A5049958452- Cancer-related molecular mechanisms research
- Inflammatory Bowel Disease
- Curcumin's Biomedical Applications
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Multiple Myeloma Research and Treatments
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Aortic aneurysm repair treatments
- Vascular anomalies and interventions
- Immune cells in cancer
- Selenium in Biological Systems
- Medical and Biological Ozone Research
- Extracellular vesicles in disease
- Pregnancy and Medication Impact
- Global Cancer Incidence and Screening
- Vascular Procedures and Complications
- Cancer Mechanisms and Therapy
Tianjin First Center Hospital
2025
Tianjin Medical University
2025
First Affiliated Hospital of Xi'an Jiaotong University
2021-2024
A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a drug-free, biodegradable nanomedicine acts against IBD by scavenging cell-free DNA (cfDNA) and reactive oxygen species (ROS). Polyethylenimine (PEI) was conjugated to antioxidative diselenide-bridged mesoporous organosilica nanoparticles (MONs) formulate (MON-PEI) exhibited high cfDNA binding affinity...
Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammation of the gastrointestinal tract. Oxidative stress plays a pivotal role in pathogenesis IBD. Selenium-containing amino acids reportedly have anti-oxidative and anti-inflammatory properties, but it remains unknown if selenium-containing can be used to treat This study aimed investigate effects two - selenocysteine selenocystine on oxidative mouse model dextran sulfate sodium (DSS)-induced IBD.C57BL/6 mice were...
Persistent sciatic artery (PSA) is a rare anatomic variant disease with an incidence of approximately 0.025%-0.05% it considered to be axial congenital vascular malformation, which may related the failure degeneration and iliofemoral dysplasia. Some patients asymptomatic, while others experience chronic pain, thrombosis, aneurysm formation. We report case 63-year-old female patient superficial femoralartery (SFA)-common femoral vein (CFV) arteriovenous fistula found on ultrasound lower...
Breast cancer (BC) is the most prevalent in women globally. The tumor microenvironment (TME), comprising epithelial cells and stromal elements, vital for breast development. N6-methyladenosine (m6A) modification plays a key role RNA metabolism, influencing its various aspects such as stability translation. There notable link between m6A methylation immune TME, although this relationship complex not fully deciphered. In research, BC expression clinicopathological data from TCGA were...
Multiple myeloma (MM), an incurable plasma cell malignancy. The significance of the relationship between natural killer (NK) cell-related genes and clinical factors in MM remains unclear.
Breast cancer (BC) is the most common among women globally and poses leading health threat to worldwide, with persistently high incidence rates. Mitophagy a selective autophagy process that specifically targets mitochondria within cell, maintaining cellular energy balance metabolic by identifying degrading damaged mitochondria. Although there an understanding of relationship between mitophagy cancer, specific mechanisms remain unclear due complexity diversity mitophagy, suggesting it could...
The management of inflammatory bowel disease (IBD) continues to pose significant challenges due the absence curative therapies and a high rate recurrence. Therefore, it is imperative explore novel approaches enhance efficacy IBD therapy. Herein, bioactive nanoparticulate s tailored designed achieve "Pull-Push" approach for efficient safe treatment by integrating reactive oxygen species (ROS) scavenging (Pull) with anti-inflammatory agent delivery (Push) in microenvironment. multifunctional...
ABSTRACT Background Immunotherapy has shown promise for bladder cancer (BC) treatment but is effective only in a subset of patients. Understanding the tumor microenvironment (TME) and its regulators, such as expression N6‐methyladenosine (m6A) may improve therapeutic outcomes. This study focuses on role IGF2BP2, an m6A reader, modulating BC TME. Methods Transcriptomic single‐cell RNA‐seq data from public databases were analyzed to identify subgroups investigate IGF2BP2's Clustering PCA...
Abstract Whether patients with medullary breast carcinoma (MBC) receive chemotherapy is controversial. Therefore, the aim of our study was to screen out MBC who benefit from chemotherapy. We enrolled 618 consecutive The Surveillance, Epidemiology, and End Results (SEER) database (2010–2018). Cox regression analysis used identify independent prognostic factors. Next, a nomogram constructed evaluated using calibration plots area under curve (AUC) receiver operating characteristic (ROC) curves....