A5080560831- Prion Diseases and Protein Misfolding
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical Acid Research Studies
- Calcium signaling and nucleotide metabolism
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Inflammasome and immune disorders
- Neurological diseases and metabolism
- Mitochondrial Function and Pathology
- Trace Elements in Health
- interferon and immune responses
- Belt and Road Initiative
- Nuclear Receptors and Signaling
- Liver Disease and Transplantation
- Genetic Neurodegenerative Diseases
- Lung Cancer Diagnosis and Treatment
- Quinazolinone synthesis and applications
- International Development and Aid
- Gastrointestinal disorders and treatments
- Immune Response and Inflammation
- Pleural and Pulmonary Diseases
Case Western Reserve University
1985-2024
University School
2023-2024
Islamia University of Bahawalpur
2022-2024
Sindh Institute of Urology and Transplantation
2021-2023
COMSATS University Islamabad
2019-2022
China Agricultural University
2015-2020
University of Veterinary and Animal Sciences
2014-2020
University of South Florida
2020
University of Tampa
2020
Ayub Medical College
2017-2019
Mycoplasma pneumoniae (MP) is one of the most common pathogenic organisms causing upper and lower respiratory tract infections, lung injury, even death in young children. Toll-like receptors (TLRs) play an important role innate immunity by allowing host to recognize pathogens invading body. Previous studies demonstrated that TLR4 a potential therapeutic target for treatment MP pneumonia. Therefore, present study aimed screen biologically active ingredients receptor pathway. We first used...
Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein, spongiform changes in brain, and brain inflammation as a result wide-spread activation microglia. Autophagy is highly conserved catabolic process for clearance cytoplasmic components, including protein aggregates damaged organelles; this also eliminates pathological PrPSc it accumulates during infection. The NALP3 inflammasome multiprotein complex that component innate immune system...
Abstract Prion diseases caused by the cellular prion protein (PrP C ) conversion into a misfolded isoform Sc are associated with multiple mitochondrial damages. We previously reported dynamic abnormalities and cell death in via modulation of variety factors. Optic atrophy 1 (OPA1) is one factors that control fusion, DNA (mtDNA) maintenance, bioenergetics, cristae integrity. In this study, we observed downregulation OPA1 disease models vitro vivo, mitochondria structure damage dysfunction,...
Nilotinib, a tyrosine kinase inhibitor, has been studied extensively in various tumor models; however, no information exists about the pharmacological action of nilotinib bacterial infections. Mycobacterium bovis (M. bovis) and avium subspecies paratuberculosis (MAP) are etiological agents bovine tuberculosis Johne’s disease, respectively. Although M. MAP cause distinct tissue tropism, both them infect, reside, replicate mononuclear phagocytic cells infected host. Autophagy is an innate...
Evidence of the gut microbiota influencing neurodegenerative diseases has been reported for several neural diseases. However, there is little insight regarding relationship between and prion disease. Here, using fecal samples 12 prion-infected mice 25 healthy controls, we analyzed structure metabolic changes by 16S rRNA sequencing LC-MS–based metabolomics respectively as multi-omic analyses. Additionally, SCFAs common amino acids were detected GC–MS UPLC respectively. Enteric induced disease...
Mycobacterium bovis is the causative agent of tuberculosis in a wide range mammals, including humans. Macrophages are first line host defense. They secrete proinflammatory cytokines, such as interleukin-1 beta (IL-1β), response to mycobacterial infection, but underlying mechanisms by which human macrophages activated and release IL-1β following M. infection poorly understood. Here we show that 'nucleotide binding oligomerization domain-like receptor (NLR) family pyrin domain containing 7...
Mycobacterium avium subspecies paratuberculosis (MAP) persistently survive and replicate in mononuclear phagocytic cells by adopting various strategies to subvert host immune response. Interleukin-10 (IL-10) upregulation via inhibition of macrophage bactericidal activity is a critical step for MAP survival pathogenesis within the cell. Mitogen activated protein kinase p38 (MAPK-p38) signaling cascade plays crucial role elevation IL-10 progression pathogenesis. The contribution miRNAs their...
Despite its ambitious "economic sustainability" objectives, the China-Pakistan Economic Corridor (CPEC) has been subject of growing environmental anxiety. Considering CPEC developments, it is clear that Pakistan ready to fully embrace this new industrial chapter and take advantage major benefits solve social, energy, infrastructure, economic problems. However, should also seriously commit undertaking proper impact assessments upgrading system resilience. Data was collected from 400...
Caveolae-mediated endocytosis regulates cell adhesion and growth in an anchorage-dependent manner. Studies of the endocytic function caveolae have suggested a wide-ranging list cargoes, including number receptors extracellular proteins, ligands nutrients from matrix. Disruption processes caveolae-mediated mediated by signaling proteins is critical to cellular integrity. Caveolin-1 dynamin-2 are 2 major associated with endocytotic function. Mechanistically, has co-equal role caveolin-1 terms...
Prion diseases are neurodegenerative associated with neuron damage and behavioral disorders in animals humans.Melatonin is a potent antioxidant used to treat variety of diseases.We investigated the neuroprotective effect melatonin on prion-induced N2a cells.N2a cells were pretreated 10 μM for 1 hour followed by incubation 100 PrP 106-126 24 hours.Melatonin markedly alleviated -induced apoptosis cells, inhibited mitochondrial abnormality dysfunction, including fragmentation overproduction...
This article examines the developmental collaboration under CPEC to see if stated scenario of developed-country progressive cooperation with developing countries holds true on ground. The economic development is determined by their relationships other including megaprojects like which interlink geographically, socially, and economically. present study has adopted a mixed method technique data for this was gathered using questionnaires one-on-one interviews respondents. Furthermore, Pearson...