A5072859038- Cervical Cancer and HPV Research
- Genital Health and Disease
- Global Cancer Incidence and Screening
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- AI in cancer detection
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- Occupational and environmental lung diseases
- Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Tumors and Oncological Cases
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Fungal Infections and Studies
- Infectious Diseases and Mycology
- Hepatitis B Virus Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Reproductive tract infections research
Cornell University
2013-2024
Methodist Hospital
2014-2024
Houston Methodist
2009-2024
Methodist Hospital
2014-2023
Weill Cornell Medicine
2018-2022
College of American Pathologists
2000-2019
University of Central Florida
2019
Florida College
2019
George Washington University
2019
Cleveland Clinic
2019
Objective: Individuals are often infected with multiple genotypes of human papillomavirus (HPV) simultaneously, but the role these infections play in development cervical disease is not well established. This study aimed to determine association HPV high-risk lesions (hrCLs). Study Design: genotyping was performed on 798 SurePath specimens collected between December 1, 2009, and April 30, 2011. The cases were classified as hrCL (n = 90) or non-hrCL 708) based cytology diagnoses. infection...
Abstract Context.—The 2001 Bethesda System for the reporting of cervical cytology specimens and use new liquid-based human papillomavirus testing technologies have led to changes in practices. Objectives.—To analyze current laboratory practices using terminology compare results with previous survey data from 1996. Design.—Questionnaire mailed 1751 laboratories mid-2003. Participants.—Laboratories enrolled College American Pathologists Interlaboratory Comparison Program Cervicovaginal...
Thymic carcinoma (TCA) is a thymic epithelial neoplasm with obvious cytologic atypia. We studied 13 cases of TCA by light microscopy, immunohistochemistry, and electron microscopy correlated the findings clinical features. The patients' mean age was 54.2 years (range 30-74); male/female ratio 7/6. Twelve patients presented signs symptoms caused compression mediastinal organs; other patient asymptomatic. Paraneoplastic syndromes were never seen. At thoracotomy, 11 tumors invaded or adhered to...
Fine-needle aspiration (FNA) biopsy has proved to be a cost-effective technique, with low complication risks and high diagnostic value in distinguishing neoplastic versus nonneoplastic lesions many organs. This study was designed determine the reliability, areas of difficulty, limitations FNA diagnosis bone encountered university-affiliated tertiary care hospital.The cytology 450 biopsies lesions, performed on 427 patients between 1979 1996, were reviewed. The results correlated...
Abstract Context.—The Bethesda System for reporting cervical/vaginal cytologic diagnoses introduced terminology atypical squamous and glandular cells categories specimen adequacy. Objectives.—To analyze current laboratory practices compare trends to previous surveys. Design.—Questionnaire surveys were mailed 2000 laboratories in 1996 1997. Participants.—Laboratories enrolled the College of American Pathologists Interlaboratory Comparison Program Cervicovaginal Cytology. Main Outcome...
Context.—Digital whole slide imaging is the anticipated future of anatomic pathology, where sign-out glass slides will be replaced by scanned images. Whole has been successfully used in surgical but its usefulness and clinical application have limited cytology for several reasons, including lack availability z-axis depth focusing large file size. Recently, systems become available United States with technology. Objective.—To determine accuracy efficiency imaging, as compared traditional...
The histology of 69 human vertebral bodies from 23 individuals was studied by hematoxylin and eosin staining using a technique that allowed the creation complete, large histologic sections individual bodies. Particular attention directed toward documentation intraosseous nerves. were dissected free soft tissue, then sectioned diamond wafering saw into 3-mm sagittal segments. Sections decalcified whole-mounted in paraffin blocks before tissue sectioning very-large-format microtome. One...
Primary signet-ring-cell carcinoma of the prostate is extremely rare. We report eight patients with prostatic adenocarcinomas containing significant numbers signet-ring cells, one whom presented initially supraclavicular lymph node metastasis. Patient ages ranged from 50 to 80 years (mean, 67.5). None had received any form therapy before biopsy or surgery. All advanced disease (five stage C and three D). tumors were poorly differentiated adenocarcinomas, M.D. Anderson Hospital system grade...
Abstract Context.—Fine-needle aspiration (FNA) is recommended as an initial screening tool for the diagnosis of thyroid nodules. Approximately 10% FNA diagnoses are “suspicious neoplasm,” warranting surgical resection. Objectives.—To examine role a patient's age, sex, size nodule, and morphologic features possible predictors malignancy in patients with cytologic neoplasm.” Design.—Cytopathology slides reports 402 consecutive FNAs from 2000–2005 interpreted “suspicious” were reviewed. Of...
