A5017190687- Complementary and Alternative Medicine Studies
- Peripheral Nerve Disorders
- interferon and immune responses
- Pharmacological Effects of Natural Compounds
- Empathy and Medical Education
- Cytokine Signaling Pathways and Interactions
- Pain Management and Placebo Effect
- Cancer Genomics and Diagnostics
- Orthopedic Surgery and Rehabilitation
- Shoulder Injury and Treatment
- Luminescence and Fluorescent Materials
- Immune Cell Function and Interaction
- Geochemistry and Geologic Mapping
- Myofascial pain diagnosis and treatment
- Molecular Sensors and Ion Detection
- Brain Metastases and Treatment
- Macrophage Migration Inhibitory Factor
- Delphi Technique in Research
- Metastasis and carcinoma case studies
- Aquaculture disease management and microbiota
- Immune Response and Inflammation
- Diet, Metabolism, and Disease
- Patient-Provider Communication in Healthcare
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
Tianjin Medical University Cancer Institute and Hospital
2022-2024
Fujian Agriculture and Forestry University
2022-2023
Second Affiliated Hospital of Dalian Medical University
2020
Dalian Medical University
2020
Shanghai Ocean University
2017
Chinese University of Hong Kong
2014-2016
Hong Kong Jockey Club
2015-2016
Bridge University
2016
Imperial College London
2016
Prince of Wales Hospital
2016
This study identifies interleukin-6 (IL-6)-independent phosphorylation of STAT3 Y705 at the early stage infection with several viruses, including influenza A virus (IAV). Such activation is dependent on retinoic acid-induced gene I/mitochondrial antiviral-signaling protein/spleen tyrosine kinase (RIG-I/MAVS/Syk) axis and critical for antiviral immunity. We generate STAT3Y705F/+ knockin mice that display a remarkably suppressed response to IAV infection, as evidenced by impaired expression...
Meta-analysis (MA) of randomised trials is considered to be one the best approaches for summarising high-quality evidence on efficacy and safety treatments. However, methodological flaws in MAs can reduce validity conclusions, subsequently impairing quality decision making. To assess COPD A cross-sectional study trials. published during 2000–2013 were sampled from Cochrane Database Systematic Reviews Abstracts Effect. Methodological was assessed using validated AMSTAR (Assessing Quality...
<h3>Background:</h3> The effectiveness of acupuncture for managing carpal tunnel syndrome is uncertain, particularly in patients already receiving conventional treatments (e.g., splinting). We aimed to assess the effects electroacupuncture combined with splinting. <h3>Methods:</h3> conducted a randomized parallel-group assessor-blinded 2-arm trial on clinically diagnosed primary syndrome. treatment group was offered 13 sessions over 17 weeks. and control groups both received continuous...
Whereas cysteine dioxygenase 1 (CDO1) expression is lost due to its hypermethylated promoter across a range of cancer types including gastric (GC), functions and molecular underpinnings remain largely unknown. Here we demonstrate that reduced CDO1 indicative unfavorable prognosis in patients with GC. overexpression GC cells markedly inhibits cellular proliferation vitro vivo. Mechanistically, exerts this cytostatic effect via increasing oxidative stress thus activating integrated response...
The contributions of aberrantly expressed metabolic enzymes to gastric cancer (GC) initiation and progression have been widely appreciated in recent years. Acetyl-CoA acetyltransferase 2 (ACAT2) is one member the acetyl- CoA thiolase family. Previous studies demonstrated that ACAT2 either promotes or suppresses tumor different conditions. However, function mechanisms GC remain unknown. We found expression this enzyme was significantly increased tissues compared with normal counterparts,...
In China, Community Health Centers (CHCs) are major providers of primary care services, but their potential in empowering patients' self-management capacity has not been assessed. This study aims to describe self-care practice patterns amongst CHC attendees urban China. this cross-sectional quantitative study, 3360 patients from 6 cities within the Pearl Delta Region were sampled using multistage cluster sampling. Thirty-seven per cent had used with over-the-counter Chinese herbal medicines...
Saprolegniasis, caused by Saprolegnia infection, is one of the most common diseases in freshwater fish. Our study aimed to determine epidemiological characteristics saprolegniasis Chinese regions high incidence. were isolated and identified morphological molecular methods targeting internal transcribed spacer (ITS) ribosomal DNA (rDNA) building neighbor-joining (NJ) maximum parsimony (MP) phylogenetic trees. The ITS sequences eight strains compared with GenBank all fell into three clades:...
STAT2 is an important transcription factor activated by interferons (IFNs) upon viral infection and plays a key role in antiviral responses. Interestingly, here we found that phosphorylation of could be induced several viruses at early stage, including influenza A virus (IAV), such initial activation was independent type I IFNs JAK kinases. Furthermore, it observed the during mainly regulated RIG-I/MAVS-dependent pathway. Disruption Tyr690 restrained response, as silencing or blocking Y690...
Abstract Chinese medicine (CM) is major form of traditional and complementary used by populations. Evaluation on patients’ experience CM service essential for improving quality. This cross sectional study aims (i) to assess how clinics with different administrative model differ in terms quality from perspective; (ii) investigate varies demographic health characteristics. Five hundred sixteen patients were sampled charity semi-public Hong Kong invited their using the Primary Care Assessment...
This study aims to examine the level of empathy perceived by patients receiving care from herbalists, acupuncturists and massage therapists investigate factors that influence levels empathy. Participants who were 18 years or above; able provide written informed consent; read write in Chinese without assistance included. A total 514 participants sampled charity semipublic medicine (CM) clinics Hong Kong recruited assess during various length consultations (1–20 minutes) Consultation...
The mortality rate of lung cancer meningeal metastasis is extremely high. Circulating tumor DNA (ctDNA) has been confirmed to be contain the genomic alterations present in tumors and used monitor progression response treatments. Due presence blood-brain barrier other factors, peripheral blood ctDNA cannot reflect information brain lesions for patients with metastases. However, cerebrospinal fluid as a test sample can better genetic status intracranial guide clinical targeted treatment...
trimoxazole over 3d and 4d co-trimoxazole placebo as conventional therapy. Corresponding dummyplacebos in both groups. Patients of sexes 18–75y ambulatory multicenter setting. Primary outcome: responder rates, expressed by reduction for concentrations bacteria from >105CFU/mL to <103C FU/mL. Secondary change specific complaints symptom score, duration freedom symptoms, safety. Statistical hypothesis noninferiority. Results: 96 patients (90.6%women, median age 38.5y) were randomized...