A5101906245- Insect behavior and control techniques
- Insect symbiosis and bacterial influences
- Acupuncture Treatment Research Studies
- Insect Utilization and Effects
- Insect-Plant Interactions and Control
- Insect Resistance and Genetics
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Insect Pest Control Strategies
- Agricultural pest management studies
- Healthcare and Venom Research
- Epigenetics and DNA Methylation
- Autonomous Vehicle Technology and Safety
- COVID-19 Clinical Research Studies
- Nuclear Physics and Applications
- Long-Term Effects of COVID-19
- Entomopathogenic Microorganisms in Pest Control
- Neurobiology and Insect Physiology Research
- Advanced Neural Network Applications
- Insect and Pesticide Research
- CRISPR and Genetic Engineering
- Video Surveillance and Tracking Methods
- Moyamoya disease diagnosis and treatment
- Immune responses and vaccinations
Beijing Tsinghua Chang Gung Hospital
2025
Tsinghua University
2025
Xi’an Children’s Hospital
2025
Jiangxi Academy of Agricultural Sciences
2023-2024
Institute of Plant Protection
2023-2024
University of Manchester
2023
Beijing University of Chinese Medicine
2019-2023
Peking University
2017-2023
Hangzhou Medical College
2023
Zhejiang Provincial People's Hospital
2023
Plants are constantly challenged by a multitude of pathogens and pests, which causes massive yield quality losses annually. A promising approach to reduce such is enhance the immune system plants through genetic engineering. Previous work has shown that laccases (p-diphenol:dioxygen oxidoreductase, EC 1.10.3.2) function as lignin polymerization enzymes. Here we demonstrate transgenic manipulation expression laccase gene GhLac1 in cotton (Gossypium hirsutum) can confer an enhanced defense...
Object detection and tracking play a fundamental role in enabling Cooperative Driving Automation (CDA), which is regarded as the revolutionary solution to addressing safety, mobility, sustainability issues of contemporary transportation systems. Although current computer vision technologies can provide satisfactory object results occlusion-free scenarios, perception performance onboard sensors inevitably limited by range occlusion. Owing flexible location pose for sensor installation,...
RNA interference (RNAi) has been developed as a powerful technique in the research of functional genomics well plant pest control.In this report, double-stranded RNAs (dsRNA) targeting 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) gene, which catalyze rate-limiting enzymatic reaction mevalonate pathway juvenile hormone (JH) synthesis cotton bollworm, was expressed plants via Agrobacterium tumefaciens-mediated transformation.PCR and Sothern analysis revealed integration HMGR gene...
The p53 mutation and altered Pten expression are two most common genetic events in Hepatitis B virus (HBV) infection related hepatocellular carcinoma (HCC). To confirm the causative role of somatic HCC development, we established CRISPR/Cas9-mediated gene disruption via hydrodynamic tail vein injection, allowing for vivo targeting simultaneously adult HBV transgenic mice. Here demonstrated that utility this approach resulted macroscopic liver tumors as early 4 months' post injection harbored...
Abstract Background The gut bacteria of tephritid fruit flies play prominent roles in nutrition, reproduction, maintenance and ecological adaptations the host. Here, we adopted an approach based on direct observation symbiotic or axenic feeding dishes seeded with drops full diet (containing all amino acids) supplemented at similar concentrations to explore effects intestinal foraging decision fitness Bactrocera dorsalis . Results results show that probiotics elicit beneficial enhance female...
Abstract Background Nitrogen is considered the most limiting nutrient element for herbivorous insects. To alleviate nitrogen limitation, insects have evolved various symbiotically mediated strategies that enable them to colonize nitrogen-poor habitats or exploit diets. In frugivorous tephritid larvae developing in fruit pulp under stress, it remains largely unknown how obtained and larval development completed. Results this study, we used metagenomics metatranscriptomics sequencing...
The evolution of feeding habits leads to speciation in insects. Bactrocera true fruit flies display diverse across species. We combine behavioral and functional genomic studies probe the divergence between specialist B. minax generalist dorsalis. find that both vision olfaction contribute their respective host preferences, with a dominant effect over short range. Correspondingly, location-related genes are significantly enriched phototransduction pathway, which long-wavelength rhodopsin...
The under-construction White Neutron Source (WNS) at China Spallation is a facility for accurate measurements of neutron-induced cross section. Seven spectrometers are planned WNS. As the physical objectives each spectrometer different, requirements readout electronics not same. In order to simplify development electronics, this paper presents general method detector signal readout. This has advantages expansibility and flexibility, which makes it adaptable most detectors WNS general-purpose...
