A5100364534- Statistical Methods and Inference
- Advanced Causal Inference Techniques
- Statistical Methods and Bayesian Inference
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Statistical Methods in Clinical Trials
- Animal Behavior and Welfare Studies
- Effects of Environmental Stressors on Livestock
- Genetic and phenotypic traits in livestock
- Aquaculture disease management and microbiota
- Prion Diseases and Protein Misfolding
- Aquaculture Nutrition and Growth
- Bayesian Methods and Mixture Models
- Carbon Nanotubes in Composites
- Muscle metabolism and nutrition
- Graphene research and applications
- E-commerce and Technology Innovations
- Public-Private Partnership Projects
- Scheduling and Optimization Algorithms
- Health Systems, Economic Evaluations, Quality of Life
- Neuroinflammation and Neurodegeneration Mechanisms
- Agriculture Sustainability and Environmental Impact
- Ruminant Nutrition and Digestive Physiology
- Cell Image Analysis Techniques
- Diet and metabolism studies
Ministry of Agriculture and Rural Affairs
2021-2025
China Agricultural University
2013-2025
Chinese Academy of Fishery Sciences
2023-2025
University of Michigan
2014-2024
Peking University
2010-2023
Feed Research Institute
2022-2023
Shanghai Ocean University
2023
Peking University International Hospital
2020-2022
University of South Carolina
2020
Tsinghua University
2020
Four hemicyanine derivatives, (E)-N-(3-sulfopropyl-4-[2-(4-dimethylaminophenyl)ethenyl]pyridinium (PS), (E)-N-(3-sulfopropyl-4-[2-(4-dimethylaminophenyl)ethenyl]quinolinium (QS), (E)-N-(3-sulfopropyl-4-[2-(4-N-methyl-N-hexadecylaminophenyl)ethenyl]pyridinium (LPS), and (E)-N-(3-sulfopropyl-4-[2-(4-N-methyl-N-hexadecylaminophenyl)ethenyl]quinolinium (LQS), have been synthesized characterized with regard to their absorption electrochemical properties. Photoelectrochemical experiments show that...
COVID-19 caused rapid mass infection worldwide. Understanding its transmission characteristics, including heterogeneity and the emergence of super spreading events (SSEs) where certain individuals infect large numbers secondary cases, is vital importance for prediction intervention future epidemics. Here, we collected information all infected cases (135 cases) between 21 January 26 February 2020 from official public sources in Tianjin, a metropolis China, grouped them into 43 chains with...
Recent studies have supported the relation between mitochondrial functions and degenerative disorders related to ageing, such as Alzheimer's Parkinson's diseases. Since these exposed need for detailed high-resolution analysis of physical alterations in mitochondria, it is necessary be able perform segmentation 3D reconstruction mitochondria. However, due variety structures, automated mitochondria electron microscopy (EM) images proven a difficult challenging task. This paper puts forward an...
Prion diseases are neurodegenerative disorders characterized by the accumulation of misfolded prion protein, spongiform changes in brain, and brain inflammation as a result wide-spread activation microglia. Autophagy is highly conserved catabolic process for clearance cytoplasmic components, including protein aggregates damaged organelles; this also eliminates pathological PrPSc it accumulates during infection. The NALP3 inflammasome multiprotein complex that component innate immune system...
We present new statistical analyses of data arising from a clinical trial designed to compare two-stage dynamic treatment regimes (DTRs) for advanced prostate cancer. The protocol mandated that patients were be initially randomized among four chemotherapies, and those who responded poorly rerandomized one the remaining candidate therapies. primary aim was DTRs' overall success rates, with defined by occurrence successful responses in each two consecutive courses patient's therapy. Of hundred...
Taking natural coal as a "seed bank" of bacterial strains able to degrade lignin that is with molecular structure similar components, we isolated 393 and 483 from meager lean sample Hancheng coalbed brown Bayannaoer coalbed, respectively, by using different media. Statistical analysis showed isolates were significantly more site-specific than medium-specific. Of the 876 belonging 27 genera in Actinobacteria, Firmicutes, Proteobacteria, 612 positive for degradation function, including 218 35...
The p53 mutation and altered Pten expression are two most common genetic events in Hepatitis B virus (HBV) infection related hepatocellular carcinoma (HCC). To confirm the causative role of somatic HCC development, we established CRISPR/Cas9-mediated gene disruption via hydrodynamic tail vein injection, allowing for vivo targeting simultaneously adult HBV transgenic mice. Here demonstrated that utility this approach resulted macroscopic liver tumors as early 4 months' post injection harbored...
