A5075524458- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Berberine and alkaloids research
- Extracellular vesicles in disease
- Diatoms and Algae Research
- Mesoporous Materials and Catalysis
- MicroRNA in disease regulation
- Alkaloids: synthesis and pharmacology
- Cancer Genomics and Diagnostics
- Biosensors and Analytical Detection
- Analytical chemistry methods development
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Inflammatory Bowel Disease
- Graphene and Nanomaterials Applications
- Phytochemical Studies and Bioactivities
- Photodynamic Therapy Research Studies
- Carbon and Quantum Dots Applications
- Gout, Hyperuricemia, Uric Acid
- Porphyrin and Phthalocyanine Chemistry
- Drug-Induced Hepatotoxicity and Protection
- Nanoparticles: synthesis and applications
- Nanocluster Synthesis and Applications
- Liver Diseases and Immunity
South China University of Technology
2019-2024
Jilin University
2018-2021
Jilin Medical University
2018-2019
College of Medical Sciences
2018-2019
Nanomed (Brazil)
2018
A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a drug-free, biodegradable nanomedicine acts against IBD by scavenging cell-free DNA (cfDNA) and reactive oxygen species (ROS). Polyethylenimine (PEI) was conjugated to antioxidative diselenide-bridged mesoporous organosilica nanoparticles (MONs) formulate (MON-PEI) exhibited high cfDNA binding affinity...
Combining radiotherapy with immune checkpoint blockade therapy offers a promising approach to treat glioblastoma multiforme (GBM), yet challenges such as limited effectiveness and immune-related adverse events (irAEs) persist. These issues are largely due the failure in targeting immunomodulators directly tumor microenvironment. To address this, biomimetic nanoplatform that combines genetically modified mesenchymal stem cell (MSC) membrane bioactive nanoparticle core for chemokine-directed...
Cationic nanoparticles ameliorate severe sepsis progression through scavenging cell-free DNA.
Chronic diabetic wound healing remains a challenge due to the existence of excessive danger molecules and bacteria in inflammatory microenvironment. There is an urgent need for advanced dressings that target both inflammation infection. Here, bioactive hydrogel without loading any anti-inflammatory ingredients rationally designed achieve "Pull–Push" approach efficient safe bacteria-infected by integrating molecule scavenging (Pull) with antibiotic delivery (Push) The cationic hydrogel,...
Abstract Exploration of medicines for efficient and safe management metabolic‐associated fatty liver disease (MAFLD) remains a challenge. Obeticholic acid (OCA), selective farnesoid X receptor agonist, has been reported to ameliorate injury inflammation in various diseases. However, its clinical application is mainly limited by poor solubility, low bioavailability, potential side effects. Herein hepatic‐targeted nanodrugs composed OCA cholesterol‐lowering atorvastatin (AHT) with an ideal...
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury and acute failure, while the detection, prognosis prediction, therapy for APAP-induced (AILI) remain improved. Here, it determined that temporal pattern circulating cell-free DNA (cfDNA) strongly associated with damage inflammation parameters in AILI. CfDNA comparable to alanine aminotransferase (ALT) predicting mortality outperformed ALT when combined The depletion cfDNA or neutrophils alleviates damage, addition...
Despite the vital role miRNA-27a plays in driving development and progress of liver cancer, miRNA-based inhibition therapy is hampered due to its undesired degradation off-target effects. Herein, a multifunctional nanoparticle for noninvasive tracking targeted delivery anti-miR-27a oligonucleotides against cancer was constructed. Methods: Dual-fluorescent conjugates (QD-HA-PEI) were first fabricated through crosslinking hyaluronic acid (HA), polyethyleneimine (PEI) near-infrared (NIR)...
Metal/silica nanoparticles (NPs) have long been used as antibacterial substitutes; however, fabrication of a degradable carrier for achieving sustained release profile, high bactericidal efficacy, and good biocompatibility is still challenge. Herein, we fabricated nanosilver-decorated biodegradable mesoporous organosilica (MONs) using biocompatible natural polyphenol, tannic acid (TA), not only nonsurfactant template to form MONs but also reducible agent generate nanosilvers. Such...
Fluorescent berberine-based carbon dots (Ber-CDs) were prepared through a facile synthesis strategy. Ber-CDs exhibited excellent optical properties for bioimaging and retained the biofunctions of berberine, enabled selective safe anti-tumor performance, demonstrating their promising application potential in cancer theranostics.
There is a growing belief that depression was positively associated with the progression of liver cancer. However, driving molecular events behind in cancer are poorly understood and need to be elucidated. Since hyperactivity hypothalamic–pituitary–adrenal axis during leads excessive release glucocorticoids (GCs), which suppress activity natural killer (NK) cells, we hypothesized high levels GCs may inhibit function tumor-infiltrating NK cells progress Using chronic unpredictable mild...
Chlorhexidine (CHX) is a widely used antiseptic in various infection control practices. In this work, we have developed biodegradable mesoporous organosilica nanoparticles (MONs) through one-pot synthesis by employing CHX as bifunctional agent that not any acts cationic template to form the structure of mesopores but also serves broad-spectrum antiseptic. The resulting CHX@MONs exhibit relatively high content and glutathione (GSH)-responsive release via matrix-degradation-controlled...
Hepatocellular carcinoma (HCC) is one of the most malignant cancers around world. HCC less sensitive to conventional cytotoxic agents and easily develops into systemic metastases. However, molecular mechanisms metastasis are poorly understood need elucidation.Transwell system chemotherapy-challenged unchallenged HepG2 cells was established. Adhesion assay scratch-wound were utilized analyze adhesion migration cells. iPLA2 LOX-5 expression analyzed by Western blot. LTB4 level...
The trace amount of cell-free DNA (cfDNA) in urine provides a promising diagnosis urological disease, but its clinical applications are restricted by complicated operations for enrichment and detection. Herein, portable visual smartphone-based colorimetric platform is created cfDNA quantification quick, low-cost, instrument-free manners. enriched the zinc ions-dipicolylamino complexes on glass slides labeled PicoGreen (PG) to form DNA-PG with photocatalysis generation visible output signal....