A5100399436- T-cell and B-cell Immunology
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Vasculitis and related conditions
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Rheumatoid Arthritis Research and Therapies
- Single-cell and spatial transcriptomics
- Pharmacological Effects of Natural Compounds
- IL-33, ST2, and ILC Pathways
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Poxvirus research and outbreaks
- Natural Compounds in Disease Treatment
- MicroRNA in disease regulation
- Biomarkers in Disease Mechanisms
- Chronic Lymphocytic Leukemia Research
- vaccines and immunoinformatics approaches
- Mining and Resource Management
- Selenium in Biological Systems
- Phagocytosis and Immune Regulation
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Hainan General Hospital
2024
Tufts University
2024
State Key Laboratory of Stem Cell and Reproductive Biology
2024
University of Chinese Academy of Sciences
2024
Institute of Zoology
2024
Chinese Academy of Sciences
2024
State Key Laboratory of Membrane Biology
2024
Weifang University
2024
Increasing evidence indicates that microRNAs (miRNAs) play a critical role in the pathogenesis of inflammatory diseases. The aim study was to investigate expression pattern and function miRNAs CD4+ T cells from patients with rheumatoid arthritis (RA).The profile synovial fluid (SF) peripheral blood 33 RA determined by microarray assay validated qRT-PCR analysis. correlation between altered cytokine levels linear regression miR-146a overexpression regulating cell apoptosis evaluated flow...
In patients with systemic lupus erythematosus (SLE), immune tolerance breakdown leads to autoantibody production and immune-complex glomerulonephritis. This study aimed identify pathogenic plasma cells (PC) in the development of nephritis.PC subsets peripheral blood renal tissue SLE mice were examined by flow cytometry confocal microscopy, respectively. Sorting-purified PCs from adoptively transferred into Rag2-deficient recipients, which deposition pathology investigated. culture, treated a...
Abstract Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected cells activate lung γδ T to produce interleukin 17 A (IL-17A) early protection against H1N1 influenza infection. During infection, the cell pool constantly supplemented thymic output, with recent emigrants infiltrating into parenchyma airway acquire tissue-resident feature. Single-cell studies identify...
Circular RNAs (circRNAs) represent a newly identified class of non-coding that have been shown to be involved in several diseases, including autoimmune diseases. Two studies revealed the aberrant circRNA expression profiles peripheral blood mononuclear cells (PBMCs) patients with rheumatoid arthritis (RA) by microarrays. However, due intrinsic defects microarrays, such as their inability detect unidentified circRNAs, we examined PBMCs from four RA and three healthy controls RNA sequencing...
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterised by the autoinflammation and necrosis of blood vessel walls. The renal involvement commonly a pauci-immune crescentic glomerulonephritis (PiCGN) with very rapid decline in function. Cathelicidin LL37, an endogenous antimicrobial peptide, has recently been implicated pathogenesis autoimmune diseases. To assess whether serum LL37 reflects formation, we measured levels AAV patients without (crescentic GN) as...
Lupus nephritis is a rare immunological disorder. Genetic factors are considered important in its causation. We aim to systematically investigate the pathogenic gene variants patients with lupus nephritis.
<i>Background:</i> Renal tubular epithelial cells (TECs) function as antigen-presenting (APCs) they constitutively express MHC-II molecules and have the capacity to present peptide antigen T cells. Nevertheless, co-stimulatory signals provided by TECs for regulating cell activation not been fully characterized. We therefore investigated expression of B7-H1, a member B7 superfamily, on under normal or pathologic conditions in vivo analyzed regulation functional role it after...
Assisted reproductive technology (ART) is associated with increased metabolic risks in offspring. The effect of high maternal estradiol (E2) levels during early pregnancy on the glucose metabolism offspring remains unclear.
Newly identified PD-1hiCXCR5-CD4+ T-cells, termed as peripheral helper T-cells (Tph), have been found elevated and playing a pathogenic role in some autoimmune diseases like systemic lupus erythematosus (SLE) rheumatic arthritis (RA). However, the potential of Tph-cells anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) remains unclear. Here, we explored clinical significance circulating pathogenesis AAV. Comparing 32 active AAV patients 18 age- sex-matched healthy...
The increased emergence of multidrug‐resistant bacteria is perceived as a critical public health threat, creating an urgent need for the development novel classes antimicrobials. Cell‐penetrating peptides that share common features with antimicrobial have been found to activity and are currently being considered potential alternatives antibiotics. Transportan 10 chimeric cell‐penetrating peptide has reported transport biologically relevant cargoes into mammalian cells cause damage microbial...
Menadione is commonly used as an O 2 •− generator in studies into oxidative stress responses. However, the precise mechanism through which menadione mediates cellular generation, well way cells respond, remains unclear.
Objective: To explore and develop a new in vitro implantation model that reflects the main process of embryo attachment invasion. Study design: One limitations human research is lack an available faithfully replicates embryo–uterine interactions. In present study, we examined invasiveness blastocysts from mice Ishikawa cell (IK), endometrial cell, to clarify whether this suitable study embryos. We used IK placed it contact with initiate coculture experiments using specifically designed...
It is widely believed that endometrial atrophy in postmenopausal women due to an age-related reduction estrogen level. But the role of high circulating follicle-stimulating hormone (FSH) syndrome not clear. Here, we explored FSH physiological atrophy. We found exacerbated post-OVX mice, and this effect was ameliorated by lowering with Gonadotrophin-releasing agonist (GnRHa). In vitro, inhibited proliferation promoted apoptosis primary cultured cells a dose-dependent manner. addition,...
Myeloid cells have a critical role in maintaining intestinal homeostasis and regulating the development of inflammatory bowel disease colitis-associated cancer (CAC). However, signaling pathways that control function colonic myeloid these pathological processes are still poorly defined. In this study, we demonstrate transforming growth factor-β (TGF-β) is significantly involved CAC. TGF-β receptor II (Tgfbr2)-deficient mice showed reduced susceptibility to chemically induced tumorigenesis,...