A5015876938- Virology and Viral Diseases
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Virus-based gene therapy research
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Immune Response and Inflammation
- Viral Infections and Immunology Research
- Plant Virus Research Studies
- Microbial infections and disease research
- Herpesvirus Infections and Treatments
- RNA modifications and cancer
- Poxvirus research and outbreaks
- Nigella sativa pharmacological applications
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Politics and Conflicts in Afghanistan, Pakistan, and Middle East
- Cytokine Signaling Pathways and Interactions
Lancaster University
2018-2025
University of Science and Technology Beijing
2025
Furness College
2018-2024
Gomal University
2023
École Supérieure du Bois
2021
Pir Mehr Ali Shah Arid Agriculture University
2014-2020
The Pirbright Institute
2013-2018
Lancaster City Council
2018
Jinnah University for Women
2018
Oniris
2016-2017
Sodium-dependent transport into astrocytes is critical for maintaining the extracellular concentrations of glutamate below toxic levels in central nervous system. In this study, expression glial transporters GLT-1 and GLAST was studied primary cultures derived from cortical tissue. astrocytes, protein were approximately one half those observed tissue, but present at very low compared with Maintenance these medium supplemented dibutyryl-cAMP (dbcAMP) caused a dramatic change cell morphology,...
ABSTRACT Many viruses trigger the type I interferon (IFN) pathway upon infection, resulting in transcription of hundreds interferon-stimulated genes (ISGs), which define antiviral state host. Classical swine fever virus (CSFV) is causative agent classical (CSF), a highly contagious viral disease endangering pig industry many countries. However, anti-CSFV ISGs are poorly documented. Here we screened 20 that commonly induced by IFNs against CSFV lentivirus-delivered cell lines, identification...
Coronaviruses demonstrate great potential for interspecies transmission, including zoonotic outbreaks. Although bovine coronavirus (BCoV) strains are frequently circulating in cattle farms worldwide, causing both enteric and respiratory disease, little is known about their genomic evolution. We sequenced analysed the full-length spike (S) protein gene of 33 BCoV from dairy feedlot collected during outbreaks that occurred 2002 to 2010 Sweden Denmark. Amino acid identities were >97 % this...
Newcastle disease virus (NDV) causes severe and economically important in poultry around the globe. None of NDV strains Pakistan have been completely characterized role rural harbouring is unclear. Since they a very for long-term circulation virus, samples were collected from apparently healthy backyard (BYP) flocks. These biologically analyzed using mean death time (MDT) intracerebral pathogenicity index (ICPI), whereas genotypically by real-time PCRs coupled with sequencing complete...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). The authors retract the above paper due to: 1) conflict of interest among authors; and 2) addition coauthor Dr. Muhammad Younus without his knowledge or permission. apologize for these two grave mistakes.
Until vaccines and effective therapeutics become available, the practical solution to transit safely out of current coronavirus disease 19 (CoVID-19) lockdown may include implementation an testing, tracing tracking system. However, this requires a reliable clinically validated diagnostic platform for sensitive specific identification SARS-CoV-2. Here, we report on development de novo, high-resolution comparative genomics guided reverse-transcribed loop-mediated isothermal amplification...
In the last 5 years, frequent outbreaks of infectious bronchitis virus (IBV) are observed in both broiler and layer chicken flocks Kingdom Saudi Arabia (KSA) spite extensive usage vaccines. The IBV is a widespread avian coronavirus affecting vaccinated unvaccinated attributed to significant economic losses, around globe. present study, 58 (
Peste des Petits Ruminants (PPR) is an important viral disease of small ruminants and endemic in Pakistan. In the following study, samples from two outbreaks PPR goats have been subjected to laboratory investigations. The virus (PPRV) genome was detected using both conventional real-time PCR. Genetic characterization local PPRV field isolates conducted by sequencing 322 bp fusion (F) gene 255 nucleoprotein (N) gene. phylogenetic tree based on F clustered into lineage 4 along with other Asian...
Newcastle disease (ND) is one of the most deadly diseases poultry around globe. The endemic in Pakistan and recurrent outbreaks are being reported regularly wild captive, rural commercial flocks. Though, efforts have been made to characterize causative agent some parts country, genetic nature strains circulating throughout currently lacking. To ascertain genetics NDV, 452 blood samples were collected from 113 flocks, originating all provinces Pakistan, showing high mortality (30–80%)....
The capsid (C) protein of the Flaviviridae family members is involved in nucleocapsid formation and virion assembly. However, influence C protein-interacting partners on outcome pestivirus infections poorly defined. In this study, hemoglobin subunit beta (HB) was identified as a protein-binding by glutathione S-transferase pulldown subsequent mass spectrometry analysis PK-15 cells, which are permissive cells for classical swine fever virus (CSFV). Coimmunoprecipitation confocal microscopy...