<title>Abstract</title> Background Carbapenem-resistant Gram-negative bacteria significantly threaten public health due to limited treatment options and high mortality rates. Understanding the factors influencing their detection resistance rates is crucial for effective interventions. Objective: This study aimed investigate carbapenem of Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii in China identify associations with climate, agriculture, economy,...

Background The concurrent administration of tacrolimus and voriconazole in kidney transplant recipients can lead to drug interactions, potentially resulting severe adverse reactions. This study aimed establish a robust population pharmacokinetic model explore the interaction between greater depth. Methods Tacrolimus blood samples laboratory data were prospectively collected from eligible patients enrolled April 2023 2024, following predefined inclusion exclusion criteria. Using Phoenix...

To evaluate the antimicrobial effect of paeoniflorin against carbapenem-resistant Klebsiella pneumoniae (CRKP).Minimum inhibitory concentration (MIC) CRKP was determined by agar dilution method. Changes in intracellular ATP concentration, pH (pHin), cell membrane potential and integrity were investigated to assess influence on damage. Additionally, alterations structure cells damage within biofilms examined. The results indicated that effective at MIC 1·2 mg ml-1 . Paeoniflorin destroyed...

The significance of long non-coding RNAs (lncRNAs) in mediating oxidative stress cancers has been implicated recently. This study proposed a potential therapeutic target lncRNA growth arrest-specific transcript 5 (GAS5) for melanoma, due to its crucial role and apoptosis melanoma cells by regulating the enhancer zeste homolog 2 (EZH2)-mediated CDKN1C expression.The GAS5 expression pattern was examined tissues cells. correlation GAS5, EZH2, with survival rate patients analyzed. In cell lines,...

Background: Hepatocellular carcinoma (HCC) is one of the most deadly cancer types worldwide, and its incidence high in China. Multiple long non-coding RNAs (lncRNAs) have been recently identified as crucial oncogenic factors or tumor suppressors. In this study, we explored effects LncRNA RHPN1 antisense RNA 1 (RHPN1-AS1) on progression HCC. Method: Expression levels RHPN1-AS1 miR-596 HCC samples were measured by qRT-PCR. The association between pathological indexes expression level was also...

Abstract Background Bacterial drug resistance represents a significant global concern, with vancomycin-resistant Enterococcus faecalis posing particularly grave threat to contemporary healthcare systems. This study aims reveal the reasons for prevalence of VRE in China. Methods collected data from China Antimicrobial Resistance Detection System, Statistical Yearbook, and Meteorological Network. The are meticulously organized subjected both single-factor multi-factor analyses. An accurate...

Background: Patients harboring activating mutations in epidermal growth factor receptors (EGFR) are particularly sensitive to EGFR tyrosine kinase inhibitors (TKIs). However, most patients develop an acquired resistance after a period of about 10 months. This study focuses on the therapeutic effect NVP-BEZ235, dual inhibitor phosphatidylinositol- 3-kinase/mammalian target rapamycin (PI3K/mTOR), gefitinib-resistant non-small cell lung cancer. Methods: H1975 line was validated as model by...

Melanoma is notoriously resistant to current treatments, and less than 25% of metastatic melanoma cases respond existing therapies. Growing evidence has shown that microRNAs (miRNAs) play a vital role in the prognosis melanoma. MiR-517a been implicated many types cancer; however, its expressional features potential biological functions remain unclear. The present study aimed investigate possible effects miR-517a on oxidative stress (OS) cells.miR-517a expression was determined using RT-qPCR....

Triptolide (TP), the primary active component purified from traditional Chinese herbal medicine Tripterygium wilfordii Hook. F (TWHF), has been shown to possess antitumor activity in several types of solid tumors. In present study, we investigated effect TP human endometrial cancer cells (HEC-1B) and elucidated its possible underlying mechanisms. HEC-1B were treated with various doses (10, 20, 40, 80, 160 320 nM), cell viability was assessed by Cell Counting Kit-8 (CCK-8) flow cytometric...

Significant increase in tacrolimus exposure was observed during co-administration with voriconazole, and no population pharmacokinetic model exists for renal transplant recipients receiving voriconazole. To achieve target concentrations, an optimal dosage regimen is required. This study aims to develop individualized dosing parameters through analysis simulate concentrations under different regimens.

The increasing problem of bacterial resistance, particularly with quinolone-resistant Escherichia coli (QnR eco) poses a serious global health issue. We collected data on QnR eco resistance rates and detection frequencies from 2014 to 2021 via the China Antimicrobial Resistance Surveillance System, complemented by meteorological socioeconomic Statistical Yearbook Meteorological Data Service Centre (CMDC). Comprehensive nonparametric testing multivariate regression models were used in...

Background: To investigate the inhibitory effect and underlying mechanism of triptolide on cultured human endometrial carcinoma HEC-1B cells corresponding xenograft. Materials Methods: For in vitro studies, inhibition proliferation cell by was determined MTT assay; cycle apoptosis triptolide-treated untreated were detected flow cytometry. vivo a xenograft tumor model established using cells, then tumor-bearing mice treated with high, medium, low-dose (<TEX>$8{\mu}g$</TEX>,...

<title>Abstract</title> <bold>Background:</bold> Bacterial drug resistance is becoming increasingly serious,This study aims to investigate the relationship between rate of erythromycin-resistant Streptococcus pneumoniae and reasons for epidemic under complex geographical climatic factors in China. <bold>Methods: </bold>Data spanning from 2014 2021, including rates, isolate meteorological variables, demographic statistics, were collected China Antimicrobial Resistance Monitoring System,...

Abstract Background: The current situation of bacterial resistance is severe. This study aimed to investigate the relationship between four Gram-negative bacteria and environment, diet, mortality. Methods: Data for this were sourced from China Antimicrobial Resistance Surveillance System (CARSS). monitoring prev-alence carbapenem-resistant Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae Acinetobacter baumannii in 31provinces (city) over period 2014 2021. Subsequently, a...

<title>Abstract</title> Background and objectives: Sepsis septic shock are critical health emergencies with high morbidity mortality rates, often triggered by infections. The study investigates Polymyxin B-immobilized fiber column hemoperfusion (PMX-HP) as a supplementary therapy, evaluating its efficacy in critically ill patients sepsis or shock, determining the optimal treatment protocol. Methods: This conducted systematic review across multiple databases, including PubMed, EMBASE,...

This study aimed to establish a population pharmacokinetic (PopPK) model using data from 2 clinical trials of zimberelimab, evaluate the pharmacokinetics (PKs) explore feasibility 360 mg once every 3 weeks (Q3W) and 480 4 (Q4W) as alternative dosage regimens, analyze exposure-response relationship efficacy safety zimberelimab for advanced tumors. The PKs were described 2-compartment with time-dependent nonlinear elimination. prediction-corrected visual predictive check was used model's value...