Acute leukemia is the most common malignancy in children. While chemotherapy effective, it significantly compromises immune function, leading to a high incidence of infectious complications, such as secondary pneumonia, particularly Mycoplasma pneumonia (MP). The treatment infections pediatric patients faces challenges antibiotic resistance and drug interactions during chemotherapy. This study aims evaluate therapeutic efficacy safety doxycycline treating MP post-chemotherapy, well impact on...
Active perception describes a broad class of techniques that couple planning and systems to move the robot in way give more information about environment. In most robotic systems, is typically independent motion planning. For example, traditional object detection passive: it operates only on images receives. However, we have chance improve results if allow consume signals collect views maximize quality results. this paper, use reinforcement learning (RL) methods control order obtain quality....
Abstract Objective Several members of protocadherins (PCDHs) have been identified as tumor suppressor genes in human carcinogenesis, but little is known about PCDH19. The aim the present study was to assess expression and methylation PCDH19 hepatocellular carcinoma (HCC). Methods RNA‐seq data from Cancer Genome Atlas Database were downloaded used for analyzing HCC patients normal liver tissues. We collected 63 paired nontumor tissues hepatitis B virus‐related patients. detected by real‐time...
Targeted drug delivery could increase the efficacy of chemotherapy, however, a plethora obstacles exist in current targeted designs. In this study, we introduce novel avenue using electro-acupuncture and evaluate its effect on distribution paclitaxel breast cancer mouse model. Our results show that intervention significantly increased intratumoral concentration paclitaxel. The mice acupuncture group showed shorter t max, longer 1/2 higher AUC as compared with paclitaxel-only group. Moreover,...
Triple-negative breast cancer (TNBC) is the most aggressive subtype of without effective targeted drugs. While patients often use acupuncture for relief cancer-induced pain or side effects chemo- radiation therapy, little information known regarding direct electroacupuncture on TNBC tumor and its potential mechanisms. Here, we created a mice model with encircled needling around tumors was given to animals daily 3 weeks at 15-20 Hz (3 min, each time). For sham control, skin punctured depth 5...
Aberrant DNA methylation patterns are involved in the pathogenesis of papillary renal cell carcinoma (pRCC). This study aimed to investigate potential methylation-driven genes as biomarkers determining prognosis pRCC by bioinformatics analysis.DNA and transcriptome profiling data were downloaded from The Cancer Genome Atlas database. Methylation-driven (MDGs) obtained using MethylMix R package. A Cox regression model was used screen for prognosis-related MDGs, a linear risk based on MDG...
Introduction Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the most common genetic small vessel disease caused by variants in NOTCH3 gene. Patients CADASIL experience recurrent strokes, developing into cognitive defect vascular dementia. a late-onset condition, but migraine brain MRI lesions appear patients as early their teens twenties, suggesting an abnormal neurovascular interaction at unit (NVU) where microvessels meet parenchyma....
Gymnosporangium species ( Pucciniaceae , Pucciniales Basidiomycota ) are the causal agents of cedarapple rust diseases, which can lead to significant economic losses apple cultivars. Currently, genus contains 17 described that alternate between spermogonial/aecial stages on Malus and telial Juniperus or Chamaecyparis species, although these have yet receive a modern systematic treatment. Furthermore, prior studies shown does not belong sensu stricto (s.str.), nor is it allied any currently...
The integration of HBV DNA is one the carcinogenic mechanisms HBV. clearance in hepatocyte great significance to cure chronic infection and thereby prevent occurrence HBV-related hepatocellular carcinoma (HCC). However, low throughput traditional methods, such as Alu-PCR, results detecting sensitivity integration. Although second-generation sequencing can obtain a large amount data, but fragments are extremely short, so it cannot fully explore characteristics In this study, we used...
Insects employ various types of gustatory receptors (GRs) to identify nutrient-rich food and avoid toxic substances. The larval system is the critical checkpoint for acceptance or rejection. As a specialist herbivore, larvae Bactrocera minax feed only on unripe citrus fruits. However, how use GRs check adapt secondary metabolites in fruits remains unknown. In this study, we first performed developmental expression profiles showing that most BminGRs genes were highly expressed 1st 2nd instar...
Background: The immune system plays an important role in the development of lung squamous cell carcinoma (LUSC).Therefore, immune-related genes (IRGs) expression may be predictor LUSC prognosis.However, a prognostic model based on IRGs that can systematically assess prognosis patients is still lacking.This study aimed to construct by using IRGs.Methods: Gene data about were obtained from Cancer Genome Atlas (TCGA).Differential analysis and univariate Cox regression performed identify...