A5101784238- Cancer-related molecular mechanisms research
- Respiratory viral infections research
- RNA modifications and cancer
- Influenza Virus Research Studies
- Cytokine Signaling Pathways and Interactions
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Estrogen and related hormone effects
- Circular RNAs in diseases
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Adipose Tissue and Metabolism
- Microbial Metabolism and Applications
- Sepsis Diagnosis and Treatment
- Menopause: Health Impacts and Treatments
- Cancer Immunotherapy and Biomarkers
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological Disease Mechanisms and Treatments
- Immune cells in cancer
- interferon and immune responses
- Acute Ischemic Stroke Management
- Muscle Physiology and Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Mycobacterium research and diagnosis
- Alzheimer's disease research and treatments
Second Affiliated Hospital of Zhejiang University
2021-2025
Zhejiang University
2016-2025
Jilin University
2021-2023
Nantong University
2022
Yancheng First People's Hospital
2022
Zhejiang Chinese Medical University
2019-2021
Hangzhou Hospital of Traditional Chinese Medicine
2020-2021
Zhejiang Hospital
2020-2021
Southeast University
2020
Weatherford College
2020
The neutrophil-to-lymphocyte ratio (NLR) is an easily accessible biological marker that has been reported to represent disease severity. aim of this study investigate the association between NLR and mortality in patients with sepsis.A total 333 consecutive adult sepsis were screened for eligibility prospective, observational cohort. Severity scores leukocyte counts prospectively recorded upon entry intensive care unit (ICU). Receiver operating characteristic (ROC) curves binary logistic...
The neuronal loss associated with Alzheimer's disease (AD) affects areas of the brain that are vital to cognition. Although recent studies have shown new neurons can be generated from progenitor cells in neocortices healthy adults, neurogenic potential stem/progenitor AD patients is not known. To answer this question, we compared properties glial (GPCs) cortices control (HC) and subjects. GPCs samples displayed reduced renewal capability neurogenesis HC brains. investigate mechanisms...
Accumulating evidence suggests that mitochondria are important targets for the actions of estrogens and studies indicated localization estrogen receptor β (ERβ) in neuronal mitochondrial (mtERβ) might directly affect function vitro. However, it is unknown what expression levels how mtERβ human brain, particularly a brain with Alzheimer's disease (AD). In present study, using rapidly autopsied tissue, we found frontal cortices female AD patients exhibited significantly reduced mtERβ, along...
In this study, we investigated the neuroprotective potential of resveratrol against oxygen glucose deprivation/reoxygenation (OGD/R)-induced apoptotic damages in well-differentiated PC12 cells and underlying mechanisms. Cells were incubated under normal condition or OGD/R presence absence 10 μM resveratrol. Cell viability was determined with methyl-thiazolyl-tetrazolium (MTT) assay. Apoptotic ratio Hoechst 33342 staining Annexin V-FITC/PI double staining. Oxidative stress evaluated by...
The effect of loop diuretic use in critically ill patients on vasopressor support or shock is unclear. This study aimed to explore the relationship between and hospital mortality with support. Data were extracted from Medical Information Mart for Intensive Care III database. Adult records within 48 h after intensive care unit admission screened. Multivariable logistic regression propensity score matching was used investigate any association. 7828 included. crude significantly lower (166/1469...
Highlights•Riok3 negatively and selectively inhibits RNA viruses both in vivo vitro•Riok3 directly interacts with TRIM40, RIG-I, MDA5 to form a protein complex•Riok3 promotes TRIM40-mediated K27- K48-linked ubiquitination of RIG-I MDA5•TRIM40 induces the proteasomal degradation MDA5SummaryThe type I interferon (IFN) pathway is key component innate immune response upon invasion foreign pathogens. It also under precise control prevent excessive upregulation undesired inflammation cascade. In...
This study aimed to devise a breast cancer (BC) risk signature for based on pyrimidine metabolism-related genes (PMRGs) evaluate its prognostic value and association with drug sensitivity. Transcriptomic clinical data were retrieved from The Cancer Genome Atlas database Gene Expression Omnibus repository. Pyrimidine metabolism-associated identified the Molecular Signatures Database collection. A was constructed through Cox regression Lasso methods. Further, relationship between PMRG-derived...
Abstract This study was conducted to compare the effects of fish oil and olive supplementation in late pregnancy during lactation on oxidative stress inflammation sows their piglets. A total 24 were fed a basal diet supplemented with additional corn starch (CON), (FO) or (OO). Sows an OO gestation had higher piglet birth weight compared CON‐fed FO‐fed ( P < 0.05). Furthermore, from group milk fat content than CON FO groups, lower pre‐weaning mortality piglets observed Maternal resulted...
Abstract A series of benzolactam compounds were synthesized, some which caused a concentration‐dependent increase in sAPPα and decrease Aβ production the concentration range 0.1–10 μ M . Moreover, showed neuroprotective effects 10–20 HCA cortical neuron model oxidative stress no toxicity measurements viability by MTT assay, even at highest concentrations tested (20 ). magnified image Alzheimer's disease (AD) is well‐studied neurodegenerative process characterized presence amyloid plaques...
Timely risk stratification is the key strategy to improve prognosis of patients with sepsis. Previous study has proposed develop a powerful assessment rule by combination Acute Physiology and Chronic Health Evaluation II (APACHE II) score plasma soluble urokinase plasminogen activator receptor (suPAR). That reaffirmation suPAR as prognostic marker in Chinese severe sepsis aim study. A total 137 consecutive were enrolled prospective cohort. Demographic clinical characteristics, conventional...
Refined Qing Kai Ling (RQKL) is an improved injectable multi-component preparation derived from Ling, which could offer the neuroprotection effect in middle cerebral artery occlusion (MCAO) model of rats by relieving damage vascular endothelial cell as well inhibiting process inflammation. Herein, we observed whether RQKL exert influence on expression nitric oxide synthase (eNOS), a mechanism its protective effects against ischemia. Sprague-Dawley rat focal ischemia was established permanent...
The Chinese brown frog (Rana dybowskii) is a special amphibian with one unique physiological phenomenon, which that its oviduct expands prior to hibernation, instead of during the breeding period. In this study, we investigate localization and expression level PPARγ2, leptin receptor proteins in Rana dybowskii period pre-hibernation. There were significant variations oviductal weight size, values much lower than PPARγ2 was observed stromal epithelial cells both periods. Leptin...
Contents The effects of dietary β ‐hydroxy‐ ‐methylbutyrate ( HMB ) supplementation during gestation on reproductive performance sows and the mRNA expression myogenic markers in skeletal muscle neonatal pigs were determined. At day 35 gestation, a total 20 (Landrace × Yorkshire, at third parity) randomly assigned to two groups, with each group receiving either basal diet or same supplemented 4 g/day calcium ‐Ca) until parturition. parturition, live litter size not markedly different between...
This study investigated the effects of fetal rat umbilical cord compression on anatomical, biochemical, and behavioral parameters development. Further, examined ability calcium channel antagonist nimodipine to afford protection from this insult. Near day birth (E21), individual fetuses was not clamped or for 2, 6, 12 min. Before clamping, mothers were given 70 μg/kg (i.p.) in a polyethylene glycol (PEG) vehicle alone. Selected animals sacrificed cytochrome oxidase histochemistry. The...