A5073544051- Respiratory viral infections research
- Immune Response and Inflammation
- Endodontics and Root Canal Treatments
- Dental Radiography and Imaging
- Immunodeficiency and Autoimmune Disorders
- Virus-based gene therapy research
- Pneumonia and Respiratory Infections
- dental development and anomalies
- Bioactive Compounds and Antitumor Agents
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microbial Natural Products and Biosynthesis
- Cytokine Signaling Pathways and Interactions
- Synthesis of Indole Derivatives
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- T-cell and B-cell Immunology
- Viral gastroenteritis research and epidemiology
- Genomics and Phylogenetic Studies
- Systemic Lupus Erythematosus Research
- Peptidase Inhibition and Analysis
- Autoimmune and Inflammatory Disorders Research
- Dental Trauma and Treatments
- Adenosine and Purinergic Signaling
- Apelin-related biomedical research
- Inflammasome and immune disorders
Guangzhou Medical University
2019-2025
State Key Laboratory of Respiratory Disease
2020-2025
Guangdong Academy of Medical Sciences
2021-2024
Southern Medical University
2023-2024
Guangdong Provincial People's Hospital
2021-2024
ShenZhen People’s Hospital
2022
Sun Yat-sen University
2009-2021
Guangzhou Women and Children Medical Center
2020
Guangzhou Institute of Dermatology
2018
University of Hong Kong
2012
Abstract Rare genetic variants in toll-like receptor 7 (TLR7) are known to cause lupus humans and mice. UNC93B1 is a transmembrane protein that regulates TLR7 localization into endosomes. In the present study, we identify two new (T314A, located proximally domain, V117L) cohort of east Asian patients with childhood-onset systemic erythematosus. The V117L variant was associated increased expression type I interferons NF-κB-dependent cytokines patient plasma immortalized B cells. THP-1 cells...
Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In examining bronchoalveolar lavages (BALs) with CAP, we found that interleukin-17 (IL-17) production was significantly increased severe CAP. Immune profiling showed mucosal-associated invariant T (MAIT) cells from BALs, but not blood, CAP patients actively produced IL-17 (MAIT17). Single-cell RNA-sequencing revealed MAIT17 resided a BAL-resident PLZFhiCD103+ MAIT...
BackgroundMonogenic autoinflammatory disorders are characterized by dysregulation of the innate immune system, for example gain-of-function mutations in inflammasome-forming proteins, such as NOD-like receptor family CARD-containing 4 protein (NLRC4).ObjectiveHere we investigate mechanism which a novel mutation leucine-rich repeat (LRR) domain NLRC4 (c.G1965C, p.W655C) contributes to disease. Methods: We studied 2 unrelated patients with early-onset macrophage activation syndrome harboring...
A novel series of xyloketal derivatives (1−21) were designed and prepared. The majority the compounds demonstrated vasorelaxation action on 60 mM KCl-induced contractions rat isolated aortic rings in a concentration-dependent manner, is mediated by both endothelium-independent endothelium-dependent mechanisms. Compounds 9, 12, 13, 14, 15, 19 showed higher activities comparing with lead compound 3. In addition, these had potential protective against oxLDL-induced endothelial oxidative injury...
Abstract Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected cells activate lung γδ T to produce interleukin 17 A (IL-17A) early protection against H1N1 influenza infection. During infection, the cell pool constantly supplemented thymic output, with recent emigrants infiltrating into parenchyma airway acquire tissue-resident feature. Single-cell studies identify...
Background Echovirus type 11(E-11) can cause fatal haemorrhage-hepatitis syndrome in neonates. This study aims to investigate clinical risk factors and early markers of E-11 associated neonatal syndrome. Methods is a multicentre retrospective cohort 105 neonates with infection China. Patients (the severe group) were compared those mild disease. Clinical analysed. In addition, cytokine analysis performed selective patients explore the immune responses. Results addition prematurity, low birth...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of disease 2019 (COVID-19), has had a significant impact on healthcare systems and economies worldwide. The continuous emergence new viral strains presents major challenge in development effective antiviral agents. Strategies that possess broad-spectrum activities are desirable to control SARS-CoV-2 infection. ACE2, an angiotensin-containing enzyme prevents overactivation renin angiotensin system, is...
Inorganic polyphosphate (poly-P), guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp) are ubiquitous in bacteria. These molecules play a variety of important physiological roles associated with stress resistance, persistence, virulence. In the bacterial pathogen Mycobacterium tuberculosis, identities proteins responsible for metabolism (p)ppGpp remain to be fully established. M. tuberculosis encodes two PPX-GppA homologues, Rv0496 (MTB-PPX1) Rv1026, which share significant sequence...
