), a well known neurotoxic metal ion, reversibly concentration-dependently inhibited ASIC currents acutely dissociated spinal dorsal horn hippocampal CA1 neurons rats. In vitro expression subunits combination demonstrated both ASIC1 -3 were sensitive to Pb2+. Mechanistically, Pb2+ reduced pH sensitivity ASICs independent...
Lipid-based nanoparticles as gene vectors have attracted considerable attention for their high transfection efficiency and low cytotoxicity. In our previous work, we synthesized gold nanoparticles/dimethyldioctadecylammonium bromide (DODAB)/dioleoylphosphatidylethanolamine (DOPE) (GDD) anionic lipid- pH-sensitive vectors. To further realize targeted transfection, a series of nanoparticles/DODAB/DOPE/DOPE-folic acid (DOPE-FA) with various ratios DOPE-FA were prepared termed GFn (for which...
Abstract Biodegradable organic field‐effect transistors (OFETs) have drawn tremendous attention for potential applications such as green electronic skins, degradable flexible displays, and novel implantable devices. However, it remains a huge challenge to simultaneously achieve high mobility, stable operation controllable biodegradation of OFETs, because most the widely used biodegradable insulating materials contain large amounts hydrophilic groups. Herein, is firstly proposed...
The ON-OFF direction selective ganglion cells (DSGCs) in the mammalian retina code image motion by responding much more strongly to movement one direction. They do so receiving inhibitory inputs selectively from a particular sector of processes overlapping starburst amacrine cells, type retinal interneuron. mechanisms establishment and regulation this connection are unknown. Here, we report that rat retina, morphology, physiology DSGCs circuitry for coding directions develop normally with...
This article presents a control strategy for the single-stage dual active bridge (DAB) ac-dc converters. To reduce conduction loss and achieve zero voltage switching (ZVS), global optimal working modes are reviewed. Based on modes, input current of DAB converter is analyzed sinusoidal voltage. The algorithm proposed to unit power factor with minimum stress ZVS. range meet wide load power. mode varied line-frequency angle power, which guarantees that works in modes. variation series...
Selective capture of microorganisms is an effective and rapid technique for microbe detection.
Terpenes and isoprenoids are the most diverse small organic molecules on Earth. Here, we obtained structures of sesquisabinene santalene synthases from Santalum album L. in presence or absence substrate, substrate-like, product-like for a total eight structures. All proteins crystallized an "open", noncatalytic conformation and, case FPP structure, three Mg2+ (MgABC) were bound active site region. We found that one these (MgB), involved pocket closure to catalytically conformation,...