A5103339164- Liver Disease Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Prostate Cancer Treatment and Research
- Liver Disease and Transplantation
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Hepatocellular Carcinoma Treatment and Prognosis
- Urinary Tract Infections Management
- Urinary and Genital Oncology Studies
- Immune Cell Function and Interaction
- Urinary Bladder and Prostate Research
- Pediatric Urology and Nephrology Studies
- Immunotherapy and Immune Responses
- Testicular diseases and treatments
- Renal cell carcinoma treatment
- Hepatitis Viruses Studies and Epidemiology
- Kidney Stones and Urolithiasis Treatments
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Medical Imaging and Pathology Studies
- Organ Transplantation Techniques and Outcomes
- Pelvic floor disorders treatments
Ehime University
2016-2025
Shionogi (Japan)
2006-2025
YKK (Japan)
2023-2025
Futaba (Japan)
2002-2023
Mito Saiseikai General Hospital
2004-2023
Evidence (Italy)
2023
Michigan Department of Education
2023
American Urological Association
2023
Tsukuba International University
2019-2022
Rakuno Gakuen University
2011-2021
In response to low ambient temperature, mammalian cells as well microorganisms change various physiological functions, but the molecular mechanisms underlying these adaptations are just beginning be understood. We report here isolation of a mouse cold-inducible RNA-binding protein (cirp) cDNA and investigation its role in cold-stress cells. The cirp encoded an 18-kD consisting amino-terminal RNAbinding domain carboxyl-terminal glycine-rich exhibited structural similarity class stress-induced...
Primers to amplify the genes encoding virulence factors of uropathogenic Escherichia coli, such as pilus associated with pyelonephritis (pap), haemolysin (hly), aerobactin (aer) and cytotoxic necrotizing factor 1 (cnf1) genes, were designed. The above primers along previously reported for S fimbriae (sfa) afimbrial adhesin I (afaI) combined develop a multiplex polymerase chain reaction (PCR) detection respective identification E. coli. PCR detect pap, sfa, afaI, hly, aer cnf1 was highly...
The fecal-perineal-urethral hypothesis to explain the cause of urinary tract infections (UTI) by enteric bacteria has been supported longitudinal studies using methods serotyping and detecting urovirulence factors such as P fimbriae. However, genetic techniques more accurately characterize Escherichia coli strains have not exploited.A total 2,700 E. colonies isolated from urine rectal swabs 9 female subjects with acute uncomplicated cystitis 30 healthy women were serotyped examined for genes...
It is now widely accepted that factors other than androgen are crucial in the normal and abnormal growth of prostate, including human benign prostatic hyperplasia (BPH). Using a Northern blot analysis, we examined hyperplastic prostates for expressions basic fibroblast factor (FGF), acidic FGF, transforming type beta 2 (TGF-beta 2), TGF-beta 1, epidermal (EGF). Basic FGF mRNAs were detectable all examined. In addition, levels expression significantly higher BPH prostate. Acidic transcripts...
A nationwide survey on urolithiasis in Japan between 1965 through 1987 was carried out, succeeding the previous 1955 and 1966 studies, an effort to evaluate chronological geographical changes among Japanese people who are relatively racially homogenous living with similar customs habits, which have changed dramatically from old westernized modes a very short period after Second World War. Incidence of calcium-containing urinary stones upper tract has been increasing since War westernization...
Abstract To study the possible involvement of reactive oxygen species (ROS) in tumor biology human renal‐cell carcinoma (RCC), we analvzed 35 cases RCC for 2 parameters oxidative damage: 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG), a mutation‐prone DNA‐ base ‐modified product, was measured by means high‐performance liquid chromatography (HPLC) with an electrochemical (EC) detector, and 4‐hydroxy‐2‐nonenal (HNE)‐modified proteins were poly‐clonal antibody against HNE‐modified proteins. A 54% higher...
Although a key role of cross‐dressing has been established in immunity to viral infection and more recently the instigation transplant rejection, its tolerance is unclear. We investigated intragraft dendritic cells (DCs) mouse major histocompatibility complex (MHC)‐mismatched liver that occurs without therapeutic immunosuppression. donor interstitial DCs diminished rapidly after transplantation, they were replaced by host peaked on postoperative day (POD) 7 persisted indefinitely....
No AccessJournal of UrologyClinical Urology: Urological Neurology and Urodynamics1 Feb 1997Diabetic Cystopathy: Relationship to Autonomic Neuropathy Detected by Sympathetic Skin Response Tomohiro Ueda, Naoki Yoshimura, Osamu Yoshida UedaTomohiro Ueda , YoshimuraNaoki Yoshimura YoshidaOsamu View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65209-1AboutFull TextPDF ToolsAdd favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract...
Abstract Background : Urinary incontinence (UI) is a common problem in adults, especially among the elderly. We examined prevalence and risk factors of UI potential hindering individuals from seeking treatment for community‐dwelling population aged over 40 years. Methods Data were collected by mailing 23‐item urinary questionnaire to random sample 40–75 years ( n = 3500) seven towns Shiga Prefecture, Japan. Collected data then used estimate provide information regarding subtypes UI,...