The pathogenesis of Mycoplasma pneumoniae pneumonia (MPP), specifically the local immune responses in lungs, is poorly understood. In this study, flow cytometry was used to analyze IL-17 and related cytokines plasma bronchoalveolar lavage fluid (BALF) samples from 18 30 pediatric patients with general MPP (GMPP) refractory (RMPP), respectively. levels IL-1Ra, IL-6, IL-8, IL-17, TNF-α were significantly elevated BALF children compared (P < 0.01). Although IL-6 RMPP higher than those GMPP...
Background Human adenoviruses (HAdV) infection caused pneumonia remains a major threat to global children health. Currently, diagnosis of severe HAdV in is hampered by the lack specific biomarkers. Also, severity adenovirus pediatric patients generally based on clinical features and existing biomarkers do not reliably correlate severity. Here, we asked whether local systemic inflammatory mediators could act as predicting children. Methods Totally 37 common protein levels were determined...
The effective remission of acute respiratory distress syndrome- (ARDS-) caused pulmonary fibrosis determines the recovery lung function. Inositol can relieve injuries induced by ARDS. However, mechanism myo-inositol in development ARDS is unclear, which limits its use clinic. We explored role and using an vitro lipopolysaccharide- (LPS-) established alveolar epithelial cell inflammation model vivo mouse model. Our results showed that inositol alleviate progression fibrosis. More...
Abstract A novel metabolite xylopyridine ( 1 ), together with a known compound pyrocoll 2 was isolated from mangrove endophytic fungus Xylaria sp. (#2508) collected the South China Sea coast. Their structures were established on basis of spectroscopic analysis, especially 2D‐NMR. affinities toward calf thymus (CT) DNA studied by fluorescence quenching and spectrophotometric titration experiments. The results indicate that showes strong DNA‐binding affinity presumably via an intercalation...
Abstract Background Severe pneumonia frequently causes irreversible sequelae and represents a major health burden for children under the age of 5. Matrix Metallopeptidase 9 (MMP9) is zinc-dependent endopeptidase that involved in various cellular processes. The correlation between MMP9 risk severe childhood remains unclear. Methods Here we assemble case–control cohort to study association genetic variants gene with susceptibility Southern Chinese population (1034 cases 8426 controls). Results...
Xyloketals, a new type of antioxidants from marine mangrove fungus, have potential pharmacological properties. In this paper, the radical-scavenging activities series synthetic xyloketals and related chromanes toward 2,2-diphenyl-1-picrylhydrazyl (DPPH) 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) were evaluated by absorption spectrometry. One compounds (compound 10) displayed significant antioxidative action against DPPH ABTS. A structure-activity analysis showed that...
Abstract A mild and efficient protocol for the synthesis of benzopyran ring has been described a series chromans compounds is reported, yield from 72% to 95%. The diadduct tended angular product showed good regioselectivity. This strategy was applied derived natural products (±)‐xyloketals (±)‐alboatrin. crystal compound 9 exhibited centro‐symmetric space group, containing two isomers in one unit. relative configurations were 1 R ,10 ,15 S 34 ,22 ,30 , respectively.
Morphological analysis of permanent anterior dentition is essential for achieving an ideal treatment outcome and avoiding unnecessary failure. This study aimed to analyze the morphologies teeth in Chinese population depth.In this retrospective study, 4309 from 401 patients were investigated using cone-beam computed tomography (CBCT) 2019-2021. We summarized morphological characteristics terms root length, cementoenamel junction curvature (CEJ-C), furcation canal variations.We found that...
Abstract Rare genetic variants in TLR7 are known to cause lupus humans and mice. UNC93B1 is a transmembrane protein that regulates localisation into endosomes, however it has only been genetically linked mice dogs. We now identify novel variant (T314A) located proximally the domain, patient with childhood-onset systemic erythematosus (SLE). Further examination cohort of East Asian patients revealed seven who encode (V117L), which rare but highly significant risk factor for this disease, when...
Severe community-acquired pneumonia (sCAP) early in life is a leading cause of morbidity, mortality, and irreversible sequelae. Herein, we report the clinical, etiological, immunological characteristics 62 children <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mtext>age</mtext> <mo><</mo> <mn>1</mn> </math> year. We measured 27 cytokines plasma bronchoalveolar lavage (BAL) from id="M2"> year who were diagnosed with CAP, then, analyzed correlations among disease severity,...
Chronic granulomatous disease (CGD) is caused by gene mutations that affect the phagocyte NADPH oxidase. This results in recurrent infections catalase-positive bacteria or fungi. Here, we report a case of X-linked CGD presenting mixed infection with Burkholderia cepacia and Aspergillus. A novel mutation was found bioinformatics analyses his genealogy (c.1234delG), which perhaps changed structure function related proteins.