A5027086950- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Gut microbiota and health
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Intraperitoneal and Appendiceal Malignancies
- Advanced Nanomaterials in Catalysis
- Appendicitis Diagnosis and Management
- Nanoplatforms for cancer theranostics
- Probiotics and Fermented Foods
- Cancer-related molecular mechanisms research
- Protein Tyrosine Phosphatases
- Helicobacter pylori-related gastroenterology studies
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Xi'an Jiaotong University
2014-2025
National Institute for Viral Disease Control and Prevention
2025
Wenzhou Medical University
2025
University of North Carolina at Chapel Hill
2023
First Hospital of Xi'an
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2006
A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a drug-free, biodegradable nanomedicine acts against IBD by scavenging cell-free DNA (cfDNA) and reactive oxygen species (ROS). Polyethylenimine (PEI) was conjugated to antioxidative diselenide-bridged mesoporous organosilica nanoparticles (MONs) formulate (MON-PEI) exhibited high cfDNA binding affinity...
Abstract The microbiome in a specific human organ has been well-studied, but few reports have investigated the multi-organ as whole. Here, we aim to analyse intra-individual inter-organ and intra-organ deceased humans. We collected 1608 samples from 53 sites of 7 surface organs (oral cavity, esophagus, stomach, small intestine, appendix, large intestine skin; n = 33 subjects) performed profiling, including 16S full-length sequencing. Microbial diversity varied dramatically among organs, core...
ABSTRACT To improve the long‐term therapeutic efficacy of colorectal cancer, we propose a synergistic treatment strategy involving dual‐pathway, multistep induction hyperimmunity combined with photothermal‐chemotherapy. implement this strategy, infinite coordination polymer nanoparticles (SN38‐Mn(II)‐EGCG ICP NPs) were prepared by coordinating SN38, EGCG, and Mn 2+ . These then coated polydopamine (PDA) grafted folate‐PEG‐thiol (FA‐PEG‐SH) onto their surfaces, producing tumor‐targeting...
Objective: A large-scale multicenter retrospective cohort study was conducted to compare the short- and long-term outcomes of robotic gastrectomy (RG) laparoscopic (LG) for gastric cancer. Summary Background Data: RG is being increasingly used worldwide, but data from studies on oncologic versus LG are limited. The potential benefits compared with cancer remain controversial. Methods: Data eligible patients who underwent or 11 experienced surgeons 7 centers in China between March 2010...
Abstract Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study role appendectomy colorectal cancer (CRC) risk through causing microbial dysbiosis. Population-based longitudinal (cohort 1, n = 129,155) showed a 73.0% increase CRC among cases throughout 20 years follow-up (Adjusted sub-distribution hazard ratio (SHR) 1.73, 95% CI 1.49–2.01, P < 0.001). Shotgun metagenomic sequencing was performed on fecal samples from cohort 2 ( 314). Gut dysbiosis subjects...
Objective: To compare the short- and long-term outcomes between robotic gastrectomy (RG) laparoscopic (LG) for gastric cancer. Summary Background Data: The clinical of RG over LG have not yet been effectively demonstrated. Methods: This retrospective cohort study included 3,599 patients with cancer who underwent radical at eight high-volume hospitals in China from August 2016 to June 2019. Propensity score matching (PSM) was performed received LG. primary endpoint 3-year disease-free...
Abstract Inspired by the timely emergence of silkworm pupae from their cocoons, chrysalis‐like probiotic composites (SCPCs) are developed for comprehensive therapy inflammatory bowel disease (IBD), in which probiotics enveloped as “pupa” a sequential layering silk sericin (SS), tannic acid (TA), and polydopamine, akin to protective “cocoon”. Compared unwrapped probiotics, these not only demonstrate exceptional resistance harsh gastrointestinal environment exhibit over 200 times greater...
