A5078636925- Cervical Cancer and HPV Research
- AI in cancer detection
- Spectroscopy Techniques in Biomedical and Chemical Research
- Photoacoustic and Ultrasonic Imaging
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Molecular Biology Techniques and Applications
- Colorectal Cancer Screening and Detection
- Genital Health and Disease
- Spectroscopy and Chemometric Analyses
- Ovarian cancer diagnosis and treatment
- Lung Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Neuroendocrine Tumor Research Advances
- Urinary and Genital Oncology Studies
- Breast Lesions and Carcinomas
- Tissue Engineering and Regenerative Medicine
- Pleural and Pulmonary Diseases
- Cancer Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Radiology practices and education
Methodist Hospital
2012-2024
Methodist Hospital
2015-2024
Houston Methodist
2011-2024
Center for Genomic Science
2021
Cornell University
2011-2018
Weill Cornell Medicine
2018
Methodist Hospital
2011-2018
Columbia College - Missouri
2018
Dartmouth–Hitchcock Medical Center
2018
Harvard University
2018
Telecytology is the interpretation of cytology material at a distance using digital images. For more than decade, pioneering efforts to introduce telecytology into clinical practice have been reported. A Medline search for "telecytology" and "cytology" reveals voluminous literature, though much what has published date based on technologies that are rapidly becoming obsolete. The technological limitations previous techniques, including transmission static images dynamic streaming images,...
We compared the growth of human lung cancer cells in an ex vivo three-dimensional (3D) model and 2D culture to determine which better mimics patients. A549 were grown 3D for 15 days. measured size formation tumor nodules counted after also stained tissue/cells Ki-67, Caspase-3. matrix metalloproteinase (MMP) levels conditioned media blood plasma from patients with adenocarcinoma lung. Organized intact vascular space formed but not culture. Proliferation apoptosis greater After days, there...
The integration of whole slide imaging (WSI) and artificial intelligence (AI) with digital cytology has been growing gradually. Therefore, there is a need to evaluate the current state cytology. This study aimed determine landscape via survey conducted as part American Society Cytopathology (ASC) Digital Cytology White Paper Task Force. A 43 questions pertaining practices experiences WSI AI in both surgical pathology was created. sent members ASC, International Academy (IAC), Papanicolaou...
A custom built coherent anti-Stokes Raman scattering (CARS) microscope was used to image prostatic glands and nerve structures from 17 patients undergoing radical prostatectomy. Imaging of glandular showed distinctive cellular features that correlated histological stains. Segmentation cell nucleus performed establish a feature-based model separate normal cancer glands. In this study, we use single parameter, average neighbor distance based on CARS imaging, characterize cancerous structures....
We present a label-free, chemically-selective, quantitative imaging strategy to identify breast cancer and differentiate its subtypes using coherent anti-Stokes Raman scattering (CARS) microscopy.Human normal tissue, benign proliferative, as well in situ invasive carcinomas, were imaged ex vivo.Simply by visualizing cellular tissue features appearing on CARS images, cancerous lesions can be readily separated from proliferative lesion.To further distinguish subtypes, disease-related features,...
Context Whole slide imaging (WSI) produces a virtual image that can be transmitted electronically. This technology has clinical applications in situations which glass slides are not readily available. Objective To examine the results of validation study performed using draft version WSI guideline recently released by College American Pathologists. Design Ten iScan Coreo Au scanners (Ventana Medical Systems, Tucson, Arizona) were validated, 6 with one set 100 cases and 4 different cases, for...
Lung carcinoma is the leading cause of cancer-related death in United States, and non-small cell accounts for 85% all lung cancer cases.One major characteristic appearance desmoplasia deposition dense extracellular collagen around tumor.The desmoplastic response provides a radiologic target but may impair sampling during traditional image-guided needle biopsy difficult to differentiate from normal tissues using single label free imaging modality; translational purposes, label-free techniques...
Cervical screening with combined cytology and high-risk human papillomavirus (HR-HPV) detection has been approved for women 30 years or older. We investigated the clinical use of cotesting negative Papanicolaou tests. Follow-up cytology, HR-HPV test, biopsy findings were identified during an 18-month period. In 1 year, 2,719 cotests from 2,686 identified; 146 positive HR-HPV. Among testing, 120 had follow-up, including 70 repeated cotesting, 3 high-grade dysplasia (2.5% follow-up). 1,334...
We report the development and application of a knowledge-based coherent anti-Stokes Raman scattering (CARS) microscopy system for label-free imaging, pattern recognition, classification cells tissue structures differentiating lung cancer from non-neoplastic tissues identifying subtypes. A total 1014 CARS images were acquired 92 fresh frozen samples. The established pathological workup diagnostic cellular used as prior knowledge establishment using machine learning approach. This functions to...
Context The Papanicolaou (Pap) test has indisputably decreased cervical cancer mortality, as rates have declined by up to 80% in the United States since its implementation. However, Pap is considered less sensitive for detecting glandular lesions than those of squamous origin. Some studies even suggested an increasing incidence adenocarcinoma, which may be a consequence relatively reduced ability detect with screening techniques. Objective To evaluate detection rate techniques currently used...
The 2001 Bethesda System recommends reporting benign endometrial cells (BECs) in women aged >or=40 years and considers these at risk for pathology. current study examines the relative of hyperplasia or malignancy conferred by presence versus absence BECs Papanicolaou (Pap) tests years.Women represented 29,177 (46.2%) 63,202 Pap obtained over 1 year from a largely suburban screened population. Of these, 866 (3%) showed BECs. Over same period, 789 had histologic evaluations between 14 days 6...
Background: Automated screening of Papanicolaou tests (Pap tests) improves the productivity cytopathology laboratories.The ThinPrep ® Imaging System (TIS) has been widely adopted primarily for this reason use on Pap (TPPT).However, TIS may also influence interpretation tests, leading to changes in frequency various interpretive categories.The effect rates TPPT as atypical squamous cells undetermined significance (ASC-US) is concern because any shift ASC-US will alter sensitivity and...
Abstract High‐risk human papillomavirus (HR‐HPV) testing for colposcopy triage of low grade squamous intraepithelial lesion (LSIL) is not recommended because high positive rates in young women. It remains unclear whether HR‐HPV may be useful older We compiled data women aged ≥30 years with LSIL the period March 1, 2006 to February 28, 2008. Follow‐up cervical biopsy information was collected August 15, used Hybrid Capture II test performed on residual material from liquid‐based Pap tests. Of...
Robotic telepathology (RT) allows a remote pathologist to control and view glass slide over the internet. This technology has been demonstrated be effective on several platforms, but we present first report validation of RT using iScan Coreo Au whole imaging scanner.One intraoperative touch preparation from each 100 cases were examined twice (200 total cases) slides RT, with 3 week washout period between viewings, two different scanners at sites. included 75 consecutive neuropathology 25...