A5103214863- Plant nutrient uptake and metabolism
- Plant Disease Resistance and Genetics
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Psoriasis: Treatment and Pathogenesis
- Mitochondrial Function and Pathology
- Dermatology and Skin Diseases
- ATP Synthase and ATPases Research
- IL-33, ST2, and ILC Pathways
- Parasitic Infections and Diagnostics
- Legume Nitrogen Fixing Symbiosis
- Immune Cell Function and Interaction
- Plant Stress Responses and Tolerance
- Antifungal resistance and susceptibility
- T-cell and B-cell Immunology
- Medical and Biological Ozone Research
- Amoebic Infections and Treatments
- Lymphatic System and Diseases
- Biological and pharmacological studies of plants
- Laser Applications in Dentistry and Medicine
- Autoimmune and Inflammatory Disorders Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Single-cell and spatial transcriptomics
- Parasitic infections in humans and animals
- Bioactive natural compounds
Southern Medical University
2021-2025
Institute of Dermatology
2024
Beijing Graphene Institute
2020-2024
BGI Research
2024
Qingdao Agricultural University
2021
University of Hong Kong
2014-2020
First Hospital of China Medical University
2019
China Medical University
2017-2019
Ministry of Education of the People's Republic of China
2019
Deleted Institution
2019
miR396 targets seven GROWTH-REGULATING FACTOR (GRF) genes and the BASIC HELIX–LOOP–HELIX (bHLH) TRANSCRIPTION 74 gene (bHLH74) in Arabidopsis. Previous research revealed that target module regulates cell proliferation plays a critical role leaf development. However, no additional biological functions of have been investigated detail. In this study, T-DNA insertion mutants transgenic plants with altered levels or its were used to characterize regulatory root We found AtMIR396a was predominant...
Previously, several long non-coding RNAs (lncRNAs) were characterized as regulators in phosphate (Pi) starvation responses. However, systematic studies of novel lncRNAs involved the Pi signaling pathways have not been reported. Here, we used a genome-wide sequencing and bioinformatics approach to identify both poly(A) + poly(A)– that responded Arabidopsis thaliana. We sequenced shoot root transcriptomes seedlings grown under Pi-sufficient Pi-deficient conditions, predicted 1212 lncRNAs,...
Significance By studying in vivo changes of ATP levels the plastids and cytosol Arabidopsis thaliana using a FRET-based sensor, we show that plastidic concentrations cotyledon, hypocotyl, root 10-day-old seedlings are significantly lower than cytosolic concentrations. We chloroplasts consume rapidly import into mature is impeded by low density NTT transporter. Hence, unlike diatoms, where imported to support Calvin–Benson–Bassham (CBB) cycle, do not balance ATP:NADPH ratio importing from...
Psoriasis is an immune‑mediated cutaneous disorder with a high incidence and prevalence. Patients psoriasis may experience irritation, pain psychological problems. The cause underlying molecular etiology of remains unknown. In attempt to achieve more comprehensive understanding the pathogenesis psoriasis, gene expression profiles 175 pairs lesional corresponding non‑lesional skin samples were downloaded from 5 data sets in Gene Expression Omnibus (GEO) database. Integrated differentially...
Chloroplasts and mitochondria are the major ATP producing organelles in plant leaves. Arabidopsis thaliana purple acid phosphatase 2 (AtPAP2) is a dually targeted to outer membranes of both it plays role import selected nuclear-encoded proteins into these two organelles. Overexpression (OE) AtPAP2 accelerates growth promotes flowering, seed yield biomass at maturity. Measurement ADP/ATP/NADP+/NADPH contents leaves 20-day-old OE wild-type lines end night 1 8 h following illumination 16/8...
A higher prevalence of hyperuricemia is observed in psoriasis, yet the precise involvement psoriasis remains unclear. Therefore, we investigated relationship between and as well potential mechanisms through which may promote psoriatic inflammation. Firstly, a literature review on serum uric acid (SUA) levels retrospective analysis PASI scores SUA 147 patients at Dermatology Hospital Southern Medical University were performed. Then mouse models established to assess impact psoriasis. Finally,...
Enterocytozoon ( E. ) bieneusi and Cryptosporidium spp. are the most important zoonotic enteric pathogens associated with diarrheal diseases in animals humans. However, it is still not known whether carried by wild rodents Shanxi, Guangxi, Zhejiang, Shandong, Inner Mongolia, China. In present study, a total of 536 feces samples were collected from Rattus (R.) norvegicus , Mus musculus Spermophilus S. dauricus Lasiopodomys brandti six provinces China, detected PCR amplification SSU rRNA gene...
