A5101559905- Bioinformatics and Genomic Networks
- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Reliability and Agreement in Measurement
- Machine Learning in Bioinformatics
- Plant Gene Expression Analysis
- Macrophage Migration Inhibitory Factor
- Mobile Agent-Based Network Management
- Computational Drug Discovery Methods
- Single-cell and spatial transcriptomics
- Protein Structure and Dynamics
- Clinical Laboratory Practices and Quality Control
- Plant Molecular Biology Research
- Retinal Development and Disorders
- Statistical Methods in Epidemiology
- Multi-Criteria Decision Making
- Plant Stress Responses and Tolerance
- Biomedical Text Mining and Ontologies
- Microbial metabolism and enzyme function
- Hemodynamic Monitoring and Therapy
- Construction Project Management and Performance
- Retinal and Macular Surgery
- 14-3-3 protein interactions
- Mathematical Biology Tumor Growth
- Consumer Behavior in Brand Consumption and Identification
China Tobacco
2023-2024
Hubei University
2024
Qiqihar University
2022-2024
Jiangnan University
2013-2024
First Affiliated Hospital of Henan University
2022-2023
Qinghai University Affiliated Hospital
2023
National Clinical Research
2022
Guilin University of Technology
2021
Bioengineering Center
2021
Tianjin Fourth Central Hospital
2021
Berberine (BBR) has a neuroprotective effect against ischemic stroke, but its specific protective mechanism not been clearly elaborated. This study explored the of BBR on canopy FGF signaling regulator 2 (CNPY2) pathway in penumbra rats. The model cerebral ischemia-reperfusion injury (CIRI) was established by thread embolization method, and gastrically perfused for 48 h or 24 before operation 6 after operation. rats were randomly divided into four groups: Sham group, CIRI + group. After...
The physiological activities within cells are mainly regulated through protein-protein interactions (PPI). Therefore, studying protein has become an essential part of researching function and mechanisms. Traditional biological experiments required for PPI prediction expensive time consuming. For this reason, many methods based on predicting from sequences have been proposed in recent years. However, existing computational usually require the combination evolutionary feature information...
Modeling across multiple scales is a current challenge in Systems Biology, especially when applied to multicellular organisms. In this paper, we present an approach model at different spatial scales, using the new concept of Hierarchically Colored Petri Nets (HCPN). We apply HCPN tissue comprising cells hexagonally packed honeycomb formation order describe phenomenon Planar Cell Polarity (PCP) signaling Drosophila wing. have constructed family related models, permitting hypotheses be...
Aspergillus terreus is widely used for industrial production of important chemical compounds such as itaconate and lovastatin. To improve understanding its physiology, we reconstructed a genome-scale metabolic model, iJL1454, consisting 1454 genes, 1451 reactions 1155 metabolites, based on genome annotation literature mining. The model accurately predicted the growth phenotype A. different carbon nitrogen sources, after deletion essential genes. In 69 20 (a subset 69) genes were identified...
The principal pathology of Alzheimer's disease includes neuronal extracellular deposition amyloid-beta peptides and formation senile plaques, which in turn induce neuroinflammation the brain. Triptolide, a natural extract from vine-like herb Tripterygium wilfordii Hook F, has potent anti-inflammatory immunosuppressive efficacy. Therefore, we determined if triptolide can inhibit activation proliferation microglial cells astrocytes APP/PS1 double transgenic mouse model disease. We used 1 or 5...
Modelling across multiple scales is a current challenge in Systems Biology, especially when applied to multicellular organisms. In this paper we present an approach model at different spatial scales, using the new concept of hierarchically coloured Petri Nets (HCPN). We apply HCPN tissue comprising cells hexagonally packed honeycomb formation order describe phenomenon Planar Cell Polarity (PCP) signalling Drosophila wing. illustrate levels abstraction that can be used assist systematic...
Ethylene response factors have been shown to be involved in the effects of plant developmental processes and regulate stress tolerance. The aim this study was recognize regulatory mechanisms ethylene on tobacco height. In study, a gene-edited mutant (ERF10-KO) wild type (WT) were utilized as experimental materials. Transcriptome metabolome analyses used investigate mechanism NtERF10 gene editing height tobacco. Here, through analysis differentially expressed genes (DEGs), 2051 upregulated...
In this paper we describe a method and an associated computational tool to modify piecewise enlarge the topology of biological network model, using set biochemical components, in order generate one or more models whose behaviours simulate that target system. These components are defined as continuous Petri nets stored library for ease reuse. An optimization algorithm is proposed which exploits Simulated Annealing alter initial model by reference desired behaviour model.
Background: Previous data have suggested the involvement of circular RNA (circRNA) in ulcerative colitis (UC) development. However, role and mechanism circ_0085323 UC occurrence not been reported. Methods: Normal human colonic epithelial cells (NCM460) were treated with TNF-α to simulate UC-like cell inflammation injury vitro. The expression circ_0085323, microRNA-495-3p (miR-495-3p), TNF receptor-associated factor 3 (TRAF3) was detected by quantitative real-time polymerase chain reaction....
Systems biology aims to facilitate the understanding of complex interactions between components in biological systems. Petri nets (PN), and particular Coloured Nets (CPN) have been demonstrated be a suitable formalism for modelling systems building computational models over multiple spatial temporal scales. To explore high-dimensional solution space behaviours generated by such models, we propose clustering methodology which combines principal component analysis (PCA), distance similarity...
Potassium (K+) plays a role in enzyme activation, membrane transport, and osmotic regulation processes. An increase potassium content can significantly improve the elasticity combustibility of tobacco reduce harmful substances. Here, we report that expression analysis Nt GF14e, 14-3-3 gene, increased markedly after low-potassium treatment (LK). Then, chlorophyll content, POD activity were overexpression GF14e transgenic lines compared with those wild type plants. The net K+ efflux rates...
Enzymatic dephosphorylation-triggered self-assembly of DNA amphiphiles is developed by integrating enzymatic dephosphorylation-induced increase hydrophobicity and intermolecular aggregation lipid-conjugated oligonucleotides.