A5067009833- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Transplantation: Methods and Outcomes
- Immune cells in cancer
- Organ Donation and Transplantation
- Acute Kidney Injury Research
- Liver Disease and Transplantation
- Mast cells and histamine
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Inflammation biomarkers and pathways
- PI3K/AKT/mTOR signaling in cancer
- Organ and Tissue Transplantation Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrolyte and hormonal disorders
- CAR-T cell therapy research
- Vitamin D Research Studies
- HIV/AIDS drug development and treatment
- Galectins and Cancer Biology
- IL-33, ST2, and ILC Pathways
- Mechanical Circulatory Support Devices
Second Xiangya Hospital of Central South University
2015-2025
Central South University
2015-2025
Guangxi University
2023-2025
First Affiliated Hospital of Henan University
2023
Zhengzhou People's Hospital
2023
Guangxi Medical University
2023
University of Pittsburgh
2017-2021
Xiamen University
2010-2013
Changsha Medical University
1992
Although a key role of cross‐dressing has been established in immunity to viral infection and more recently the instigation transplant rejection, its tolerance is unclear. We investigated intragraft dendritic cells (DCs) mouse major histocompatibility complex (MHC)‐mismatched liver that occurs without therapeutic immunosuppression. donor interstitial DCs diminished rapidly after transplantation, they were replaced by host peaked on postoperative day (POD) 7 persisted indefinitely....
Abstract The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune that affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell survival, counteracting inflammation. Its role in renal injury, particular, unilateral ureteral obstruction (UUO) or ischemia-reperfusion injury (IRI)-induced remains unclear. In our study, WT Trem2 −/− mice were employed to evaluate the of TREM2 macrophage infiltration tissue after UUO. Bone marrow-derived macrophages...
Alarmins, sequestered self-molecules containing damage-associated molecular patterns, are released during tissue injury to drive innate immune cell proinflammatory responses. Whether endogenous negative regulators controlling early responses also at the site of is poorly understood. Herein, we establish that stromal cell–derived alarmin interleukin 33 (IL-33) a local factor directly restricts capacity graft-infiltrating macrophages after transplantation. By assessing heart transplant...
Regulatory dendritic cells (DCreg) promote transplant tolerance following their adoptive transfer in experimental animals. We investigated the feasibility, safety, fate, and impact on host T of donor monocyte-derived DCreg infused into prospective, living liver patients, 7 days before transplantation. The expressed a tolerogenic gene transcriptional profile, high cell surface programed death ligand-1 (PD-L1):CD86 ratios, IL-10/no IL-12 productivity poor ability to stimulate allogeneic...
Liver interstitial dendritic cells (DCs) have been implicated in the control of ischemia–reperfusion injury (IRI) and host immune responses following liver transplantation. Mechanisms underlying these regulatory functions hepatic DCs remain unclear. We shown recently that transmembrane immunoadaptor DNAX‐activating protein 12 kDa (DAP12) negatively regulates mouse DC maturation proinflammatory stimulatory functions. Here, we used PCR analysis flow cytometry to characterize expression DAP12...
Abstract Macrophages play a crucial role in the immune response during allograft rejection organ transplantation. Therefore, our study aimed to explore genomic features of macrophages mouse heart transplants and use single-cell RNA sequencing investigate Galectin-9 (Gal-9, Lgals9), lectin that can mediate activation differentiation cells through ligand-receptor interactions, effects its regulation We discovered new subset called "Myoz2+ macrophages", which specifically expressed genes...
Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed predict incidence DGF evaluate its effect on survival.This retrospective study kidney was conducted from January 1, 2018, December 31, 2019, at Second Xiangya Hospital Central South University. classified recipients whose operations were performed different years into training validation cohorts used data cohort analyze predictors DGF....
Regulatory T cell (Treg) therapy is a promising approach to amelioration of allograft rejection and promotion organ transplant tolerance. However, the fate infused Treg, how this relates their therapeutic efficacy using different immunosuppressive regimens poorly understood. Our aim was analyze tissue distribution, persistence, replicative activity phenotypic stability autologous, donor antigen alloreactive Treg (darTreg) in anti-thymocyte globulin (ATG)-lymphodepleted, heart-allografted...
Disulfide bond A oxidoreductase-like protein (DsbA-L) drives acute kidney injury (AKI) by directly upregulating the expression of voltage-dependent anion-selective channels in proximal tubular cells. However, role DsbA-L immune cells remains unclear. In this study, we used an LPS-induced AKI mouse model to assess hypothesis that deletion attenuates and explore potential mechanism action. After 24 hours LPS exposure, knockout group exhibited lower serum creatinine levels compared WT group....
The relationship between vitamin E supplementation and the prevalence of chronic kidney disease (CKD) is unclear. We discussed intake CKD further investigated effect on different risk strata.We ultimately included 20 295 participants from National Health Nutrition Examination Survey (NHANES) database 2009 to 2016. Multiple logistic regression restricted cubic splines (RCS) were applied explore stratification. Subgroup analysis was assess stability association CKD.In study, we found a...
Pediatric kidney donors remain underutilized due to the high risk of postoperative thrombosis. To address this problem, we developed a novel en bloc transplantation technique using donor thoracic aorta and distal abdominal as inflow outflow tracts, respectively. Briefly, eight kidneys from deceased infant under five months old with low body weight (1.9-4.9 kg) were transplanted into four pediatric adult patients. The donor's common iliac artery or external was anastomosed recipient's...
In myeloid dendritic cells (DC), deletion of the mechanistic target rapamycin complex 2 (TORC2) results in an augmented pro-inflammatory phenotype and T cell stimulatory activity; however, underlying mechanism has not been resolved. Here, we demonstrate that mouse bone marrow-derived TORC2-deficient DC (TORC2-/- DC) utilize altered metabolic program, characterized by enhanced baseline glycolytic function compared to wild-type WT control (Ctrl) DC, increased dependence on ATP production,...
In Brief Background Little is known about how new-generation adenosine triphosphate–competitive mechanistic target of rapamycin (mTOR) kinase inhibitors affect immunity and allograft rejection. Methods mTOR complex (C) 1 2 signaling in dendritic cells T was analyzed by Western blotting, whereas immune cell populations normal heart recipient mice were flow cytometry. Alloreactive proliferation quantified mixed leukocyte reaction; intracellular cytokine production serum antidonor IgG levels...