Occludin is the only integral membrane protein identified to date as a component of tight junctions (TJs). Here, we examined distribution and expression occludin in murine testis bearing well-developed TJ. In adult mouse testis, was concentrated at TJ strands, which are located most basal regions lateral membranes Sertoli cells. immunoblotting, showed characteristic multiple banding pattern, suggesting that highly phosphorylated testis. 1-wk-old distributed diffusely cells, even this stage,...
The prognostic value of prostate specific antigen was evaluated to predict disease progression after endocrine therapy in patients with prostatic cancer. A total 73 studied (6 stage B2, 16 C, 9 D1 and 42 D2 disease). Endocrine included bilateral orchiectomy, diethylstilbestrol diphosphate luteinizing hormone-releasing hormone analogue. Pre-treatment serum levels were determined all an enzyme immunoassay kit. During a followup 4 68 months (average 24 months) clinical occurred the patients....
No AccessJournal of Urology1 Apr 1988Measurement Multidrug-Resistance Messenger RNA in Urogenital Cancers; Elevated Expression Renal Cell Carcinoma is Associated with Intrinsic Drug Resistance Yoshiyuki Kakehi, Hiroshi Kanamaru, Osamu Yoshida, Hiroaki Ohkubo, Shigetada Nakanishi, Michael M. Gottesman, and Ira Pastan KakehiYoshiyuki Kakehi , KanamaruHiroshi Kanamaru YoshidaOsamu Yoshida OhkuboHiroaki Ohkubo NakanishiShigetada Nakanishi GottesmanMichael Gottesman PastanIra View All Author...
Pellets weighing 20 to 24 milligrams and containing percent sodium saccharin suspended in cholesterol were surgically implanted into the urinary bladder lumens of female Swiss mice (60 90 days old) under ether anesthesia. Incidences mouse carcinomas animals exposed these pellets 47 52 as compared with incidences 13 12 control pure cholesterol. The exposure was very brief, because time required for 50 compound be eluted from about 5.5 hours.
Context Current drugs for chronic hepatitis B therapy have a poor efficacy in terms of post-treatment sustained viral suppression and generate important side effects during after therapy. Therapeutic vaccination with HBV antigens is an attractive alternative to test. Objective Evaluating the therapeutic vaccine candidate (designated NASVAC) containing both surface antigen (HBsAg) core (HBcAg) versus pegylated interferon (Peg-IFN) naïve patients. Design, setting, participants An open phase...
Significance Gene therapy has made significant strides in the treatment and even cure of single-gene defects. However, maturation this field will require more sophisticated vehicles capable cell-selective delivery large genetic payloads whose regulated expression restore or enhance cellular functionality. High-capacity herpes simplex virus vectors have potential to meet these challenges but been limited by need preserve one particularly cytotoxic viral product, infected cell polypeptide 0,...
Between July 1992 and October 1996, 100 transperitoneal laparoscopic adrenalectomies were performed on 99 patients at our hospital affiliated hospitals. The clinical diagnoses primary aldosteronism (41 patients), Cushing's syndrome (15), pre-Cushing's (6), pheochromocytoma (7; 8 adrenal glands), cancer (2), nonfunctioning adenoma (22), myelolipoma (3), complicated cyst (3). Ninety-seven glands removed laparoscopically. mean operative time was 240 ± 76 (SD) minutes the blood loss 68 80 mL for...
Background The prevalence of lower urinary tract symptoms was determined by survey as an initial step in estimating the significance benign prostatic hyperplasia (BPH) Asia and Australia. Methods symptom index (0 to 35) quality‐of‐life (QOL) 6) international prostate score were measured 7588 men 9 Asian countries 146 Results percentages considered be symptomatic (symptom ≧ 8) 18%, 29%, 40%, 56% age groups 40 49, 50 59, 60 69, 70 79 years, respectively. For Australian men, these figures 36%,...
Abstract To investigate the roles of allelic loss in development urothelial cancer, heterozygosity was examined on 7 chromosomal arms 49 cases cancer various grades and stages. Loss found alleles order frequency as follows: 9q (21/38, 55%), 11p (20/44, 45%), 17p (18/42,43%), 13q (10/39,26%), 3p (8/41, 20%), 10q 2/29, 7%) 1p (1/36, 3%). lnvasive (high‐grade or ≥pT2) tumors showed (13/16,81%) (7/16, 44%) with significantly higher frequencies than non‐invasive (grade 1‐2 ≤ p TI ) tumors....
No AccessJournal of UrologyClinical Urology: Original Article1 Jan 1996Urinary Calculi as a Late Complication the Indiana Continent Urinary Diversion: Comparison with Kock Pouch Procedure Akito Terai, Tomohiro Ueda, Yoshiyuki Kakehi, Toshiro Terachi, Yoichi Arai, Yusaku Okada, and Osamu Yoshida TeraiAkito Terai , UedaTomohiro Ueda KakehiYoshiyuki Kakehi TerachiToshiro Terachi AraiYoichi Arai OkadaYusaku Okada YoshidaOsamu View All Author...