A5101661395- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Nuclear Receptors and Signaling
- Trigeminal Neuralgia and Treatments
- Facial Nerve Paralysis Treatment and Research
- Autophagy in Disease and Therapy
- Migraine and Headache Studies
- Lipid metabolism and disorders
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Healthcare and Venom Research
- Ferroptosis and cancer prognosis
- Calcium signaling and nucleotide metabolism
- COVID-19 and healthcare impacts
- Olfactory and Sensory Function Studies
- Infection Control and Ventilation
- Cancer Cells and Metastasis
- Berberine and alkaloids research
- Wireless Signal Modulation Classification
- Medical Research and Treatments
- Climate Change and Health Impacts
- Allergic Rhinitis and Sensitization
- Hormonal Regulation and Hypertension
- Atmospheric chemistry and aerosols
- Food Security and Health in Diverse Populations
Fudan University Shanghai Cancer Center
2025
Shanghai Medical College of Fudan University
2025
Shanghai Cancer Institute
2025
Fudan University
2020-2024
Zhongshan Hospital
2021-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Lanzhou University
2023
China National Center for Food Safety Risk Assessment
2021
Children's Hospital of Fudan University
2021
Abstract Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the pathogenesis atherosclerosis (AS). Our previous studies have demonstrated that apelin‐13/APJ confers proliferative response in VSMC, however, its underlying mechanism remains elusive. In this study, we aimed investigate role mitophagy apelin‐13‐induced VSMC and atherosclerotic lesions apolipoprotein E knockout (ApoE‐/‐) mice. Apelin‐13 enhances human aortic regulator proliferating cell...
Berberine (BBR) has a neuroprotective effect against ischemic stroke, but its specific protective mechanism not been clearly elaborated. This study explored the of BBR on canopy FGF signaling regulator 2 (CNPY2) pathway in penumbra rats. The model cerebral ischemia-reperfusion injury (CIRI) was established by thread embolization method, and gastrically perfused for 48 h or 24 before operation 6 after operation. rats were randomly divided into four groups: Sham group, CIRI + group. After...
Few studies have focused on the relationship between retail food environment and household supplies. This study examines spatial access to stores, shopping habits, nutrients available in supplies among 50 Mexican-origin families residing Texas border colonias.The design was cross-sectional; data were collected home March June 2010 by promotora-researchers. Ground-truthed methods enumerated traditional (supercenters, supermarkets, grocery stores), convenience (convenience stores marts),...
Background: Pancreatic ductal adenocarcinoma (PDAC) is notorious for its profoundly immunosuppressive nature. The complex crosstalk between diverse immune cell types and heterogeneous tumor populations shapes this challenging microenvironment (TIME). In study, the role of transmembrane BAX inhibitor motif-containing 1 (TMBIM1) in modulating TIME potential as a therapeutic target PDAC were investigated. Methods: RNA sequencing was used to assess differential gene expression PANC-1 cells with...
Apelin is the endogenous ligand for G protein-coupled receptor APJ. Both apelin and APJ are distributed in vascular smooth muscle cells (VSMCs) play important roles cardiovascular system. Our previous reports have indicated that apelin-13 promoted proliferation of VSMCs, but its exact mechanism remains to be further explored. The results present study demonstrated Warburg effect plays a pivotal role apelin-13-induced human aortic (HA-VSMCs) proliferation. Apelin-13 expression glucose...
<sec> <b>What is already known on this topic?</b> Aerosol transmission was one route for the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and usually occurred in confined spaces. </sec><sec> added by report?</b> found to exist between handshake buildings, i.e., buildings with extremely close proximity that formed relatively enclosed Transmission mainly affected airflow layout caused switching air conditioners off as well opening closing doors windows. are...
Background: The aims of this study are to estimate the disease burden allergic rhinitis (AR) patients and examine various underlying issues related symptoms services adult AR patients. Methods: Beijing hospital was picked as surveillance area, self-report questionnaires from data medical examinations by specialists otolaryngology were collected. with evaluated combined results patient-questionnaires specialist examination reports. Results: imposed a substantial on regarding everyday life...
Abstract Background Hemifacial spasm (HFS), a neuromuscular disorder affecting facial muscles, is commonly treated with microvascular decompression (MVD). This study aims to validate the HFS-5 grading questionnaire in assessing health-related quality of life improvements post-MVD. Methods A retrospective analysis was conducted on 147 out 239 HFS patients MVD from January 2018 December 2021. The used evaluate patients' before and after surgery. Statistical analyses included paired sample...
Affine Frequency Division Multiplexing (AFDM) is considered as a promising solution for next-generation wireless systems due to its satisfactory performance in high-mobility scenarios. By adjusting AFDM parameters match the multi-path delay and Doppler shift, can achieve two-dimensional time-frequency diversity gain. However, under fractional delay-Doppler channels, encounters energy dispersion affine domain, which poses significant challenges signal detection. This paper first investigates...
Objective To study the relationship of BDNF - TrkB signaling pathway and expression Arc in amygdala electrical stimulation kindled rats epilepsy.Methods Male SD were divided randomly into control group,sham group (simple kindling group,k252a injection group,DMSO group).Application Alpha Lab 4 channel signal acquisition processing system recording EEG activity rats.The level gene hippocampus was test by RT PCR hybridization,The protein immunohistochemistry.Results The V class insultus...
Objective The goal in this study is to investigate the microsurgical anatomy of relationship claustrum with its adjacent white matter fiber tracts,and analyze functional implications findings.Methods Ten formalin - fixed human brain hemispheres were dissected using Klingler dissection technique,with aid an operating microscope at 4 ～25 magnification.The claustrnm tracts was observed.Results Macroscopically,we divide into 2 parts:the dorsal and ventral claustrum,which humans...
Background: Ferroptosis is a novel form of regulated cell death that can inhibit the progression chemotherapy-resistant tumors. However, which types cancer derive greatest benefit from ferroptosis induction and role regulators in cancers (especially pancreatic cancer) remain unclear. Method: RNA sequencing data 31 were collected TCGA GTEx. Nomogram integrating patients’ clinical information risk score based on expression levels was depicted. The correlation between activity 29...
Abstract Background Human rhinovirus (HRV) is the predominant etiological agent of common cold in children and adults. A recent study showed that inhibitory effect face masks on viral shedding HRV was less prominent than other respiratory viruses. Considering most Chinese people have worn public area since outbreak coronavirus disease 2019, we aimed to find out whether prevailed among 2020 demonstrate details epidemiological features under such a special circumstance. Methods We summarized...