A5060432160- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- RNA regulation and disease
- RNA Interference and Gene Delivery
- S100 Proteins and Annexins
- Oral microbiology and periodontitis research
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Lipid metabolism and biosynthesis
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Oral Health Pathology and Treatment
- Ear and Head Tumors
- Fibroblast Growth Factor Research
- Diet and metabolism studies
- Photodynamic Therapy Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Metabolism, Diabetes, and Cancer
- Dietary Effects on Health
- Peroxisome Proliferator-Activated Receptors
- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
Hospital of Stomatology, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Chinese Academy of Sciences
2022-2024
State Key Laboratory of Stem Cell and Reproductive Biology
2024
Stomatology Hospital
2018-2024
Institute of Zoology
2022-2024
Fudan University
2024
Abstract Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia (SCC) stages. Recently, increasing evidence has suggested that tumor microenvironment (TME) an integral part of malignant transformation. Exploring certain key node genes in TME for future intervention to interrupt oral carcinogenesis was primary goal this research. To achieve goal, systems biology approaches were first applied epithelia fibroblasts collected at...
Abstract Aging has a profound impact on the gingiva and significantly increases its susceptibility to periodontitis, worldwide prevalent inflammatory disease. However, systematic characterization comprehensive understanding of regulatory mechanism underlying gingival aging is still lacking. Here, we systematically dissected phenotypic characteristics during in primates constructed first single-nucleus transcriptomic landscape aging, by which panel cell type-specific signatures were...
Abstract CDK4/6 inhibitors show promising antitumor activity in a variety of solid tumors; however, their role head and neck squamous cell carcinoma (HNSCC) requires further investigation. The senescence-associated secretory phenotype (SASP) induced by has dual effects on cancer treatment. need to address the SASP is serious challenge clinical application inhibitors. We investigated whether metformin can act as senostatic drug modulate enhance anticancer efficacy HNSCC. In this study,...
Although obesity has been associated with an increased risk and aggressiveness of many types carcinoma, whether it promotes squamous cell carcinoma remains unclear. To reveal the role in oral (OSCC) initiation development, we used 4NQO-induced OSCC model mice to examine impact dietary on carcinogenesis. The results showed that high-fat diet (HFD)-induced significantly promoted incidence altered local immune microenvironment expansion CD11b+Gr1+ myeloid-derived suppressor cells (MDSCs)....
Abstract Emerging evidence shows that lipid metabolic reprogramming plays a vital role in tumor metastasis. The effect and mechanism of fatty acids droplets (LDs), the core products metabolism, on metastasis oral squamous cell carcinoma (OSCC), need further exploration. In this study, influence palmitic acid (PA) oleic (OA) migration invasion ability OSCC cells was determined by vitro experiments. Genetic manipulation PLIN2 performed to explore its accumulation LDs Possible mechanisms these...
Abstract Background Alanine‐serine‐cysteine transporter 2 (ASCT2), a major glutamine transporter, is essential for cell growth and tumor development in variety of cancers. However, the clinicopathological significance pathological role ASCT2 OSCC (oral squamous carcinoma) lesions remain unclear. Methods Sections from 89 patients 10 paracancerous tissue controls were stained by immunohistochemistry (IHC) to detect expression ASCT2, glutaminase, Ki‐67. Survival analysis was carried out...
Abstract Messenger RNA (mRNA)-based transient expression of CAR shows optimal safety profiles and provides promising opportunities to address existing challenges viral vector-based CAR-T therapies meet emerging medical needs in noncancerous indications. However, linear mRNAs are intrinsically unstable thus just achieve compromised efficacy. Here, we engineered a permuted intron exon (PIE) platform synthesize scarless circular mRNA (cmRNA) for potent long-lasting cmRNA significantly increased...
Tacrolimus (TAC, FK506) is a major calcineurin inhibitor and has been commonly used in treatments of patients with organ transplants immune diseases. Moreover, tacrolimus recommended by the treatment guidelines for oral potentially malignant disorders (OPMDs) such as lichen planus (OLP). However, whether increases risk cancer remains controversial. We observed that 4-Nitroquinoline N-oxide (4NQO)-induced carcinogenesis model, was associated significantly lower ratio formation (52.94% vs....
Abstract Radiotherapy for nasopharyngeal carcinoma has been reported to cause second primary oral squamous cell (s‐OSCC). The prognosis and pathologic characteristic of s‐OSCC are largely unknown. Bmi1 was associated with the repair radiation‐induced DNA damage, suggesting its possible involvement in process s‐OSCC. Herein, we compared between OSCC (p‐OSCC) explored development. In this retrospective study, p‐OSCC patients were matched by propensity scores. Their outcomes univariate...
Obesity is a leading cause of multiple cancers, but whether it promotes esophageal squamous cell carcinoma (ESCC) and its underlying cancer-promoting mechanism remains unclear. To evaluate the effect high-fat diet (HFD) on ESCC explore role myeloid-derived suppressor cells (MDSCs) in HFD-induced ESCC, C57BL/6J mice were treated with 4-nitroquinoline 1-oxide (4NQO) to induce randomly assigned an HFD or normal-fat diet. An anti-Gr1 monoclonal antibody was used deplete MDSCs context...
The oral cavity is a complex physiological community encompassing wide range of microorganisms. Dysbiosis microbiota can lead to various infectious diseases, such as periodontitis and tooth decay, even affect systemic health, including brain aging neurodegenerative diseases. Recent studies have highlighted how microbes might be involved in neurodegeneration, indicating potential avenues for intervention strategies. In this review, we summarize clinical evidence demonstrating link between...
Abstract Objectives Radiation injury is common after radiotherapy for head and neck cancer. Radiotherapy can reshape the immune microenvironment cause immunosuppression, including dysregulation of checkpoints (ICs). However, relationship between oral ICs expression radiation development second primary tumors unclear. Methods Clinical specimens squamous cell carcinoma (s‐OSCC) OSCC (p‐OSCC) were collected. The prognostic value PD‐1, VISTA, TIM‐3 analyzed using immunohistochemistry. To further...
The majority of cases oral squamous cell carcinoma (OSCC) develop from potentially malignant disorders, which have been confirmed to be involved in chronic oxidative stimulation. However, no effective treatment approaches used prevent the development dysplasia into cancerous lesions thus far. In present study, a well-established OSCC model was detect proteomics profiles at different stages during transformation. Of 15 proteins that were found upregulated both and stages, stress-associated...
This study aims to clarify whether blood lipid profiles are indicators of prognosis in patients with head and neck squamous cell carcinoma (HNSCC).
Metabolic reprogramming and immunologic suppression are two critical characteristics promoting the progression of head neck squamous cell carcinoma (HNSCC). The integrative analysis all metabolism-related genes (MRGs) in HNSCC is lacking interaction between metabolism immune also requires more exploration to uncover potential mechanisms. Therefore, this study was designed establish a prognostic signature based on MRGs HNSCC. Genes samples were available from TCGA GEO databases while...