A5101602075- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Semiconductor materials and devices
- Nephrotoxicity and Medicinal Plants
- Metabolomics and Mass Spectrometry Studies
- Cancer Genomics and Diagnostics
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Molecular Biology Techniques and Applications
- Circular RNAs in diseases
- Mast cells and histamine
- Plant-based Medicinal Research
- Cancer, Hypoxia, and Metabolism
- Oral microbiology and periodontitis research
- RNA modifications and cancer
- Plant and animal studies
- Advancements in Semiconductor Devices and Circuit Design
- Silicon Carbide Semiconductor Technologies
- Silicon Nanostructures and Photoluminescence
- Plant and Fungal Species Descriptions
- Cancer-related molecular mechanisms research
- Forensic and Genetic Research
Institute of Semiconductors
2024-2025
Chinese Academy of Sciences
2011-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Sun Yat-sen University
2024
Central South University
2021-2024
China Shenhua Energy (China)
2024
Stomatology Hospital
2023-2024
Simcere Pharmaceutical (China)
2023
Nanchang University
2023
Huazhong Agricultural University
2023
Abstract The silk gland of the domesticated silkworm Bombyx mori , is a remarkable organ that produces vast amounts with exceptional properties. Little known about which cells execute protein synthesis and its precise spatiotemporal control. Here, we use single-cell RNA sequencing to build comprehensive cell atlas gland, consisting 14,972 high-quality representing 10 distinct types, in three early developmental stages. We annotate all types determine their distributions each region gland....
As carriers of biomolecules (proteins, nucleic acids, and lipids) from parent cells, exosomes play a significant role in physiology pathology. In any diseased state, the morphology released remained similar. The contents change depending on disease or its stage; thus, are generally considered as "source biomarkers". Therefore, they promising biomarkers for diagnosis prognosis tumors. natural delivery vehicles, can protect their cargo immune clearance deliver them to other cells through...
A 4H-silicon carbide (SiC) trench gate metal–oxide–semiconductor field-effect transistor (MOSFET) with dual integrated Schottky barrier diodes (SBDs) was characterized using numerical simulations. The advantage of three-dimensional stacked integration is that it allows the proposed structure to obtain an electric field below 0.6 MV/cm in oxide and SBD contacts achieve ~10% lower forward voltage SBDs than planar SBD-integrated MOSFET (PSI-MOS) three p-type-protecting layers (TPL-MOS)....
A growing body of research has revealed the connection metabolism reprogramming and tumor progression, yet how affects inter-patient heterogeneity prognosis in head neck squamous cell carcinoma (HNSCC) still requires further explorations.A cellular hierarchy framework based on metabolic properties discrepancy, METArisk, was introduced to re-analyze composition from bulk transcriptomes 486 patients through deconvolution utilizing single-cell reference profiles 25 primary 8 metastatic HNSCC...
Dendrobium nestor is a famous orchid species in the Orchidaceae family. There diversity of flower colorations species, but knowledge genes involved and molecular mechanism underlying color formation D. less studied. Therefore, we performed transcriptome profiling using Illumina sequencing to facilitate thorough studies purple petal samples collected at three developmental stages, namely—flower bud stage (F), half bloom (H), full (B) nestor. In addition, identified key their biosynthetic...
Background: Yixinshu Capsules (YXSC) are widely used in Chinese medicine for the treatment of cardiovascular diseases. However, therapeutic mechanisms action not well understood. Method: In this study, a metabonomic approach based on integrated UPLC-Q/TOF-MS technique and MALDI-MS was utilized to explore potential metabolic biomarkers that may help increase understanding heart failure (HF) order assess YXSC against HF. Plasma profiles were analyzed by with complementary hydrophilic...
Naoxintong Capsule (NXT), a renowned traditional Chinese medicine (TCM) formulation, has been broadly applied in China for more than 30 years. Over decades, accumulating evidences have proven satisfactory efficacy and safety of NXT treating cardiovascular cerebrovascular diseases (CCVD). Studies conducted unceasingly, while this growing latest knowledge not yet interpreted properly summarized comprehensively. Hence, we systematically review the advancements research, from its chemical...
In this work, a stability-indicating high-performance liquid chromatography (HPLC) method was developed and validated for the simultaneous analysis of ketoconazole (KCZ) beauvericin (BEA) as well their degradation products in combination tablets. KCZ is synthetic broad-spectrum antifungal agent with risk hepatoxicity. However, it found that combined use BEA low dose had not only maintained activity but also significantly reduced liver toxicity. The development started from forced studies...
To improve the treatment of patients with coronary heart disease (CHD), personalized treatments based on potential biomarkers could make a difference. investigate if such be found for CHD inhomogeneous, we combined traditional Chinese medicine diagnosis untargeted and targeted metabolomics analyses. Shi Xu patient subtype groups angina pectoris were identified. Different metabolites including lipids, fatty acids amino further analyzed mapped to disease-related pathways. The long-chain...
Metabolites/impurities (MIs) of penicillin are normally considered to be the main substances inducing immediate hypersensitivity reactions in treatment. Our previous research found that can cause non-allergic (NAHRs) by directly triggering vascular hyperpermeability and exudative inflammation. However, chief culprits underlying mechanisms involved penicillin-induced NAHRs have not yet been fully elucidated. In this study, we used a combination approaches including mouse reaction model,...
There is urgent need to discover effective traditional Chinese medicine(TCM) for treating coronavirus disease 2019(COVID-19). The development of a bioinformatic tool beneficial predict the efficacy TCM against COVID-19. Here we deve-loped prediction platform TCMATCOV anti-coronavirus pneumonia effect TCM, based on interaction network imitating This COVID-19 model was constructed by protein-protein interactions differentially expressed genes in mouse caused SARS-CoV and cytokines specifically...
The difference in pharmacological activities and active components between leaves, barks flowers of Eucommia ulmoides(EU) are still unclear. However, clarifying the differences effects different parts EU is great significance for development products, their corresponding provide basis quality control EU. Based on chemical compositions EU, integrated strategy target prediction analysis compounds was used to investigate followers. "component-target-function" association network constructed...
With the global outbreak of coronavirus disease 2019(COVID-19), screening effective drugs has became emphasis research today; furthermore, Chinese classic prescriptions one directions for drug development. This study analyzed application in diagnosis and treatment schemes based on Diagnosis Treatment Schemes Coronavirus Disease at country, provincial municipal levels, further explored its disrobing effect COVID-19 severe phase network, selected representative core target gene enrichment...