A5088715559- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Antimicrobial agents and applications
- Hepatitis B Virus Studies
- Advanced Chemical Sensor Technologies
- Animal Virus Infections Studies
- Mosquito-borne diseases and control
- Galectins and Cancer Biology
- Vector-Borne Animal Diseases
- Virology and Viral Diseases
- Nanocomposite Films for Food Packaging
- Advanced Causal Inference Techniques
- Statistical Methods in Clinical Trials
- Biomedical Research and Pathophysiology
- Multicomponent Synthesis of Heterocycles
- Species Distribution and Climate Change
- Escherichia coli research studies
- Cardiac and Coronary Surgery Techniques
- Herpesvirus Infections and Treatments
First Affiliated Hospital of Guangzhou Medical University
2020-2025
Guangzhou Medical University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
National Institute for Viral Disease Control and Prevention
2013-2025
Wenzhou Medical University
2023-2025
Wuhan Donghu University
2025
Wuhan University
2021-2025
Central South University
2021-2025
Third Xiangya Hospital
2025
Chinese Center For Disease Control and Prevention
2013-2024
The 2009 H1N1 influenza pandemic (pH1N1) led to record sales of neuraminidase (NA) inhibitors, which has contributed significantly the recent increase in oseltamivir-resistant viruses. Therefore, development and careful evaluation novel NA inhibitors is great interest. Recently, a highly potent inhibitor, laninamivir, been approved for use Japan. Laninamivir effective using single inhaled dose via its octanoate prodrug (CS-8958) demonstrated be against vitro. However, effectiveness...
Antigenic peptides recognized by virus-specific cytotoxic T lymphocytes (CTLs) are presented major histocompatibility complex (MHC; or human leukocyte antigen [HLA] in humans) molecules, and the peptide selection presentation strategy of host has been studied to guide our understanding cellular immunity vaccine development. Here, a severe acute respiratory syndrome coronavirus (SARS-CoV) nucleocapsid (N) protein-derived CTL epitope, N1 (QFKDNVILL), restricted HLA-A*2402 was identified series...
Abstract As one of the earliest identified susceptible animals for SARS-CoV-2, cats are also vulnerable hosts feline coronaviruses, ie enteric coronavirus (FECV). Here, to understand cross-presentation coronavirus-derived peptides by cat major histocompatibility complex molecule leucocyte antigen (FLA) class I, unpredictable natural peptide motifs presented FLA-K*00701 and FLA-E*00301 were through elution further confirmed structural determination 2 FLA I molecules. Based on these precise...
ABSTRACT The presentation of viral epitopes to cytotoxic T lymphocytes (CTLs) by swine leukocyte antigen class I (SLA I) is crucial for immunity. To illustrate the structural basis CTL epitope presentation, first SLA crystal structures, SLA-1*0401, complexed with peptides derived from either 2009 pandemic H1N1 (pH1N1) swine-origin influenza A virus (S-OIV NW9 ; NSDTVGWSW) or Ebola (Ebola AY9 ATAAATEAY) were determined in this study. overall peptide–SLA-1*0401 structures resemble, as...
Background: Propensity scores are useful for confounding adjustment in the commonly observed setting of many potential confounders, frequent exposure, and rare events. However, with few exposed outcomes to inform covariate selection candidate optimal approaches construct implement propensity-score–based remain unclear. Methods: In a cohort study on effect anticonvulsant drugs cardiovascular risk among adult patients from HealthCore Integrated Research Database, we compared performance...
Abstract The nectin and nectin-like molecule (Necl) family includes important cell adhesion molecules (CAMs) characterized by their Ig-like nature. Such CAMs regulate a broad spectrum of cell–cell interactions, including the interaction between NK cells cytotoxic T lymphocytes (CTLs) target cells. CAM members nectin-2 (CD112) Necl-5 (CD155) are believed to form homodimers (for nectin-2) or heterodimers in functions for adhesion, as well interact with immune costimulatory receptor DNAX...
Abstract The MHC has genetic associations with many diseases, often due to differences in presentation of antigenic peptides by polymorphic molecules T lymphocytes the immune system. In chickens, only a single classical class I molecule each haplotype is expressed well coevolution TAPs which means that resistance and susceptibility infectious pathogens are particularly easy observe. Previously, structures chicken BF2*2101 from B21 showed an unusually large peptide-binding groove accommodates...
