A5101587354- Advanced Cellulose Research Studies
- Nanocomposite Films for Food Packaging
- Acute Kidney Injury Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Gut microbiota and health
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Organ and Tissue Transplantation Research
- Electrolyte and hormonal disorders
- Transplantation: Methods and Outcomes
- Tissue Engineering and Regenerative Medicine
- Chronic Kidney Disease and Diabetes
- RNA modifications and cancer
- Immune cells in cancer
- Appendicitis Diagnosis and Management
- Orthopedic Surgery and Rehabilitation
- Intraperitoneal and Appendiceal Malignancies
- Neurogenesis and neuroplasticity mechanisms
- Ovarian cancer diagnosis and treatment
- Xenotransplantation and immune response
- Neuroinflammation and Neurodegeneration Mechanisms
- Environmental Chemistry and Analysis
- Foot and Ankle Surgery
- Medical and Biological Ozone Research
- Sports injuries and prevention
University of Science and Technology of China
2019-2025
Central South University
2022-2024
Fudan University
2022-2024
Second Xiangya Hospital of Central South University
2022-2024
Anhui Medical University
2024
Juntendo University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2017-2023
Xi'an Jiaotong University
2018-2023
First Affiliated Hospital of Hebei Medical University
2016-2023
Hebei Medical University
2016-2023
Abstract Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study role appendectomy colorectal cancer (CRC) risk through causing microbial dysbiosis. Population-based longitudinal (cohort 1, n = 129,155) showed a 73.0% increase CRC among cases throughout 20 years follow-up (Adjusted sub-distribution hazard ratio (SHR) 1.73, 95% CI 1.49–2.01, P < 0.001). Shotgun metagenomic sequencing was performed on fecal samples from cohort 2 ( 314). Gut dysbiosis subjects...
Abstract The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune that affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell survival, counteracting inflammation. Its role in renal injury, particular, unilateral ureteral obstruction (UUO) or ischemia-reperfusion injury (IRI)-induced remains unclear. In our study, WT Trem2 −/− mice were employed to evaluate the of TREM2 macrophage infiltration tissue after UUO. Bone marrow-derived macrophages...
Ulcerative colitis (UC) is an inflammation-related disease involved in uncontrolled inflammation and oxidative stress characterized by high recurrence relapse risk. As a rising star gas medicine, methane owns the properties of anti-inflammation, antioxidation, antiapoptosis. Based on possible mechanism, we aimed to investigate effect UC. Methane-rich saline (MRS) was introduced here, UC induced acetic acid. All C57BL/6 mice were allocated into groups as follows: control group, model treated...
Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammation of the gastrointestinal tract. Oxidative stress plays a pivotal role in pathogenesis IBD. Selenium-containing amino acids reportedly have anti-oxidative and anti-inflammatory properties, but it remains unknown if selenium-containing can be used to treat This study aimed investigate effects two - selenocysteine selenocystine on oxidative mouse model dextran sulfate sodium (DSS)-induced IBD.C57BL/6 mice were...
This study examined the effects of RNAi-mediated TUSC3 silencing on radiation-induced autophagy and radiation sensitivity human lung adenocarcinoma cell line A549 under hypoxic condition. Different CoCl2 concentrations were used to treat cells establish a CoCl2-induced model cells. MTT clone formation assays determine different growth proliferation treated by doses X-ray irradiation. The siRNA-expressing vector was transfected liposomes for TUSC3. Flow cytometry measure cycle changes...
Oral supplemented nutraceuticals derived from food sources are surmised to improve the human health through interaction with gastrointestinal bacteria. However, lack of fundamental quality control and authoritative consensus (e.g. formulation, route administration, dose dosage regimen) these non-medical yet bioactive compounds one main practical issues resulting in inconsistent individual responsiveness confounded clinical outcomes consuming nutraceuticals. Herein, we studied effects widely...
ABSTRACT Pharmacogenomics stands as a pivotal driver toward personalized medicine, aiming to optimize drug efficacy while minimizing adverse effects by uncovering the impact of genetic variations on inter-individual outcome variability. Despite its promise, intricate landscape metabolism introduces complexity, where correlation between response and genes can be shaped numerous nongenetic factors, often exhibiting heterogeneity across diverse subpopulations. This challenge is particularly...
The development of clinically accessible biomarkers is critical for the early diagnosis gastric cancer (GC) in patients. High-throughput proteomics techniques could not only effectively generate a serum peptide profile but also provide new approach to identify potentially diagnostic and prognostic In this study, we aim discriminating GC. discovery cohort, screened potential using magnetic-bead-based purification matrix-assisted laser desorption/ionization time-of-flight mass spectrometry 64...
Thresholding variable plays a crucial role in subgroup identification for personalized medicine. Most existing partitioning methods split the sample based on one predictor variable. In this paper, we consider setting splitting rule from combination of multivariate predictors, such as latent factors, principle components, and weighted sum predictors. Such subgrouping method may lead to more meaningful population than using single addition, our is change point regression model thus yields...
In this paper, poly(vinyl alcohol)-poly(acrylic acid) based transparent semi-interpenetrating network (semi-IPN) hydrogels were synthesized by using a solvent mixture of dimethyl sulfoxide and deionized water via free radical polymerization subsequent freeze-thaw technique. The formation the semi-IPN was conformed from FT-IR spectra. acrylic acid concentration effect on investigated in terms transparency, crystalline structure thermal stability UV-visible spectroscopy, X-ray diffraction...
Growing evidence has shown the oncogenic function of matrix metallopeptidase 7 (MMP7) in various tumors. However, no systemic pan-cancer analysis on association between MMP7 and different cancers based big clinical data is available. TIMER2, GEPIA2, UALCAN, cBioPortal, String, Metascape, other web databases were searched present study. Generally, expression significantly upregulated most The Cancer Genome Atlas (TCGA) cancer types compared to paired normal controls, yet downregulated tumor...
Disulfide bond A oxidoreductase-like protein (DsbA-L) drives acute kidney injury (AKI) by directly upregulating the expression of voltage-dependent anion-selective channels in proximal tubular cells. However, role DsbA-L immune cells remains unclear. In this study, we used an LPS-induced AKI mouse model to assess hypothesis that deletion attenuates and explore potential mechanism action. After 24 hours LPS exposure, knockout group exhibited lower serum creatinine levels compared WT group....
Abstract Background: T cell dysfunction, which includes exhaustion, anergy, and senescence, is a distinct differentiation state that occurs after antigen exposure. Although dysfunction has been cornerstone of cancer immunotherapy, its potential in transplant research, while not yet as extensively explored, attracting growing interest. Interferon regulatory factor 4 (IRF4) shown to play pivotal role inducing dysfunction. Methods: A novel ultra-low-dose combination Trametinib Rapamycin,...
Surgical management of gastric gastrointestinal stromal tumors (GISTs) has evolved towards minimal invasiveness. Laparoscopic wedge resection and laparoscopic endoscopic cooperative surgery had been considered as standard surgical treatments for GISTs > 2 cm. However, stomach deformation the full-thickness defect caused by these procedures may increase risk morbidity. To address problems, we developed a novel technique, third space robotic (TS-RECS), which could dissect tumor entirely while...