A5071272526- Prion Diseases and Protein Misfolding
- Climate variability and models
- Neurological diseases and metabolism
- Trace Elements in Health
- Meteorological Phenomena and Simulations
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- interferon and immune responses
- Alzheimer's disease research and treatments
- Virus-based gene therapy research
- RNA regulation and disease
- Urban Heat Island Mitigation
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacteriophages and microbial interactions
- Atmospheric chemistry and aerosols
- Atmospheric aerosols and clouds
- Animal Virus Infections Studies
- Virology and Viral Diseases
- Animal Genetics and Reproduction
- Atmospheric and Environmental Gas Dynamics
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Oceanographic and Atmospheric Processes
- Environmental remediation with nanomaterials
China Agricultural University
2016-2025
Dalian University of Technology
2025
Ministry of Agriculture and Rural Affairs
2022-2025
Institute of Atmospheric Physics
2016-2025
Chinese Academy of Sciences
2016-2025
Chambroad Chemical Industry Research Institute (China)
2022-2025
Kunming University of Science and Technology
2025
Zhejiang University of Technology
2010-2024
Anhui Medical University
2010-2024
Boxing People's Hospital
2024
Changes in terrestrial near-surface wind speed (SWS) are induced by a combination of anthropogenic activities and natural climate changes. Thus, the study long-term changes SWS their causes is very important for recognizing effects these processes. Although slowdown has been analyzed previous studies, to best knowledge, no overall comparison or detailed examination this research performed. Similarly, decreases directions future have not discussed depth. Therefore, we series studies reporting...
Abstract Prion diseases are a group of fatal neurodegenerative disorders characterized by the abnormal folding cellular prion proteins into pathogenic forms. The development these is intricately linked to oxidative stress and mitochondrial dysfunction. Irisin, an endogenous myokine, has demonstrated considerable neuroprotective potential due its antioxidative properties. However, protective effects irisin against have yet be clarified. Our findings indicate that treatment with exogenous can...
Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein, spongiform changes in brain, and brain inflammation as a result wide-spread activation microglia. Autophagy is highly conserved catabolic process for clearance cytoplasmic components, including protein aggregates damaged organelles; this also eliminates pathological PrPSc it accumulates during infection. The NALP3 inflammasome multiprotein complex that component innate immune system...
Prion diseases are neurodegenerative disorders characterized by the accumulation of an abnormal disease-associated prion protein, PrPSc. In prion-infected brains, activated microglia often present in vicinity PrPSc aggregates, and microglial activation is thought to play a key role pathogenesis diseases. Although interleukin (IL)-1β release prion-induced has been widely reported, mechanism which primed become secrete IL-1β not yet elucidated. this study, we investigated NACHT, LRR PYD...
Perfluorochemicals (PFCs) are emerging pollutants of increasing public health and environmental concern due to their worldwide distribution, persistence, bioaccumulation potential. Activated carbon adsorption is an effective method remove PFCs from water. Herein, we report on the sorption four PFCs: perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorobutane (PFBS), perfluorobutanoate (PFBA), deionized water (MQ) landfill groundwater (GW) by granular activated (GAC) in...
The long-term decrease of surface wind speed (SWS) has been revealed by previous studies in China recent decades, but the reasons for SWS remain uncertain. In this paper, we evaluated effects land use and cover change (LUCC) on during 1980–2011 over Eastern Plain (ECP) region using a combined method statistical downscaling observation minus reanalysis data, which was used to improve climate prediction general circulation models evaluate influence LUCC change. To exclude potential...
Abstract Horizontal visibility and water vapor pressure data from 483 stations in China 1960 to 2009 were used inverse aerosol optical depth (AOD) using a new series of parameters, which revised for each station the polybasic nonlinear regression method based on monthly Multiangle Imaging Spectroradiometer (MISR) AOD during 2001–2005. Monthly retrievals 2006 parameters compared with MISR same period. retrieved can capture extreme values better than inversion result original root‐mean‐square...
Abstract Prion diseases caused by the cellular prion protein (PrP C ) conversion into a misfolded isoform Sc are associated with multiple mitochondrial damages. We previously reported dynamic abnormalities and cell death in via modulation of variety factors. Optic atrophy 1 (OPA1) is one factors that control fusion, DNA (mtDNA) maintenance, bioenergetics, cristae integrity. In this study, we observed downregulation OPA1 disease models vitro vivo, mitochondria structure damage dysfunction,...
Abstract A recovery of near-surface wind speed (SWS) in the last decade has been reported over China; nevertheless, contributions large-scale ocean-atmosphere circulations (LOACs) to SWS changes are rarely investigated. In this study, turning point (TP) terrestrial stilling was validated eastern China for 1979–2017. Furthermore, a forward stepwise regression algorithm used assess contribution LOACs changes. The results revealed that TP reversal occurred approximately 2011 during study...
Abstract A persistent accumulation of damaged mitochondria is part prion disease pathogenesis. Normally, are cleared via a major pathway that involves the E3 ubiquitin ligase parkin and PTEN-induced kinase 1 (PINK1) together initiate mitophagy, recognize eliminate mitochondria. However, precise mechanisms underlying mitophagy in remain largely unknown. Using cell models, we observed PINK1-parkin-mediated deficiency which depletion aggravated blocked mitochondrial colocalization with...
Abstract Near‐surface wind speed (NSWS) over China shows multiple time‐scale changes at a centennial scale, but the contributions of internal variability (IV), anthropogenic forcing (ANT), and natural (NAT) to those remain unknown. This study investigated IV, ANT, NAT NSWS scale. Results show that were attributed mainly IV. IV not only modulated interannual in also determined interdecadal transition NSWS. The relative decadal exceeded 75.0%. ANT contributed particularly long‐term reduction...
IgG was traditionally thought to neutralize virions by blocking their attachment or penetration into mucosal epithelial cells, a common site of exposure viruses. However, we describe an intracellular neutralizing action for influenza hemagglutinin-specific monoclonal antibody, Y8-10C2 (Y8), which has activity only at acidic pH. When Y8 applied the basolateral surface Madin–Darby canine kidney cells expressing rat neonatal Fc receptor (FcRn), it significantly reduced viral replication...
Mycobacterium bovis, the causative agent of bovine tuberculosis, infects host macrophages and triggers production proinflammatory cytokine interleukin 1β (IL-1β). The mechanism by which become activated secrete IL-1β in tuberculosis has not yet been elucidated.In this study, we investigated role absence melanoma 2 (AIM2) inflammasome release from infected with pathogenic M. bovis strain.We found that AIM2 activation is involved primary immortalized mouse macrophage upon infection; process...