A5100442204- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Biosensors and Analytical Detection
- Immunotherapy and Immune Responses
- Photoacoustic and Ultrasonic Imaging
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Luminescence Properties of Advanced Materials
- Real-time simulation and control systems
- Dermatologic Treatments and Research
- Software Testing and Debugging Techniques
- Mosquito-borne diseases and control
- Electrohydrodynamics and Fluid Dynamics
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Advanced Nanomaterials in Catalysis
- Ferroptosis and cancer prognosis
- Perovskite Materials and Applications
- MicroRNA in disease regulation
- Luminescence and Fluorescent Materials
- Mechanical stress and fatigue analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
Xiamen University
2018-2025
Northwestern University
2024-2025
Neurological Surgery
2024-2025
Harbin Engineering University
2020-2024
Peking University People's Hospital
2021-2024
Peking University
2021-2024
Yueyang Hospital
2020
Shanghai University of Traditional Chinese Medicine
2020
Yantaishan Hospital
2017
Abstract Precise anti‐cancer therapy is hampered by aberrant tumor microenvironments (TME), which include the important features of dense extracellular matrix (ECM) and hypoxia. The capability hyaluronidase (HAase) to degrade hyaluronic acid (HA), main component ECM, can prompt its rapid development in sonotherapeutics aimed at regulating microenvironment. In this study, authors design a bioengineering‐based smart enzymatic nanovesicle mHAase combined with purpurin 18 (P18) form mHAase@nP18...
Despite recent advancements of sonodynamic therapy (SDT) in cancer immunotherapy, challenges have yet to be surmounted further boost its immunotherapeutic efficacy due the low-level tumor antigens presentation dendritic cells (DCs). Cell membrane camouflaged-nanoparticles can integrate neoantigens cell with multifunctionalities synthetic nanocores. Herein, sono-responsive nanoparticles coated DC-targeted antibody chimeric are investigated for multimodal therapy. The nanometal organic...
Melittin, the principal constituent in bee venom, is an attractive candidate for cancer therapy. However, its clinical applications are limited by hemolysis, nonspecific cytotoxicity, and rapid metabolism. Herein, a novel genetically engineered vesicular antibody-melittin (VAM) drug delivery platform was proposed validated targeted combination VAM generated from cellular plasma membrane bio-synthetically fabricated, with recombinant protein (hGC33 scFv-melittin) being harbored displayed on...
It is an engaging program for tumor treatment that rationalizes the specific microenvironments, activation of suppressed immune system (immune resistance/escape reversion), and synergistic target therapy. Herein, a biomimetic nanoplatform combines oxidative stress with genetic immunotherapy to strengthen therapeutic efficacy developed. Ru-TePt nanorods, small interfering RNA (PD-L1 siRNA), cellular membrane vesicles targeting ability design multifunctional Ru-TePt@siRNA-MVs are rationally...
Viruses have evolved multiple mechanisms to counteract the stimulator of interferon genes (STING) pathway, resulting in suppression antiviral responses. Accordingly, addition developing STING agonist analogs with enhanced stability and deliverability, overcoming defective function virus-infected cells is essential for defense against viral infections. In this study, we developed pathway-activating complexes (SPAC) based on bioinspired vesicles that display multimerize molecules a specific...
The incidence of cutaneous melanoma (CM) increased since the 1970s, and also along with an unfavorable prognosis.CM patients have been verified benefits from immunotherapy, granzymes (GZMs) comprise more than 90% cytolytic granules secreted by cytotoxic T lymphocytes nature killer cell.Therefore, it is essential to evaluate prognostic value GZMs in CM.A total 633 CM was enrolled access GZMs.The integrated five validated TCGA-SKCM, GSE65904, GSE53118, GSE19234 GSE22153 cohorts.GZMscore, age,...
In view of the complex procedure nucleic acid extraction, there exists a huge challenge for widespread use point-of-care diagnostics testing. To achieve applications in more rapid and cost-efficient manner, we designed snake pipe-shaped microfluidic chip so as to accomplish reagents-prestored, time-saving, operation-simple extraction. All reagents needed this process, including lysis buffer, wash elution on, were preloaded pipe securely isolated by membrane valves, without need using any...
Abstract Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely appropriate triggering is crucial to inhibit viral replication prevent ARDS. However, current medical countermeasures can rarely meet this urgent demand. Here, an nanobiologic named CoVR‐MV developed, which polymerized CoVs receptors based on...
The shortcomings of standard plasma-separation methods limit the point-of-care application microfluidics in clinical facilities and at patient's bedside. To overcome limitations this inconvenient, laborious, costly technique, a new technique device were developed. This separation method relies on immunological capture filtration to exclude cells from plasma, is convenient, easy use, cost-effective. Most RBCs can be captured immobilized by antibody which coated matrix, residue totally removed...
Upon harnessing low-intensity ultrasound to activate sonosensitizers, sonodynamic therapy (SDT) induces cancer cell death through the reactive oxygen species (ROS) mediated pathway. Compared with photodynamic (PDT), SDT possesses numerous advantages, including deeper tissue penetration, higher accuracy, fewer side effects, and better patient compliance. Sinoporphyrin sodium (DVDMS), a sonosensitizer approved by FDA, has drawn abundant attention in clinical research, but there are some...
To fulfill the requirement of sample preparation in a microfluidic analysis system designed for "sample in, answer out" testing which was urgently needed by resource limited clinical facilities, we proposed critical low cost, membrane-based serum separator design this article. With specially microchip, device can easily separate from whole blood 5 min. Different techniques have been reported earlier, approach does not require either centrifugation or dilution may cause hemolysis decreased...
The activation of CD8+ cytotoxic T-lymphocytes (CTLs) plays the central role in cancer immunotherapy, which depends on efficient recognition peptide-major histocompatibility complex (pMHC) by T cell receptor (TCR) for first signal, and B7-CD28 co-stimulating second signal. To achieve potent immune stimulatory effect, a genetically engineered cellular membrane nanovesicles platform that integrates antigen self-presentation immunosuppression reversal (ASPIRE) immunotherapy was designed. In...
145 Background: Clinical trials have shown that adoptive cell transfer therapy is a promising method for cancer treatment. In the current study, we aim to generate and characterize anti-tumor tumor-infiltrating lymphocytes from patients with breast therapy. Methods: vitro culture was used anti-tumor, cancer. FACS analysis, ELISA, Elispot assay were lymphocytes. Autologous in Results: analysis indicated present tumor tissues, but not detectable normal tissues Tumor-infiltrating could be...