A5101687901- Advanced Optical Sensing Technologies
- Photoacoustic and Ultrasonic Imaging
- Optical Coherence Tomography Applications
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Parasites and Host Interactions
- Histone Deacetylase Inhibitors Research
- Antimicrobial Resistance in Staphylococcus
- Drug-Induced Hepatotoxicity and Protection
- Salivary Gland Tumors Diagnosis and Treatment
- Liver Disease and Transplantation
- Kidney Stones and Urolithiasis Treatments
- Mycobacterium research and diagnosis
- Neuroendocrine Tumor Research Advances
- Parasite Biology and Host Interactions
- Tuberculosis Research and Epidemiology
- Cancer Mechanisms and Therapy
- Pediatric Urology and Nephrology Studies
- SARS-CoV-2 and COVID-19 Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Liver physiology and pathology
- Viral gastroenteritis research and epidemiology
Wenzhou Medical University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
East China Normal University
2023-2025
Harbin Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2025
Southern Medical University
2011-2024
Nanfang Hospital
2016-2024
First People's Hospital of Yunnan Province
2012-2024
Kunming University of Science and Technology
2022-2024
Beijing Tongren Hospital
2023-2024
Perioperative neurocognitive disorders (PND) are the most common postoperative complications with few therapeutic options. Gut microbial dysbiosis is associated neurological diseases; however, mechanisms by which microbiota regulates gastrointestinal and cognitive function incompletely understood.Behavioral testing, MiSeq 16S rRNA gene sequencing, non-target metabolism, intestinal permeability detection, protein assays, immunofluorescence staining were employed to discern impacts of surgery...
Abstract Epoxy asphalt, a thermosetting polymer, is characterized by stable, irreversible internal chemical bonds that prevent recovery and spontaneous micro‐crack healing, unlike conventional asphalt. This study introduces renewable nano‐modifier synthesized via esterification of carboxyl‐functionalized carbon nanotubes (CNTs‐COOH) furfuryl alcohol (FA), termed CNTs‐FA. The successful synthesis CNTs‐FA was confirmed through various microscopic techniques. Integrating into epoxy asphalt...
Compressed ultrafast photography (CUP) has attracted significant attention in the field of optical imaging but is inherently constrained by a trade-off between sequence depth and spatial resolution. To address this limitation, we present novel, to best our knowledge, system called line integral CUP (LI-CUP). LI-CUP utilizes cylindrical lens compress each encoded time-slice frame into line, which then recorded streak camera with narrow slit. This approach transforms temporal compression...
The non-catalytic functions of kinases have provided novel and crucial mechanisms underlying kinase inhibitor resistance, thereby presenting new opportunities for discovery kinase-targeted drugs. Nevertheless, only a very limited modulators targeting been reported. As the first discovered proto-oncogene, non-receptor tyrosine SRC promotes progression hematologic malignancies numerous solid tumors via complex pathways. Several inhibitors were approved treatment malignancies, yet not tumors....
Urolithiasis is a common disease of the urinary tract, global prevalence which increasing year by and which, due to its high rate recurrence complications, represents major burden on quality life patients public health system. As most populous country in world, epidemiology urolithiasis China great importance. However, current systematic epidemiological assessment relatively limited. Therefore, this study used GBD 2021 database systematically assess provide basis for policy formulation. This...
The increasing epidemiological trend of pediatric urolithiasis over the past three decades has brought it to forefront public health attention. An analysis disease burden in Brazil, Russia, India, China, and South Africa (BRICS) countries, which share common characteristics such as large population base limited resources, will provide an important reference for global policy development. Therefore, this study aimed investigate prevalence BRICS countries during 1990-2021, turn more valuable...
Liver fibrosis, a complex process resulting from most chronic liver diseases, remains devoid of effective treatments. An increasing body evidence links fibrosis to the "gut-liver axis", with disruptions in gut microbiota-host balance emerging as critical contributor its progression. Cinnamaldehyde (Cin), natural compound antioxidant, anti-inflammatory, and anticytotoxic properties, has shown potential counteracting hepatic stellate cell (HSC) activation. Additionally, Cin been promote...
We have demonstrated previously that the Myc oncoprotein blocks cancer cell differentiation by forming a novel transcriptional repressor complex with histone deacetylase and inhibiting gene transcription of tissue transglutaminase (TG2). Moreover, induction TG2 transamidase activity is essential for differentiating effects retinoids in cells. Here, we show two structurally distinct protein isoforms, full-length (TG2-L) short form (TG2-S), exert opposing on differentiation. Repression TG2-L...
