A5023970220- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Tracheal and airway disorders
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Surgical Simulation and Training
- Cardiac, Anesthesia and Surgical Outcomes
- 3D Printing in Biomedical Research
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Dysphagia Assessment and Management
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Research Studies
- Airway Management and Intubation Techniques
- Advanced Radiotherapy Techniques
- Foreign Body Medical Cases
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
Methodist Hospital
2016-2025
Houston Methodist
2014-2024
Cornell University
2015-2024
Methodist Hospital
2012-2022
The University of Texas MD Anderson Cancer Center
2009-2018
Weill Cornell Medicine
2018
American College of Surgeons
2017
Allergan (United Kingdom)
2016
Creative Commons
2016
Methodist West Hospital
2016
Intratumoral collagen cross-links heighten stromal stiffness and stimulate tumor cell invasion, but it is unclear how cross-linking regulated in epithelial tumors. To address this question, we used Kras(LA1) mice, which develop lung adenocarcinomas from somatic activation of a Kras(G12D) allele. The tumors mice were highly fibrotic contained cancer-associated fibroblasts (CAF) that produced generated gels. In xenograft by injection wild-type with adenocarcinoma cells alone or combination...
Epithelial tumor metastasis is preceded by an accumulation of collagen cross-links that heighten stromal stiffness and stimulate the invasive properties cells. However, biochemical nature in cancer still unclear. Here, we postulated epithelial tumorigenesis accompanied changes type cross-links. Utilizing resected human lung tissues a p21CIP1/WAF1-deficient, K-rasG12D-expressing murine metastatic model, showed that, relative to normal tissues, stroma contains higher levels hydroxylysine...
Hypothesis: This study hypothesized that augmented reality (AR) technology has comparable accuracy and safety to conventional CT localization in guiding percutaneous transthoracic lung puncture (PTLP) localize small pulmonary nodules. Methods: was a prospective, non-inferiority randomized clinical trial. Patients were randomly assigned between 23 May 2023, 26 September 2023. with peripheral nodules (≤2 cm) recruited. either the CT-guided PTLP group or AR-guided group, 1:1 allocation ratio....
We compared the growth of human lung cancer cells in an ex vivo three-dimensional (3D) model and 2D culture to determine which better mimics patients. A549 were grown 3D for 15 days. measured size formation tumor nodules counted after also stained tissue/cells Ki-67, Caspase-3. matrix metalloproteinase (MMP) levels conditioned media blood plasma from patients with adenocarcinoma lung. Organized intact vascular space formed but not culture. Proliferation apoptosis greater After days, there...
Abstract Angiotensin II (Ang II)-mediated hypertension increases the risk for acute coronary syndrome, a consequence of atherosclerotic plaque rupture, which may be caused by matrix metalloproteinases (MMPs). Here, we show that human primary monocytes stimulated with tumor necrosis factor α (TNF-α) and granulocyte macrophage-colony stimulating (GM-CSF) release Ang II, is an integral component signal transduction pathway leads to MMP-1 production. An II-mediated increase in synthesis occurred...
Approximately 23,000 new gastric cancer cases and 12,000 associated deaths occur annually in the United States. Intestinal metaplasia epithelial dysplasia are precursor lesions to adenocarcinoma, but not readily detectable clinically, radiographically, or endoscopically. A noninvasive method of detection would require ability distinguish from adjacent normal mucosa. In search such markers, tissue microarrays were prepared for 133 patients resected adenocarcinoma. Tissue contained primary...
Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the clinical outcome of lung cancer patients have not been fully elucidated. Because Thy-1 (CD90) marks CAFs tumor cell invasion in a murine model KrasG12D-driven adenocarcinoma (KrasLA1), here we postulated human adenocarcinomas containing Thy-1+ worse prognosis. We first examined location within adenocarcinomas....
Aberrant expression of the oncogenic retrotransposon LINE-1 is a hallmark various cancer types, including non-small cell lung cancers (NSCLCs). Here, we present proof-of-principle evidence that analytes in extracellular vesicles (EVs) serve as tools for molecular diagnostics NSCLC, with status tumor cells and tissues mirroring mRNA ORF1p cargos EVs from culture conditioned media or human plasma. The levels plasma ostensibly healthy individuals were higher females than males. While profiles...
The extracellular matrix of epithelial tumors undergoes structural remodeling during periods uncontrolled growth, creating regional heterogeneity and torsional stress. How integrity is maintained in the face dynamic biophysical forces largely undefined. Here we investigated role fibulin-2, a glycoprotein that functions biomechanically as an inter-molecular clasp thereby facilitates supra-molecular assembly. Fibulin-2 was abundant human lung adenocarcinomas highly expressed tumor cell lines...