A5019724929- Inflammasome and immune disorders
- interferon and immune responses
- Immune Response and Inflammation
- Heme Oxygenase-1 and Carbon Monoxide
- Gut microbiota and health
- Mosquito-borne diseases and control
- Autophagy in Disease and Therapy
- Viral Infections and Vectors
- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- Intensive Care Unit Cognitive Disorders
- Clostridium difficile and Clostridium perfringens research
- Sepsis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
- Autoimmune and Inflammatory Disorders Research
- Cytokine Signaling Pathways and Interactions
- Proteins in Food Systems
- Polysaccharides Composition and Applications
- Gout, Hyperuricemia, Uric Acid
- Neonatal Respiratory Health Research
- Pickering emulsions and particle stabilization
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Meat and Animal Product Quality
Union Hospital
2025
First Affiliated Hospital of Harbin Medical University
2022-2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2024
Southwest University
2012-2024
Huashan Hospital
2024
Fudan University
2015-2024
Harbin Medical University
2022-2024
Fujian Agriculture and Forestry University
2016-2024
In this study, the influence of psyllium husk (PH) on gel properties myofibrillar protein (MP) and corresponding interaction mechanism were investigated. The results indicated that MP could be adjusted by addition PH. At a low PH (0.1–1%, w/w), network was filled, promoting unfolding structure between proteins. dense effectively improved texture property water holding capacity (94.8%) gels. 2% addition, complex interpenetrating composed polysaccharide in formed, showing best properties....
This study identifies interleukin-6 (IL-6)-independent phosphorylation of STAT3 Y705 at the early stage infection with several viruses, including influenza A virus (IAV). Such activation is dependent on retinoic acid-induced gene I/mitochondrial antiviral-signaling protein/spleen tyrosine kinase (RIG-I/MAVS/Syk) axis and critical for antiviral immunity. We generate STAT3Y705F/+ knockin mice that display a remarkably suppressed response to IAV infection, as evidenced by impaired expression...
Purpose Sex hormones are closely linked to inflammation and lipid metabolism. This study explores the correlation of residual cholesterol risk with sex hormones. Materials methods Logistic regression dose-response curve analyses were conducted examine associations total testosterone (TT), Hormone Binding Protein (SHBG), Estradiol (E2), Free (FT) low density lipoprotein (LDL-C) high sensitive c-reactive protein (hs-CRP). Testosterone deficiency, defined as TT below 300 ng/dL, was analyzed...
Avian Tembusu virus (ATMUV) is a newly emerged flavivirus that belongs to the Ntaya group. ATMUV highly pathogenic causing significant economic loss Chinese poultry industry. However, little known about role of host innate immune mechanism in defending against infection. In this study, we found infection significantly up-regulated expression type I and III interferons (IFN) some critical IFN-stimulated genes (ISG) vivo vitro. This response was induced by genomic RNA ATMUV. Furthermore,...
Studies have shown that there are differences between the sexes regarding to occurrence and development of liver diseases, which may be associated with sex hormones. However, mechanisms behind it largely unknown. In this study, we first investigated injury male female mice, using CCl 4 -induced mouse model. It showed damage mice was much more severe than mice. Both acute fibrosis were reduced when androgens depleted by castration The vulnerability testis endocrine excessive activation...
Mycobacterium bovis is the causative agent of tuberculosis in a wide range mammals, including humans. Macrophages are first line host defense. They secrete proinflammatory cytokines, such as interleukin-1 beta (IL-1β), response to mycobacterial infection, but underlying mechanisms by which human macrophages activated and release IL-1β following M. infection poorly understood. Here we show that 'nucleotide binding oligomerization domain-like receptor (NLR) family pyrin domain containing 7...
Autophagy-related protein 7 (ATG7) is an essential autophagy effector enzyme. Although it well known that plays crucial roles in the infections with various viruses including influenza A virus (IAV), function and underlying mechanism of ATG7 infection pathogenesis IAV remain poorly understood. Here, vitro studies showed had profound effects on replication IAV. Depletion markedly attenuated IAV, whereas overexpression facilitated viral replication. conditional knockout mice were further...
Avian Tembusu virus (ATMUV) is a highly pathogenic flavivirus that causes significant economic losses to the Chinese poultry industry. Our previous experiments demonstrated ATMUV infection effectively triggered host innate immune response through MDA5 and TLR3-dependent signaling pathways. However, little information available on role of interferon-stimulated genes (ISGs) in defending against infection. In this study, we found induced robust expression type I III interferon (IFNs) duck...
The emerging avian-origin H7N9 influenza A virus, which causes mild to lethal human respiratory disease, continues circulate in China, posing a great threat public health. Influenza NS1 protein plays key role counteracting host innate immune responses, allowing the virus efficiently replicate host. In this study, we compared amino acid sequences of with those other strains, and determined variability within then evaluated impact substitutions on ability proteins inhibit immunity....
Abstract Influenza A virus can cause acute respiratory infection in animals and humans around the globe is still a major threat to animal husbandry public health. Due antigenic drift shift of virus, development novel anti-influenza strategies has become an urgent task. Here we generated transgenic (TG) mice stably expressing short-hairpin RNA specifically targeting hemagglutinin (HA) influenza investigated susceptibility infection. We found that HA expression was dramatically disrupted TG...
BackgroundSeveral respiratory infections outbreaks have been observed in mainland China after reduction of non-pharmaceutical interventions. Other countries seen increases outside typical seasons post-COVID-19, warranting investigation into underlying causes.MethodsWe established monitoring networks for suspected infection 14 tertiary hospitals nationwide. PCR SARS-CoV-2, influenza A and B were performed on 3708 specimens deep sequencing conducted to identify co-infections or newly emerging...
Heart failure with preserved ejection fraction (HFpEF) is inherently a complex inflammatory syndrome, and heightened inflammation strongly associated an increased risk of death. However, the association systemic levels total cardiovascular death among patients HFpEF remains unknown. We aimed to investigate prognostic impact on all-cause HFpEF.
Abstract Background Sepsis can cause immune dysregulation and multiple organ failure in patients eventually lead to death. The gut microbiota has demonstrated its precise therapeutic potential the treatment of various diseases. This study aimed discuss structural changes with sepsis analyze differences different prognoses. Methods We conducted a multicenter which rectal swab specimens were collected on first third days diagnosis. A total 70 collected, information was obtained by 16S rRNA...