Liver fibrosis is a major contributor to the morbidity and mortality associated with liver diseases, yet effective treatment options remain limited. Hepatic stellate cells (HSCs) are promising target for hepatic fibrogenesis due their pivotal role in disease progression. Our previous research has demonstrated potential of Dihydrotanshinone I (DHI), lipophilic component derived from natural herb Salvia miltiorrhiza Bunge, treating by inhibiting YAP/TEAD2 interaction HSCs. However, clinical...
Abstract Studies suggest that mangiferin (MAF) has good therapeutic effects on chronic bronchitis and hepatitis. Also, it is one of the antiviral ingredients in Anemarrhena asphodeloides Bunge. However, its effect LPS‐induced inflammation intestinal flora during sepsis remains unclear yet. In present study, LPS‐stimulated RAW264.7 cells mice were used to evaluate efficacy MAF vitro vivo. 16S rDNA sequencing was performed analyze characteristics mice. It been demonstrated (12.5 25 μg/mL)...
Annexin A1 (ANXA1) acts either as a tumor suppressor or an oncogene in different types. Several clinical studies revealed that the expression of ANXA1 is associated with pathologic differentiation grade oral squamous cell carcinoma (OSCC) patients. However, direct function OSCC progression has remained to be fully clarified. The present study was designed investigate role proliferation and invasion vitro. Furthermore, whether involved transforming growth factor β1 (TGFβ1)/epidermal...
Abstract Background Obesity is associated with a wide variety of metabolic disorders that impose significant burdens on patients and society. The “browning” phenomenon in white adipose tissue (WAT) has emerged as promising therapeutic strategy to combat disturbances. However, though the anti-diabetic drug dapagliflozin (DAPA) thought promote “browning,” specific mechanism this was previously unclear. Methods In study, C57BL/6 J male mice were used establish an obesity model by high-fat diet...
Abstract Compressed ultrafast photography (CUP) can capture irreversible or difficult‐to‐repeat dynamic scenes at the imaging speed of more than one billion frames per second, which is obtained by compressive sensing‐based image reconstruction from a compressed 2D through discretization detector pixels. However, an excessively high data compression ratio in CUP severely degrades quality, thereby restricting its ability to observe with complex spatial structures. To address this issue,...
The large drying shrinkage is one of the most serious factors limiting practical application alkali-activated slag concrete (AASC). In this study, based on successful reduction waste cooking oil for paste (AASP), influence stearic acid (saturated fatty acids) and oleic (unsaturated fresh properties (setting time fluidity), physical characteristics (density water absorption), mechanical strengths (flexural strength compressive strength), durability (drying shrinkage, self-shrinkage,...
Background Bowen’s disease (BD) is a slow-growing precancerous skin condition, often concurrent with other diseases, high misdiagnosis rate. Previous studies show that patients BD in different populations have differentiated characteristics. Materials and methods A retrospective study was conducted tertiary hospital Shenzhen, China. Data about demographic information, diagnosis treatment, clinical pathological characteristics, comorbidities of 50 were collected analyzed. Results Clinical...
Abstract Objectives To develop a novel ultrasound scoring system for the major salivary glands in patients with immunoglobulin G4-related sialadenitis (IgG4-RS) and assess its diagnostic value multicentre cohort of Chinese patients. Methods Twenty clinicians (rheumatologists, stomatologists radiologists) participated. The study was conducted four steps: (i) defining ultrasonography (US) elements, (ii) developing US glands, (iii) evaluation inter- intra-reader reliabilities using new system,...
Naoxintong Capsule (NXT), a renowned traditional Chinese medicine (TCM) formulation, has been broadly applied in China for more than 30 years. Over decades, accumulating evidences have proven satisfactory efficacy and safety of NXT treating cardiovascular cerebrovascular diseases (CCVD). Studies conducted unceasingly, while this growing latest knowledge not yet interpreted properly summarized comprehensively. Hence, we systematically review the advancements research, from its chemical...
Hyperspectrally compressed ultrafast photography (HCUP) based on sensing and time- spectrum-to-space mappings can simultaneously realize the temporal spectral imaging of non-repeatable or difficult-to-repeat transient events with a passive manner in single exposure. HCUP possesses an incredibly high frame rate tens trillions frames per second sequence depth several hundred, therefore plays revolutionary role single-shot optical imaging. However, due to ultra-high data compression ratios...