Oral supplemented nutraceuticals derived from food sources are surmised to improve the human health through interaction with gastrointestinal bacteria. However, lack of fundamental quality control and authoritative consensus (e.g. formulation, route administration, dose dosage regimen) these non-medical yet bioactive compounds one main practical issues resulting in inconsistent individual responsiveness confounded clinical outcomes consuming nutraceuticals. Herein, we studied effects widely...
Nicotinamide adenine dinucleotide (NADH) is central to metabolism and implicated in various diseases. Herein, nanohybrids of gold nanostars metal–organic frameworks are devised demonstrated as a dual-mode NADH sensor, for which colorimetric detection enabled by its peroxidase-like nanozyme property Raman realized surface-enhanced scattering with the limit low 28 pM. More importantly, this probe enables real-time SERS monitoring living cells, providing unique tool investigate dynamic cellular...
Abstract Background Lateral lymph node dissection (LLND) represents a technically challenging procedure. This study aimed to evaluate the perioperative, genitourinary functional and mid-term oncological outcomes of laparoscopic lateral (LLLND) robotic (RLLND) for advanced lower rectal cancer (ALRC). Methods Between January 2015 April 2021, consecutive patients who underwent RLLND LLLND at two high-volume centres were enrolled. The perioperative outcomes, function recovery compared. A...
Abstract Treatment guidelines for colorectal cancer (CRC) in elderly patients remain unclear. This study aimed to investigate whether (≥ 70 years) with CRC benefit from surgery and adjuvant therapy. A total of 90,347 eligible older than years were collected the Surveillance, Epidemiology, End Results (SEER) database divided into a group no-surgery group. After being matched by propensity score matching at 1:1 ratio, 23,930 included our analysis. The Kaplan‒Meier method log-rank test applied...
Aim: To investigate the role of exosomal miRNAs on gastric cancer (GC) metastasis. Materials & methods: miRNA expression profiles exosomes with distinct invasion potentials were analyzed using microarray and validated by quantitative real-time PCR. In vitro in vivo experiments assessed miR-196a-1 GC's Results: High level was significantly associated poor survival GC. Exosomes that contained secreted from high-invasive GC cells. Ectopic promoted low-invasive cells targeting SFRP1. Conclusion:...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
Acute liver failure (ALF) is a complicated clinical syndrome associated with high mortality, transplantation as the only treatment option. Treatment of mesenchymal stem cells has shown potential therapeutic option for acute failure. However, lack random trials and large non-human primate studies makes it necessary to assess efficacy safety in clinic.We treated monkeys peripheral delivery human umbilical MSCs (hUC-MSCs) investigated role hUC-MSCs modulating progress failure.The use early...
Metal/silica nanoparticles (NPs) have long been used as antibacterial substitutes; however, fabrication of a degradable carrier for achieving sustained release profile, high bactericidal efficacy, and good biocompatibility is still challenge. Herein, we fabricated nanosilver-decorated biodegradable mesoporous organosilica (MONs) using biocompatible natural polyphenol, tannic acid (TA), not only nonsurfactant template to form MONs but also reducible agent generate nanosilvers. Such...
Rationale: Protein kinases are critical therapeutic targets for curing hepatocellular carcinoma (HCC). As a serine/threonine kinase, the potential roles of kinase 39 (STK39) in HCC remain to be explored. Methods: The expression STK39 was examined by RT-qPCR, western blotting and immunohistochemistry. Cell proliferation apoptosis were detected CCK8 TUNEL kit. migration invasion assays performed using transwell system with or without Matrigel. RNA-seq, mass spectrometry luciferase reporter...
Abstract Background Many patients experience anorectal dysfunction after rectal surgery, which is known as low anterior resection syndrome (LARS). Robotic systems have many technical advantages that may be suitable for functional preservation resection. Thus, the study aimed to explore whether robotic surgery can reduce incidence and severity of LARS. Methods Patients undergoing minimally invasive sphincter-sparing cancer were enrolled between January 2015 December 2020. The divided into or...