A5103156672- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Pneumocystis jirovecii pneumonia detection and treatment
- Organ and Tissue Transplantation Research
- Antifungal resistance and susceptibility
- Transplantation: Methods and Outcomes
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- COVID-19 Impact on Reproduction
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Bone and Joint Diseases
- Acute Kidney Injury Research
- Antibiotics Pharmacokinetics and Efficacy
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Pancreatic function and diabetes
- Pharmacological Effects and Toxicity Studies
- Bone Metabolism and Diseases
- Liver Disease and Transplantation
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Medical Imaging and Pathology Studies
Second Xiangya Hospital of Central South University
2009-2025
Central South University
2011-2025
Xiangya Hospital Central South University
2018-2021
Beijing Tongren Hospital
2007
The aims of the present study were to characterize pharmacokinetics voriconazole in renal transplant recipients and identify factors significantly affecting pharmacokinetic parameters. We also aimed explore optimal dosing regimens for patients who developed invasive fungal infections.
Poor skin wound healing, which is common in patients with diabetes, related to imbalanced macrophage polarization. Here, we find that nutrition sensor GCN2 (general control nonderepressible 2) and its downstream are significantly upregulated human tissue mouse macrophages, but wound-related expression activity downregulated by diabetes hyperglycemia. Using healing models of GCN2-deleted mice, bone marrow chimeric monocyte-transferred show deletion macrophages delays compared wild-type mice...
To investigate the clinical characteristics, diagnosis and treatment of tuberculosis infection after deceased donor kidney transplantation to analyze risk factors prognosis through a paired case–control study. This study investigated 31 transplant recipients who developed among 2185 total during 2012–2021. We employed 1:1 design, utilizing patients received kidneys from same as controls. The analyzed presentation, diagnosis, treatment, factors, prognosis. identified 1.4% incidence (TB)...
Whether induced tissue-resident memory T (T RM ) cells in nonlymphoid organs alone can mediate allograft rejection is unknown. By grafting alloskin or heart into severe combined immunodeficient Rag2KO mice which a piece of CD4 + and/or CD8 cell–containing MHC-matched syngeneic skin was transplanted advance, we addressed this issue. The the acutely rejected grafts. RNA-seq analysis showed that favorably differentiated H 17-like polarization during secondary immune response. Inhibition key 17...
End-stage renal disease (ESRD) patients usually develop extensive and progressive vascular calcification, lots of calcification inhibitors as well procalcifying factors are involved in the process. However, mechanisms ESRD still ill-defined. In present study, we found that plasma exosomes derived from (ESRD-Ex) promoted smooth muscle cells (VSMCs) significantly, while transplant recipients (RTR-Ex) could partially attenuate VSMCs calcification. Moreover, protein concentration ESRD-Ex was...
Tacrolimus is an immunosuppressant with a narrow therapeutic window. exposure increased significantly during voriconazole co-therapy. The magnitude of this interaction highly variable, but it hard to predict quantitatively. We conducted study on 91 kidney transplantation recipients Furthermore, 1701 tacrolimus concentration data were collected. Standard adjusted by daily dose (C/D) and weight-adjusted standard (CDW) 6 times higher C/D CDW concentration. Patients the genotype CYP3A5 *3/*3...
Abstract Thymic epithelial cells (TECs) are critical for the development and generation of functionally competent T cells. Until now, mechanism that regulates survival TECs is poorly understood. In current study, we found Tsc1 controls homeostasis medullary (mTECs) by inhibiting lysosomal-mediated apoptosis pathway in mice. TEC-specific deletion predominately decreased cell number mTECs and, to a lesser content, affected cortical TECs. The defect caused deficiency mice impaired thymocyte...
Significant increase in tacrolimus exposure was observed during co-administration with voriconazole, and no population pharmacokinetic model exists for renal transplant recipients receiving voriconazole. To achieve target concentrations, an optimal dosage regimen is required. This study aims to develop individualized dosing parameters through analysis simulate concentrations under different regimens.
The colon plays a vital role in the disposal of nitrogenous waste products. Therefore, may provide therapeutic target for managing chronic kidney disease (CKD).To evaluate efficacy simplified model colonic dialysis with hemodialysis solutions (SCD) to delay progression stages 3-5 CKD.Retrospective study.We retrospectively analyzed 178 CKD patients who did or not receive SCD (SCD group, n = 88; control 90). follow-up was 36 months. outcome defined as decrease 50% more estimated glomerular...
Purpose This study is aimed at developing a molecular diagnostics platform to enhance the interpretation of renal allograft biopsies using quantitative proteomic profiling formalin‐fixed and paraffin‐embedded (FFPE) specimens. Experimental Design A proteomics composed 1) an optimized FFPE protein sample preparation method, 2) tandem mass tag TMT10‐plex‐based workflow, 3) systematic statistical analysis pipeline reveal differentially expressed proteins has been developed. then tested on small...
Voriconazole is the mainstay for treatment of invasive fungal infections in patients who underwent a kidney transplant. Variant CYP2C19 alleles, hepatic function, and concomitant medications are directly involved metabolism voriconazole. However, drug also associated with numerous adverse events. The purpose this study was to identify predictors events using binary logistic regression measure its trough concentration multiple linear modeling. We conducted prospective analysis 93 recipients...
Background Patients after kidney transplantation need to take long-term immunosuppressive and other drugs. Some of these drug side effects are easily confused with the symptoms Fanconi syndrome, resulting in misdiagnosis missed diagnosis, causing serious consequences patients. Therefore, improving awareness, early diagnosis treatment syndrome is critical. Methods This retrospective study analyzed 1728 cases allogeneic transplant patients admitted Second Xiangya Hospital Central South...
Kidney transplantation from donors who weigh ≤5 kg is performed at only a few transplant centers owing to the high complication and low graft survival rates associated with this approach. We retrospectively compared results of kidney our center between January 2015 December 2019 based on following pediatric donor criteria: body weight (n=32), 5 kg< ≤20 (n=143), >20 (n=110). also perform subgroup analysis outcomes donors, using conventional (dual separate classic en-bloc KTx)/novel (en-bloc...
Background Toxicity is a major concern related to the clinical use of polymyxin B, and available safety data for renal transplant patients are limited. Aims We investigated B toxicity risk factors in patients. Methods A prospective study was performed on group who received intravenous between January 2018 August 2021. Polymyxin treatment monitored evaluate factors. Results total 235 courses were administered 213 Of these, 121 (51.5%) developed skin hyperpigmentation (SH), 149 (63.4%)...