The immune system of skin develops in stages mice. However, the developmental dynamics cells human remains elusive. Here, we perform transcriptome profiling CD45+ hematopoietic fetal at an estimated gestational age 10–17 weeks by single-cell RNA sequencing. A total 13 cell types are identified. Skin macrophages show dynamic heterogeneity over course development. major shift lymphoid states occurs from first to second trimester that implies situ differentiation process. Gene expression...
As a potent pro-inflammatory cytokine of the interleukin (IL)-1 family, IL-18 was elevated in early active and progressive plaque-type psoriatic lesions that serum or plasma levels correlated with Psoriasis Area Severity Index (PASI). Although results from previous studies have established may aggravate inflammation, mechanisms this process remain unknown. In study, knock out (KO) mice wild-type (WT) were used to investigate effects within mouse model psoriasis.WT KO divided into four...
Rationale: Systemic sclerosis (SSc) is a chronic and incurable autoimmune disease with high mortality rates, skin fibrosis one of distinguishing hallmarks in the pathogenesis.However, macrophage heterogeneity regulating remain largely unknown.Methods: We established mouse model performed single-cell RNA-sequencing (scRNA-seq) to resolve dynamic heterogenous characteristics macrophages fibrosis, role TREM2-dependent pathological process was investigated using knockout mice intraperitoneal...
Abstract Organ fibrosis represents a vital health threat that substantially contributes to yearly mortality rates. While considerable amount of research has been conducted on fibrosis, these reports have only focused specific organs as affected within distinct disorders. Accordingly, results from such studies unable provide comprehensive understanding the pathological processes involved. Here, we describe development FibROAD, an open-access database integrates evidence fibrosis-associated...
Abstract Background In higher eukaryotes, small RNAs play a role in regulating gene expression. Overexpression (OE) lines of Arabidopsis thaliana purple acid phosphatase 2 (AtPAP2) were shown to grow faster and exhibit ATP sugar contents. Leaf microarray studies showed that many genes involved microRNAs (miRNAs) trans-acting siRNAs (tasiRNAs) biogenesis significantly changed the fast-growing lines. this study, sRNA profiles leaf root 20-day-old plants sequenced impacts high energy status on...
Phosphorylation of the transit peptides nuclear-encoded preprotein is a well-known regulatory process protein import in plant chloroplasts. In Arabidopsis Protein Site Database, 103 out 802 mitochondrial proteins were found to contain one or more experimentally proven phosphorylation sites their first 60 amino acid residues. Analysis N-terminal sequences selected preproteins and homologs from 64 species showed high conservation among sites. The ability kinases various sources including leaf...
Disease resistance exerts a fitness cost on plants, presumably due to the extra consumption of energy and carbon. In this study, we examined whether transgenic Arabidopsis thaliana with increased levels ATP sucrose is more resistant or susceptible pathogen infection. Lines A. over-expressing purple acid phosphatase 2 (AtPAP2) (OE lines) contain sucrose, improved growth rate seed production. Compared wild type (WT) pap2 lines, OE lines were several Pseudomonas syringae pv. tomato (Pst)...
Small RNAs, including microRNAs (miRNAs) and phased small interfering RNAs (phasiRNAs; from PHAS loci), play key roles in plant development. Cultivated soybean, Glycine max, contributes a great deal to food production, but, compared its wild kin, soja, it may lose some genetic information during domestication. In this work, we analyzed the sRNA profiles of different tissues both cultivated (C08) soybeans (W05) at three stages A total 443 known miRNAs 15 novel showed varying abundances...
Overexpression of AtPAP2, a phosphatase located on the outer membranes chloroplasts and mitochondria, leads to higher energy outputs from these organelles. AtPAP2 interacts with seven MORF proteins editosome complex. RNA-sequencing analysis showed that editing degrees most sites did not differ significantly between OE WT, except some transcripts several cytochrome c maturation (Ccm) genes. Western blotting 2D BN-PAGE patterns CcmFN1 polypeptides were different lines. We proposed may...
Nitrogen fixation in soybean consumes a tremendous amount of energy, leading to substantial differences energy metabolism and mitochondrial activities between nodules uninoculated roots. While C-to-U RNA editing intron splicing transcripts are common plant species, their roles relation nodule functions still elusive. In this study, we performed RNA-seq compare transcript profiles genes A total 631 sites were identified on transcripts, with 12% or 74 differentially edited among the isolated...
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Blastocystis is a protozoan that parasitizes the intestines. A number of hosts have been found, including human and animals. However, there has no research on prevalence in Tibetan antelope. Here, molecular test was performed using 627 antelope fecal samples collected Tibet China from 2019 to 2020. The result showed 30 (4.8%) were positive. highest Shuanghu County (25/209, 12.0%), followed by Shenza (2/103, 1.9%), Nyima (3/182, 1.6%), Baigoin (0/133, 0.0%). In addition, logistic regression...