A5048052469- interferon and immune responses
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Viral Infections and Vectors
- Bacterial biofilms and quorum sensing
- Mosquito-borne diseases and control
- Coccidia and coccidiosis research
- Clostridium difficile and Clostridium perfringens research
- Insect Utilization and Effects
- Animal Nutrition and Physiology
- Vector-Borne Animal Diseases
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Antimicrobial Resistance in Staphylococcus
- Viral Infections and Immunology Research
- Environmental DNA in Biodiversity Studies
- Gut microbiota and health
- Insect symbiosis and bacterial influences
- Poxvirus research and outbreaks
- Microbial infections and disease research
- Autophagy in Disease and Therapy
- Immune responses and vaccinations
- Cardiac Health and Mental Health
Huaqiao University
2023-2024
Shantou University
2022-2023
University of Agriculture Faisalabad
2019-2023
Shantou University Medical College
2022-2023
Fujian Agriculture and Forestry University
2015-2020
Swedish University of Agricultural Sciences
2012-2013
Newcastle disease (ND) is one of the most deadly diseases poultry around globe. The endemic in Pakistan and recurrent outbreaks are being reported regularly wild captive, rural commercial flocks. Though, efforts have been made to characterize causative agent some parts country, genetic nature strains circulating throughout currently lacking. To ascertain genetics NDV, 452 blood samples were collected from 113 flocks, originating all provinces Pakistan, showing high mortality (30–80%)....
Avian Tembusu virus (ATMUV) is a newly emerged flavivirus that belongs to the Ntaya group. ATMUV highly pathogenic causing significant economic loss Chinese poultry industry. However, little known about role of host innate immune mechanism in defending against infection. In this study, we found infection significantly up-regulated expression type I and III interferons (IFN) some critical IFN-stimulated genes (ISG) vivo vitro. This response was induced by genomic RNA ATMUV. Furthermore,...
Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) is a host factor that can repress translation and promote degradation of specific viral mRNAs. In this study, we found expression ZC3HAV1 was significantly induced by infection with influenza A virus (IAV) Sendai (Sev). It shown deficiency IFNAR resulted in dramatic decrease the virus-induced ZC3HAV1. Furthermore, transfection poly(I:C) treatment interferon β (IFN-β) expression. Interference endogenous enhanced replication impairing...
Coccidiosis is a challenging disease of wild and domestic rabbits both, caused by Eimeria thereby leads enormous economic losses at rabbit farms. The present study carried out to survey the prevalence intensity coccidial infection among in Sichuan Province, southwest China. A total 110 faecal samples were collected from 11 farms situated eight main rearing administrative regions. Oocysts purified, sporulated identified according morphological features. overall was 56.4 % (62/110), with 64...
Avian Tembusu virus (ATMUV) is a highly pathogenic flavivirus that causes significant economic losses to the Chinese poultry industry. Our previous experiments demonstrated ATMUV infection effectively triggered host innate immune response through MDA5 and TLR3-dependent signaling pathways. However, little information available on role of interferon-stimulated genes (ISGs) in defending against infection. In this study, we found induced robust expression type I III interferon (IFNs) duck...
Activation of Toll-like receptor (TLR) 4 plays important roles in the influenzaA virus (IAV) infection. To explore TLR4 inhibitors, 161 traditional Chinese medicines (TCMs) were screened. Further, we screened out Ixeris sonchifolia Hance, and its active compound, Apigetrin (apigenin-7-O-glucoside). Antiviral activity was determined by plaque assay. We also further investigated influence on immune signaling pathways including TLRs, MAPK, NF-κB autophagy pathways. The in-vitro results showed...
We report the complete genome sequence of avian paramyxovirus 1 (APMV-1) isolated from an acute and highly contagious outbreak in pheasants (Pucrasia macrolopha) Lahore, Pakistan. Biological serological characterization showed a velogenic strain APMV-1, which was further confirmed by analysis cleavage site fusion protein. Complete sequencing phylogenetic indicated that this isolate belonged to genotype VII, specifically subgenotype VIIa, clustered closely with isolates characterized...
Classical swine fever virus (CSFV) commonly infects the lymphatic tissues and immune cells of pigs could cause a lethal disease in animals. The process release cytokines like type III interferons (IFNs) is one important responses host innate immunity to viral infection. However, little information available about IFN response CSFV In this study, we investigated expression IFNs including interleukin-28B (IL-28B) IL-29 PK-15 following We found that infection with was able induce IL-28B cells,...