A5026457044- Curcumin's Biomedical Applications
- Genomics, phytochemicals, and oxidative stress
- Mycotoxins in Agriculture and Food
- Total Knee Arthroplasty Outcomes
- Pancreatic function and diabetes
- Metal-Organic Frameworks: Synthesis and Applications
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Animal Nutrition and Physiology
- Heme Oxygenase-1 and Carbon Monoxide
- Toxin Mechanisms and Immunotoxins
- Orthopedic Surgery and Rehabilitation
- Carcinogens and Genotoxicity Assessment
- Frailty in Older Adults
- Eating Disorders and Behaviors
- Peroxisome Proliferator-Activated Receptors
- Carbon Nanotubes in Composites
- Periodontal Regeneration and Treatments
- Autophagy in Disease and Therapy
- Advanced Photocatalysis Techniques
- Bioinformatics and Genomic Networks
- Social and Intergroup Psychology
- RNA modifications and cancer
Second Xiangya Hospital of Central South University
2022-2025
Central South University
2022-2025
Northeast Agricultural University
2017-2024
Zhejiang A & F University
2022-2024
Nanchang University
2024
Shenzhen Institutes of Advanced Technology
2024
Wuhan University
2022-2024
Chinese Academy of Sciences
2022-2024
University of Chinese Academy of Sciences
2022-2024
Zhejiang University
2024
A synthetic circuit implementing density-controlled bacterial motility autonomously produces a tunable stripe pattern.
As a type of heterogeneous catalyst expected for the maximum atom efficiency, series single-atom catalysts (SACs) containing spatially isolated metal single atoms (M-SAs) have been successfully prepared by confining M-SAs in pore-nanospaces porphyrinic metal–organic frameworks (MOFs). The MOF composites M-SAs@Pd-PCN-222-NH2 (M = Pt, Ir, Au, and Ru) display exceptionally high persistent efficiency photocatalytic hydrogen evolution reaction with turnover number (TON) up to 21713 32 h...
Mycoplasma pneumoniae (MP) is one of the most common pathogenic organisms causing upper and lower respiratory tract infections, lung injury, even death in young children. Toll-like receptors (TLRs) play an important role innate immunity by allowing host to recognize pathogens invading body. Previous studies demonstrated that TLR4 a potential therapeutic target for treatment MP pneumonia. Therefore, present study aimed screen biologically active ingredients receptor pathway. We first used...
The electrocatalytic CO2 reduction reaction (CO2RR) to produce multicarbon (C2+) products such as ethylene (C2H4) is a promising method achieve carbon neutrality, but it very difficult due the high activation barrier of and low selectivity CO2RR especially for C2+ products. Herein, copper single atoms (Cu-SAs) were confined into nanospace an iridium porphyrin-based metal–organic framework (Ir-PCN-222) form (MOF) composite (Cu-SAs@Ir-PCN-222-PA) with dual active sites Ir-porphyrin Cu-SAs...
This study set out to assess the mitigative effects of curcumin on AFB1-induced necroptosis and inflammation in chicken liver. Ninety-six one-day-old AA broiler chickens were separated into four groups, including control group, AFB1 (1 mg/kg) (300 + group group. After 28 days treatment, livers collected for different experimental analyses. The morphological observation results showed obvious necrotic characteristics, cell swelling, rupture mitochondrial membranes livers. exposure increased...
Fatty acids (FAs) are widely involved in diverse biological functions. In mice with myeloid-specific deletion of fatty acid-binding protein 5 (FABP5), OVA-induced allergic airway inflammation (AAI) is significantly exacerbated by increasing alternatively activated macrophages (M2). Fabp5 deficiency increases IL-4-induced M2 vitro. macrophages, causes significant accumulation free long-chain unsaturated FAs, such as oleic acid, but does not cause detectable changes to other groups FAs....
Cytochrome P450 enzymes are often responsible for the toxic and carcinogenic effects of toxicants, such as aflatoxin B1 (AFB1). The human hepatic CYP2A6 enzyme mediates oxidative metabolism several procarcinogens. In this study, we characterized a partial sequence gene from Arbor Acres (AA) broiler studied its role in AFB1 bioactivation. Moreover, effect curcumin on is illustrated. Six groups AA were treated 28 days including control group (fed only basal diet), alone-treated (450 mg/kg...