Lack of a universal vaccine against all serotypes influenza A viruses and recent progress on T cell-related vaccines virus illuminate the important role human leukocyte antigen (HLA)-restricted cytotoxic lymphocytes (CTLs) in anti-influenza immunity. However, diverse HLA alleles among humans complicate virus-specific cellular immunity research, elucidation cross-HLA allele cell responses to specificity requires further detailed work. An ideal CTL epitope-based would cover broad spectrum...
Introduction This study aims to explore the relationship between trimethylamine N-oxide (TMAO), body composition, and protein-energy wasting (PEW) in patients undergoing maintenance hemodialysis (MHD).
Coronavirus disease 2019 (COVID-19) has exerted a profound influence on the global community over past few years. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to mutate, ongoing COVID-19 pandemic presents significant challenges public health. The serotype is defined as distinct variant within microbial species, characterized by specific immune reactions. It previously been used study various pathogens, such human papillomavirus and dengue virus. SARS-CoV-2...
ABSTRACT Background Airway management during the perioperative period is a vital component of care. However, there lack consensus on selection medications, timing administration, and airway complications. This aimed to promote more rational standardized application medications. Methods Clinical medical pharmaceutical experts were invited participate in this study using modified Delphi method. Participants completed two rounds online surveys, with second round based responses from first...
Novel strains of influenza A viruses ( IAV s) have emerged with high infectivity and/or pathogenicity in recent years, causing worldwide concern. T cells are correlated protection humans through cross‐reactive immunity against heterosubtypes . However, the different hierarchical roles ‐derived epitopes distinct levels polymorphism ‐cell responses remain elusive. In this study, immunodominant scattered throughout entire proteome 2009 pandemic H1N1 virus and seasonal s were synthesized divided...
ABSTRACT The presentation of viral peptide epitopes to host cytotoxic T lymphocytes (CTLs) is crucial for adaptive cellular immunity clear the virus infection, especially some chronic infections. Indeed, hosts have developed effective strategies achieve this goal. ideal scenario would be that stimulate a broad spectrum CTL responses with diversified T-cell receptor (TCR) usage (the TCR repertoire). It believed repertoire requires “featured” presented by major histocompatibility complex...
Structurally, Group 1 LILR (Leukocyte Immunoglobulin (Ig)-Like Receptor, also known as Ig-like transcripts, ILT; Leukocyte receptor, LIR; and CD85) members are very similar in terms of the HLAIs (human leukocyte antigen class I molecules) binding region were hypothesized that they all bind to HLAIs. As one LILRs, LILRA3 is only secretory may greatly control inhibitory immune response induced by LILRB1, LILRB2, other HLA-binding molecules like LILRA1. Nevertheless, little was about In this...
Abstract Chronic airway remodeling is a serious consequence of asthma, which caused by complex but largely unknown mechanisms. Despite versatile functions, the role Lyn in chronic remains undefined. Using Lyn−/− mice, we show that continual exposure (for 8 wk) house dust mite extracts induced severe phenotype remodeling, including exacerbated mucus production, collagen deposition, dysregulated cytokine secretion, and elevated inflammation. Strikingly, significant increase TGF-β3 rather than...
Abstract MHC class I (MHC I)–restricted virus-specific CTLs are implicated as critical components in the control of this naturally occurring lentivirus and protective immune response to successfully applied attenuated equine infectious anemia virus vaccine horse. Nevertheless, structural basis for how presents epitope peptides remains unknown. In study, we investigated binding several virus–derived by ability refold recombinant molecules thermal stability, then determining x-ray structure...
Although antibacterial peptides with excellent properties emerge endlessly, the alternating structures have not attracted much attention. In this work, three amino acid copolymers (Orn-Ser, Orn-Gly, and Orn-Val) similar molecular weights but different hydrophilicity were constructed for study of through solid-phase peptide synthesis (SPPS) method. We found that these showed biocompatibility broad spectrum activity. Nevertheless, they slightly due to differences in cationic density, instance,...
The emerging viruses within the genus Henipavirus in family Paramyxoviridae pose a great threat to public biosafety. To develop quadruple real-time fluorescence-based quantitative reverse transcription polymerase chain reaction (qRT-PCR) assay is pivotal for early warning of potential zoonotic infectious diseases. Specific primers and probes were designed relatively conserved regions based on whole genome sequences Langya virus (LayV), Mojiang (MojV), Nipah (NiV), Cedar (CedV), followed by...