Dynamic treatment regimes (DTRs) are sequences of decision rules, in which may be adapted over time response to the changing course an individual. Motivated by substance use disorder (SUD) study, we propose a tree-based reinforcement learning (T-RL) method directly estimate optimal DTRs multi-stage multi-treatment setting. At each stage, T-RL builds unsupervised tree that handles problem optimization with multiple comparisons, through purity measure constructed augmented inverse probability...
Dynamic treatment regimes (DTRs) are sequential decision rules that focus simultaneously on individualization and adaptation over time. To directly identify the optimal DTR in a multi-stage multi-treatment setting, we propose dynamic statistical learning method, adaptive contrast weighted learning. We develop semiparametric regression-based contrasts with of effect ordering for each patient at stage, simplify problem optimization multiple comparisons to classification can be solved by...
Mitochondrial malfunction is a universal and critical step in the pathogenesis of many neurodegenerative diseases including prion diseases. Dynamin-like protein 1 (DLP1) one key regulators mitochondrial fission. In this study, we investigated role DLP1 fragmentation dysfunction neurons using vitro vivo disease models. Mitochondria became fragmented redistributed from axons to soma, correlated with increased expression murine primary (N2a cells) treated peptide PrP106-126 as well...
Protein releases amino acids faster than starch glucose in digestive tract of pigs fed low-protein (LP) diets. Poor synchronization dietary and supply leads to compromised nitrogen efficiency. Dietary patterns modulation may improve this situation.Growing barrows (29.7 ± 2.0 kg) were randomly allotted into 5 treatments with LP diets consisting different purified starches. Treatments included: waxy corn (W LP), + (C W pea (P LP) LP). In the experiment, growth performance, protein deposition,...
This study was to investigate the in vitro antimicrobial activity of fish protein hydrolysate (FPH) against Vibrio harveyi , V. anguillarum and scophthalmi as well nonspecific immunity, intestinal microbiota, disease resistance turbot. FPH prepared from Pollock. The antibacterial measured by agar diffusion, turbidometric assay, plate count. feeding trial performed effect on turbot after three diets containing a high level meal (FM), soybean (SM), 100 g/kg FPH. Agar diffusion showed clearest...
Bacterial skin infections are common in dogs and often secondary to underlying conditions like allergies or ectoparasite infestations. Untreated primary causes can lead recurrent an increased risk of antimicrobial resistance, including methicillin-resistant Staphylococcus pseudintermedius (MRSP), posing a substantial clinical challenge. Here, we analyzed 896 canine bacterial infection samples collected from the China Agricultural University Veterinary Teaching Hospital between 2018 2022....
Abstract We consider nonparametric regression of a scalar outcome on covariate when the is missing at random (MAR) given and other observed auxiliary variables. propose class augmented inverse probability weighted (AIPW) kernel estimating equations for under MAR. show that AIPW estimators are consistent observed, is, selection probability, either known by design or estimated correctly specified model. In addition, we specific estimator in our employs fitted values from model conditional mean...
Bisphenol A (BPA) is toxic to the reproductive and nervous system, even carcinogenetic in humans animals. However, few studies focused on effects of BPA intestinal tract. Here, we detected BPA-induced injuries mucosa explored a reliable approach counteract effects. C57BL/6J mice were gavage or accompanied with ingestion 4% (w/w) glutamine for 4-wks. In vitro, IEC-6 cells treated 0.4 mmol/L 6 hours mimicking acute injury 0.2 12 followed without inclusion 4 determine cell renewal,...
Remarkable Ag-carbenoid-initiated enone cyclopropanation-hydrolytic fragmentation-competitive 1,2-vs-1,4 addition reaction cascades were uncovered on a range of propargylic esters tethered to cyclohexadienones, leading the highly efficient and stereospecific construction densely functionalized bicyclo[3.3.1]nonanes under mild conditions.
A personalized treatment policy requires defining the optimal for each patient based on their clinical and other characteristics. Here we consider a commonly encountered situation in practice, when analyzing data from observational cohorts, that there are auxiliary variables which affect both outcome, yet these not of primary interest to be included generalizable strategy. Furthermore, is enough prior knowledge effect treatments or importance covariates us explicitly specify dependency...
Prostate cancer patients are closely followed after the initial therapy and salvage treatment may be prescribed to prevent or delay recurrence. The decision is usually made dynamically based on patient's evolving history of disease status other time-dependent clinical covariates. A multi-center prostate observational study has provided us data longitudinal specific antigen (PSA) measurements, time-varying treatment, recurrence time. These enable estimate best dynamic regime while accounting...
Yilun Sunab & Lu Wanga*a Department of Biostatistics, University Michigan, Ann Arbor, MI; b Radiation Oncology, MI