A5061821541- Oral Health Pathology and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Oral and gingival health research
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Oral health in cancer treatment
- Oral microbiology and periodontitis research
- HVDC Systems and Fault Protection
- Cancer Immunotherapy and Biomarkers
- Xenotransplantation and immune response
- Genetic factors in colorectal cancer
- NF-κB Signaling Pathways
- Salivary Gland Disorders and Functions
- Amino Acid Enzymes and Metabolism
- Fibroblast Growth Factor Research
- Cancer, Lipids, and Metabolism
- Mycobacterium research and diagnosis
- Autophagy in Disease and Therapy
- Immune cells in cancer
Sun Yat-sen University
2016-2025
Stomatology Hospital
2010-2024
Hospital of Stomatology, Sun Yat-sen University
2013-2024
The University of Texas MD Anderson Cancer Center
2016-2017
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2011
Although microRNA-155 (miR-155) is known to play an important role in many cancers, its expression and function oral squamous cell carcinoma (OSCC) was not fully understood. Thus, the present study, we investigated of miR-155 also this miR plays OSCC. We used OSCC line (CAL27) paired tumor non-tumor tissue samples from patients with order detect miR-155. Cell proliferation, migration invasion assays were then undertaken determine effect on biological behavior CAL27 cells following transient...
Although obesity has been associated with an increased risk and aggressiveness of many types carcinoma, whether it promotes squamous cell carcinoma remains unclear. To reveal the role in oral (OSCC) initiation development, we used 4NQO-induced OSCC model mice to examine impact dietary on carcinogenesis. The results showed that high-fat diet (HFD)-induced significantly promoted incidence altered local immune microenvironment expansion CD11b+Gr1+ myeloid-derived suppressor cells (MDSCs)....
Abstract For head and neck squamous cell carcinoma (HNSCC), the local invasion distant metastasis represent predominant causes of mortality. Targeted inhibition chemokines their receptors is an ongoing antitumor strategy established on crucial roles in cancer metastasis. Herein, we showed that C-C motif chemokine ligand 2 (CCL2)- receptor 4 (CCR4) signaling, but not CCL2- (CCR2) axis, induces formation vav guanine nucleotide exchange factor (Vav2)- Rac family small GTPase 1 (Rac1) complex to...
Although oxidative stress is closely associated with tumor invasion and metastasis, its' exact role mechanism in the initial stage of oral cancer remain ambiguous. Glutamine uptake mediated by alanine-serine-cysteine transporter 2 (ASCT2) participates glutathione synthesis to resolve stress. Currently, we firstly found that ASCT2 deletion caused mucosa promoted carcinogenesis induced 4-Nitroquinoline-1-oxide (4-NQO) using transgenic mice knockout epithelium. Subsequently, identified an...
Introduction: Aging is associated with significant metabolic alterations that contribute to cellular senescence and age-related functional decline. As individuals age, an increased prevalence of oral diseases a gradual decline in functions are observed. However, the shifts underlying mucosal aging remain unexplored. Methods: We initially conducted histological analyses on tongues from young (4-week-old), adult (4-month-old) old (20-month-old) C57BL/6 mice identify tongue mucosa....
Background: Although the roles of interferon (IFN)‐gamma and interlekin (IL)‐4 in oral lichen planus (OLP) have been described extensively past decades, available results are controversial. Moreover, few studies utilized simultaneous detection cytokines local tissues saliva to determine whether salivary could reflect fact lesions. Methods: IFN‐gamma IL‐4 were determined simultaneously lesions whole unstimulated (WUS) from OLP patients with various clinical forms. Results: In lesions, both...
Chemokine ( CC motif) ligand 18 CCL 18) is involved in remodeling of the tumor microenvironment and plays critical roles oncogenesis, invasiveness, metastasis. We previously investigated overexpression primary oral squamous cell carcinoma OSCC ) tissues its association with advanced clinical stage patients. However, underlying mechanisms this 18‐derived activity remains unidentified. This study showed exogenous increased migration invasion induced epithelial–mesenchymal transition EMT ),...
Although a few studies suggested that the chemokine CCL2 might be involved in development of oral squamous cell carcinoma (OSCC), exact mechanism remains unclear. In this study, we aimed to determine resource lesions and explored potential promotes tumor progression. The study was an effort provide new insights into pathological role OSCC.Specimens OSCC normal mucosa were stained using immunohistochemistry (IHC) assess expression. Enzyme-linked immunosorbent assay (ELISA) used detect...
Abstract Background Alanine‐serine‐cysteine transporter 2 (ASCT2), a major glutamine transporter, is essential for cell growth and tumor development in variety of cancers. However, the clinicopathological significance pathological role ASCT2 OSCC (oral squamous carcinoma) lesions remain unclear. Methods Sections from 89 patients 10 paracancerous tissue controls were stained by immunohistochemistry (IHC) to detect expression ASCT2, glutaminase, Ki‐67. Survival analysis was carried out...
A growing body of research has revealed the connection metabolism reprogramming and tumor progression, yet how affects inter-patient heterogeneity prognosis in head neck squamous cell carcinoma (HNSCC) still requires further explorations.A cellular hierarchy framework based on metabolic properties discrepancy, METArisk, was introduced to re-analyze composition from bulk transcriptomes 486 patients through deconvolution utilizing single-cell reference profiles 25 primary 8 metastatic HNSCC...
The molecular biological properties of oral lichen planus (OLP) are largely unknown. aim this study was to identify the genes responsible for its pathogenesis at genome scale using DNA microarray technology.The RNA samples extracted from specimens nine OLP patients and controls were analyzed with Affymetrix GeneChip. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) analysis applied confirm GeneChip results.A total 985 differentially expressed (629 up-regulated 356...
Objective . The chemokine receptor CXCR4 and its ligand CXCL12 have been suggested to play important roles in the initiation or progression of cancers. goal present study was investigate alterations CXCL12/CXCR4 oral premalignant lesions squamous cell carcinoma (OSCC). Methods In 13 normal epithelia, 24 dysplastic leukoplakia (OLK), 40 OSCC specimens, expressions were evaluated by immunohistochemistry. Results expressed 37.5% OLK 60% OSCC. detected 50% 62.5% OLK, positive ratio showed no...
Unlike normal cells, cancer cells are recently identified to rely on aerobic glycolysis for energy production called the Warburg effect. Several attempts being made target this metabolic reprogramming pathway in treating cancers; however, successful rate is very limited. In study, we investigated functional roles of fatty acid oxidation key enzyme carnitine palmitoyl transferase 1a (CPT-1a), during programming pancreatic ductal adenocarcinoma (PDAC) induced by glucose deprivation. Knockdown...
Protein arginine methyltransferase 5 (PRMT5) is an important type II that can play roles in cancers a highly tissue-specific manner, but its role the carcinogenesis and metastasis of head neck squamous cell carcinoma (HNSCC) remains unclear. Here, we detected PRMT5 expression HNSCC tissues performed series vivo vitro assays to investigate function mechanism HNSCC. We found was overexpressed dysplastic cancer tissues, associated with lymph node worse patient survival. knockdown repressed...
Oral squamous cell carcinoma (OSCC) is the 11th most prevalent tumor worldwide. Despite advantages of therapeutic approaches, 5-year survival rate patients with OSCC less than 50%. It urgent to elucidate mechanisms underlying progression for developing novel treatment strategies. Our recent study has revealed that Keratin 4 (KRT4) suppresses development, which downregulated in OSCC. Nevertheless, mechanism downregulating KRT4 remains unknown. In this study, touchdown PCR was utilized detect...