A5115596245- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Virus-based gene therapy research
- Plant tissue culture and regeneration
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- Crystallography and molecular interactions
- Supercapacitor Materials and Fabrication
- SARS-CoV-2 and COVID-19 Research
- Potato Plant Research
- Catalytic C–H Functionalization Methods
- Metabolism and Genetic Disorders
- Immunotherapy and Immune Responses
- Hepatitis C virus research
- Cancer Treatment and Pharmacology
- Viral Infections and Vectors
- Metal and Thin Film Mechanics
- Mosquito-borne diseases and control
- melanin and skin pigmentation
- RNA modifications and cancer
- Plant Molecular Biology Research
- Advancements in Battery Materials
- Antenna Design and Analysis
- MicroRNA in disease regulation
- Organophosphorus compounds synthesis
University of Liverpool
2017-2025
National University of Defense Technology
2024-2025
Beijing Institute of Technology
2019-2025
Xiamen University
2012-2025
Beijing Forestry University
2024-2025
State Ethnic Affairs Commission
2024-2025
Ministry of Industry and Information Technology
2024-2025
Aerospace Center Hospital
2025
Shanghai University of Electric Power
2025
Zhongshan Hospital
2025
Resveratrol, extracted from Chinese herbal medicine Polygonum cuspidatum, is known to inhibit invasion and metastasis of human colorectal cancer (CRC), in which long non-coding Metastasis Associated Lung Adenocarcinoma Transcript 1 (RNA-MALAT1) also plays an important role. Using MALAT1 lentiviral shRNA over-expression constructs CRC derived cell lines, LoVo HCT116, we demonstrated that the anti-tumor effects resveratrol on are through inhibiting Wnt/β-catenin signaling, thus expression its...
The neutrophil-to-lymphocyte ratio (NLR) is an easily accessible biological marker that has been reported to represent disease severity. aim of this study investigate the association between NLR and mortality in patients with sepsis.A total 333 consecutive adult sepsis were screened for eligibility prospective, observational cohort. Severity scores leukocyte counts prospectively recorded upon entry intensive care unit (ICU). Receiver operating characteristic (ROC) curves binary logistic...
Currently, various oncolytic adenoviruses (OA) are being explored in both preclinical and clinical virotherapy. However, the pre-existing neutralizing antibodies (nAbs) poor targeting delivery major obstacles for systemically administered OA. Therefore, we designed bioengineered cell membrane nanovesicles (BCMNs) that harbor ligands to achieve robust antiviral immune shielding capabilities We employed two distinct biomimetic synthetic approaches: first is based on vitro genetic engineering...
<h3>Objective</h3> This study aimed to investigate the therapeutic potential of monoclonal antibody (mAb) against HBV as a novel treatment approach chronic hepatitis B (CHB) in mouse models. <h3>Methods</h3> Therapeutic effects mAbs various epitopes on viral surface protein were evaluated mice mimicking persistent infection. The immunological mechanisms mAb-mediated clearance systematically investigated. <h3>Results</h3> Among 11 tested mAbs, mAb E6F6 exhibited most striking several...
p-Hydroxybenzaldehyde thiosemicarbazone (HBT) and p-methoxybenzaldehyde (MBT) were synthesized established by 1H NMR mass spectra. Both compounds evaluated for their inhibition activities on mushroom tyrosinase free-cell melanoma production from B16 mouse cells. Results showed that both exhibited significant inhibitory effects the enzyme activities. HBT MBT decreased steady state of monophenolase activity sharply, IC50 values estimated as 0.76 7.0 μM, respectively. lengthened lag time, but...
520 Background: Clinical studies suggest that TNBC is sensitive to DNA-damaging agents, including Cb. V a potent PARP inhibitor may enhance the antitumor activity of such agents. We present primary response data from phase 3 randomized, placebo-controlled study (NCT02032277) evaluating addition + Cb or neoadjuvant paclitaxel (P) followed by doxorubicin cyclophosphamide (AC). Methods: Pts with histologically confirmed, invasive (T2–T4 N0–2 T1 N1–2) amenable surgical resection were randomized...
An effective multicomponent reaction for the synthesis of 4-phosphorylated 4H-chromenes via a tandem phosphorylation/alkylation/cyclization/dehydration sequence with water as only byproduct was developed. Extensive mechanistic investigations involving in situ NMR experiments, time control and HRMS experiment allowed us to elucidate order each subreaction arrive at complete understanding underlying mechanism this reaction. Mechanistic data confirm that begins phospha-aldol-elimination,...
This study examines the economic impact of soaring international energy prices during Russia-Ukraine conflict from February 23, 2022, to May 31, 2022. Notably, by applying a CGE model, this offers insights into policies at both macroeconomic and industrial levels, emphasizing model's utility in analyzing complex interactions under geopolitical stress. Findings indicate that:
Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease with strong genetic component. Genetic burden higher in children when compared to patients adult-onset SLE, contributing earlier expression and more severe phenotypes. The human leukocyte antigen (HLA) cluster on chromosome 6p21.3 among the most variable genomic regions, representing major risk-factor for SLE adults. Its impact juvenile-onset (j)SLE remains largely unstudied. High-resolution sequencing of HLA...
An efficient phospha-aldol/Meyer-Schuster rearrangement cascade reaction between propargylic aldehydes and phosphine oxides has been developed in which various phosphoryl enones were obtained moderate to excellent yields. A comprehensive series of mechanistic experiments, including the identification key intermediates application 18O isotope labeling, confirmed that this proceeds through a phospha-aldol followed by Meyer–Schuster reaction.
Converters play a critical role in wind power generation systems, with their reliability directly impacting system stability and operational efficiency. To address the challenges posed by increased thermal load fluctuations due to solder layer aging insulated gate bipolar transistor (IGBT) modules converters, this paper proposes an aging-aware multi-objective management (AAMO-TM) strategy enhance performance of modules. An improved junction temperature estimation model is developed,...
Viruses have evolved multiple mechanisms to counteract the stimulator of interferon genes (STING) pathway, resulting in suppression antiviral responses. Accordingly, addition developing STING agonist analogs with enhanced stability and deliverability, overcoming defective function virus-infected cells is essential for defense against viral infections. In this study, we developed pathway-activating complexes (SPAC) based on bioinspired vesicles that display multimerize molecules a specific...