Aflatoxin B1 (AFB1) is a potent hepatotoxic and carcinogenic agent. Curcumin possesses potential anti-inflammatory, anti-oxidative hepatoprotective effects. However, the role of LncRNAs in protective mechanisms curcumin against AFB1-induced liver damage still elusive. Experimental broilers were randomly divided into 1) control group, 2) AFB1 group (1 mg/kg feed), 3) cur + plus 300 diet) 4) (300 diet). Liver transcriptome analyses qPCR performed to identify shifts genes expression. In...
Poor skin wound healing, which is common in patients with diabetes, related to imbalanced macrophage polarization. Here, we find that nutrition sensor GCN2 (general control nonderepressible 2) and its downstream are significantly upregulated human tissue mouse macrophages, but wound-related expression activity downregulated by diabetes hyperglycemia. Using healing models of GCN2-deleted mice, bone marrow chimeric monocyte-transferred show deletion macrophages delays compared wild-type mice...
A new nanothermometer design that uses nitrogen vacancy centers in nanodiamonds and a magnetic nanoparticle improves on the sensitivity of similar devices by 1 order magnitude over wide range working temperatures. The experiment also observes phase transition single particle first time.
It has been reported that oral intake of aflatoxin B1 (AFB1)-contaminated feed could cause acute, sub-chronic, or chronic toxicity in livestock and poultry. However, the harmful effect AFB1 on small intestine is still controversial. Therefore, blocking entry into body through digestive tract one important methods to prevent its toxicity. In present study, 1-day-old Arbor Acres broilers were randomly divided 6 groups including control group, curcumin group (450 mg curcumin/kg feed), low-,...
Fatty acid binding protein 5 (FABP5) is mainly involved in the uptake, transport, and metabolism of fatty cytoplasm, its role immune cells has been recognized recent years. However, FABP5 macrophage inflammation underlying mechanisms were not fully addressed. In our study, acute liver injury sepsis mouse models induced by i.p. injection LPS cecal contents, respectively. Oleic (0.6 g/kg) was injected four times intragastric administration every week, this lasted for 1 wk before or content...
The purpose of this study was to explore how the congruence between academic pressure and psychological imbalance affects depressive symptoms in adolescents further grade-level differences these effects among high school students. population consisted 29,975 students from 20 schools Liuyang City, Hunan Province. Mental Health Scale for Secondary School Students (MSSMHS) Self-Depression (SDS) were used assess pressure, symptoms. examined by polynomial regression response surface analysis....
Understanding the mechanism of chondrocytes degeneration could provide a new potential therapeutic idea for rheumatoid arthritis (RA) treatment. MicroRNA-27b-3p (miR-27b-3p) has been shown to regulate variety cell behaviors in various types. However, role miR-27b-3p RA remains unknown.Expression and HIPK2 cartilage tissues was characterized using qRT-PCR Western blot. MiR-27b-3p overexpressed or suppressed observe miR-27b-3p.We found declined elevated cells qRT-PCR. Dual-luciferase reporter...
In this study, we examined the protective effects of curcumin against AFB1-induced immune response and pathological changes in broilers. Histopathology examinations showed that at day 28, AFB1 (5 mg/kg) exposure leads to severe histological spleen, thymus bursa Fabricius with a decrease number karyoplasmic area ratio plasma cells. Curcumin alleviated organs’ damage as well cells dose-dependent manner. RT-PCR data significantly downregulated IL-2 IFN-γ mRNA expression levels thymus, spleen...
Phenanthrene (PHE) is one of the most abundant polycyclic aromatic hydrocarbons (PAHs), which a widespread environmental contaminant. Various studies showed that PHE has adverse impacts on animals and human health. It been shown exposure induced follicular atresia endocrine dyscrasia in female mice. However, potential mechanism regarding how affects reproductive system especially oocyte quality not elucidated.In this study, we set up model found compromised oocytes maturation competence by...
The purpose of this study was to investigate the role epigenetic DNA methylation and CYPs expression in AFB1-exposed broiler liver protective effect curcumin. Sixty-four one-day-old AA broilers were randomly divided into four groups, including control group, AFB1 group (1 mg/kg AFB1), curcumin + curcumin) (300 curcumin). Histological observation, CYP450 enzyme activities, levels methyltransferases enzymes, overall level investigated. Dietary found induce severe injury broilers, upregulate...