The current study compares data from our hospital system before and after the 2008 implementation of Bethesda System for Reporting Thyroid Cytology (BSRTC).To show effects BSRTC has had on reporting rates outcomes thyroid lesions.A search fine-needle aspiration biopsies (FNABs) was performed 2002-2005 (before BSRTC) 2009-2011 (after BSRTC). Diagnostic were reviewed cases with available follow-up.For 2002-2005, cytology reports 3302 FNABs reviewed, 309 (9.4%) classified as suspicious. For...
To compare results of immunohistochemical (IHC) assays for estrogen receptor (ER), progesterone (PR) and human epidermal growth factor 2 (HER2) performed on thrombin, formalin Cellient cell blocks to those tissue.Formalin, thrombin were prepared from cytologic samples obtained resection specimens 31 patients with invasive breast carcinoma. ER, PR, HER2 MIB-1 (Ki-67) IHC stains all three types compared the same patient's paraffin-embedded biopsy or resection. Cell tissue equivocal staining...
The importance of identifying papillary carcinoma or lymphoma amidst background Hashimoto's/lymphocytic thyroiditis (H/LT) is well documented. However, avoidance overdiagnosing neoplasms on thyroid fine-needle aspiration (FNA) with only H/LT has not been adequately addressed.This study aimed to identify cytomorphologic features leading within H/LT. Nine FNAs classified as suspicious positive for neoplasm subsequent thyroidectomy specimens having were identified. Cytologic these cases...
BACKGROUND In recent years, high‐risk human papillomavirus (hrHPV) testing for triaging atypical squamous cells of undetermined significance and cotesting with cytology have been implemented in clinical practice. However, data primary screening (HPV) alone are currently lacking. METHODS This study retrospectively reviewed the correlation cytology, histology, hrHPV through use a laboratory quality assurance database 130,648 Papanicolaou (Pap) tests interpreted at Houston BioReference...
Twenty-four male New Zealand rabbits underwent suture repair of a tenotomy the left achilles tendon. The were randomized into two groups 12 animals; in group (A), ankle was immobilized by pinning for 35 days, while (B), only 14 days followed active mobilization. Following sacrifice at postoperatively, retrieved tendons evaluated biomechanical testing and histologic examination. Approximately 50% stretching occurred first four days; average overall elongation 9.5±1.0 mm 12.7±1.5 (p = 0.102)...
Abstract Context.—Differentiating reactive effusion, malignant mesothelioma, and metastatic adenocarcinoma in body cavity fluids can be challenging. Interpreting immunohistochemical markers cell block preparations difficult because of nonspecific staining, focal or poor staining quality. We selected a panel conventional newer to assess their utility evaluating effusions. Objective.—To evaluate the efficacy 5 differential diagnosis mesothelial proliferation, fluids. Design.—A total 72...
Abstract Context.—Differentiating reactive effusion, malignant mesothelioma, and metastatic adenocarcinoma in body cavity fluids can be challenging. Interpreting immunohistochemical markers cell block preparations difficult because of nonspecific staining, focal or poor staining quality. We selected a panel conventional newer to assess their utility evaluating effusions. Objective.—To evaluate the efficacy 5 differential diagnosis mesothelial proliferation, fluids. Design.—A total 72...
Recognizing the difficulty in applying concept of critical values to anatomic pathology diagnoses, College American Pathologists and Association Directors Anatomic Surgical Pathology have chosen reevaluate diagnoses.
Twenty-seven fractured human vertebral bodies and 24 unfractured vertebrae from adjacent levels were studied postmortem using histologic high-resolution radiographic techniques. The findings compared with those in the of individuals without spinal fracture. Forty-six thoracolumbar spines obtained at autopsy. Standard radiographs made all specimens. Twelve 46 had a total 27 by plain criteria. Attention was focused on these as well that harvested level immediately to bodies. four no evidence...
Abstract Context.—Adenocarcinoma in situ of the cervix is a recently recognized interpretation Bethesda 2001 system. Although specific morphologic criteria have been published, recognizing this entity still difficult. Objective.—To compare pathologists' ability to correctly identify and categorize adenocarcinoma with their adenocarcinoma, high-grade squamous intraepithelial lesion, cell carcinoma. Design.—Pathologists' reviews 2002 College American Pathologists Interlaboratory Comparison...
To evaluate the efficacy of Ber-EP4 in distinguishing epithelial cells from mesothelial routine cytologic preparations.Paraffin-embedded cell blocks serous effusions 32 patients (11 metastatic adenocarcinomas, 16 reactive proliferations and 5 malignant mesotheliomas) were immunostained with Ber-EP4. For comparison, block preparations adenocarcinomas mesotheliomas also most commonly applied markers adenocarcinoma: carcinoembryonic antigen (CEA), B72.3 Leu-M1. In addition, cytocentrifuge 14 2...