A5101991050- Retinal Diseases and Treatments
- Bone Metabolism and Diseases
- Inflammatory mediators and NSAID effects
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects of Natural Compounds
- Respiratory Support and Mechanisms
- Bone health and osteoporosis research
- RNA Interference and Gene Delivery
- Bone health and treatments
- Intraocular Surgery and Lenses
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- Retinal Imaging and Analysis
- Gastrointestinal motility and disorders
- Hepatitis B Virus Studies
- Peroxisome Proliferator-Activated Receptors
- Retinal and Macular Surgery
- Phytochemicals and Antioxidant Activities
- Receptor Mechanisms and Signaling
- Drug-Induced Hepatotoxicity and Protection
- Cardiac Imaging and Diagnostics
- Diet, Metabolism, and Disease
- Advanced biosensing and bioanalysis techniques
- Dialysis and Renal Disease Management
Heilongjiang Provincial Academy of Agricultural Sciences
2024
Inner Mongolia University
2015-2023
Guangdong Laboratory Animals Monitoring Institute
2022
Fudan University
2011-2021
Central South University
2009-2021
Huashan Hospital
2007-2021
Xiangya Hospital Central South University
2009-2021
Zhongshan Hospital
2004-2021
Sun Yat-sen University
2008-2021
The First Affiliated Hospital, Sun Yat-sen University
2008-2021
We conducted a cross-sectional survey including 23869 participants and aimed to measure the prevalences of risk factors for chronic kidney disease (CKD) diabetic (DKD) in Chinese rural population. CKD DKD status was defined according combination estimated glomerular filtration rate (eGFR) presence albuminuria Participant completed questionnaire involving life-style relevant medical history, blood urinary specimen were taken. The age- gender- adjusted calculated associated with analyzed by...
Abstract Background Spontaneous intracerebral hemorrhage (ICH) is a devastating form of stroke with the high mortality twofold to sixfold higher than that for ischemic stroke. But treatment haematomas within basal ganglia continues be matter debate among neurologists and neurosurgeons. The purpose this study judge short-term long-term clinical value minimally invasive stereotactic puncture therapy (MISPT) on acute ICH. Methods A prospective controlled was undertaken. trial in compliance WMA...
We explored the therapeutic effects of Dendrobium officinale polysaccharide (DOP) on CCl4-induced liver fibrosis with respect to intestinal hepatic axis using a rat model. Histopathological staining results showed that DOP alleviated extensive fibrous tissue proliferation in interstitium and lessened mucosal damage. Western blot PCR maintained balance by upregulating expression tight junction proteins such as occludin, claudin-1, ZO-1, Bcl-2 while downregulating Bax caspase-3 intestine. The...
Tumor microenvironment plays a vital role in the process of tumor development, proliferation, invasion, and metastasis. It is well acknowledged that reduction pH, reactive oxygen species (ROS), increased level glucose transporter 1 (GLUT1) have become featured intracellular extracellular biochemical markers cancer owing to oncogenic transformation abnormal metabolism. To establish distinctive drug delivery system directed against features, we develop newly engineered polymeric nanoplatform...
An ideal gene-carrying vector is supposed to exhibit outstanding gene-condensing capability with positively charged macromolecules protect the carried gene during in vivo circulation and a rapid dissociation upon microenvironmental stimuli at aimed sites release escorted gene. Currently, it still remains challenge develop an carrier efficient transfection ability low toxicity for clinical applications. Herein, we have innovatively introduced reactive oxygen species (ROS)-biodegradable boric...
Nonalcoholic fatty liver disease (NAFLD) is a common that currently has no standard treatment. The present study aimed to evaluate the effects of Lycium ruthenicum extract (LRE) on high‑fat diet (HFD)-induced NAFLD, and elucidate underlying molecular mechanisms. To determine hepatoprotective effect LRE, C57BL/6 mice were fed normal control diet, (HFD), HFD supplemented with 2 g/kg or 5 LRE. Treatment LRE markedly decreased levels triglycerides, total cholesterol, aspartate aminotransferase...
Summary Aims The damage of human brain vascular endothelial cells ( HBVEC s) is the key pathogenesis diabetes‐associated cerebral complications. aim this study was to elucidate effects glutathione GSH ) on free fatty acids FFA s)‐induced s apoptosis, oxidative stress, and involved possible signaling pathway. Methods After culturing for 72 h with s, we determined cell proliferation by CCK 8, detected apoptosis caspase‐3 A nnexin V ‐ FITC / PI staining, judged oxygen stress determining...
This study aims to comprehensively investigate the effects of hot-air dehydration on quality blue honeysuckle berries (
Exploring the genetic aberrations favoring metastasis is important for understanding and developing novel strategies to combat cancer metastasis. It remains lack of effective treatment dismal prognosis intrahepatic cholangiocarcinoma (ICC). Here, we aimed study alternations during lymph node ICC investigate potential mechanisms clinical strategy focused on mutations. We performed whole‐exome sequencing transcriptome samples from 30 patients, including metastases five patients. identified...
Objective . Oxidant stress plays an important role in the development of diabetic cardiomyopathy. Previously we reported that Astragalus polysaccharides (APS) rescued heart dysfunction and cardinal pathological abnormalities mice. In current study, determined whether effect APS on cardiomyopathy was associated with its impact oxidant stress. Methods Db/db mice were employed administered APS. The hematodynamics, cardiac ultra-structure, apoptosis, ROS formation myocardium assessed. protein...
Most small molecular chemotherapeutics have poor water solubility and unexpected pharmacokinetics toxicity to normal tissues. A series of nano drug delivery systems been developed solve the problems, among which a micelle based on linear-dendritic polymer-drug conjugates (LDPDCs) is promising strategy deliver hydrophobic due its size, fine stability in blood circulation, high loading capacity. In this work we synthesized novel amphiphilic PEG-PTX8 conjugate can also encapsulate extra free...
Reports of choroidal and retinal changes before after haemodialysis are few have been controversial. Traditional imaging modalities insufficient for quantitative assessment. This study aims to use optical coherence tomography angiography monitor the short-term vascular density thickness in retina choroid haemodialysis.Seventy-seven eyes 77 patients with end-stage kidney disease undergoing were included. Ophthalmologic examinations including performed one hour haemodialysis. The measured...
Medication adherence is crucial for decreasing the burden of tuberculosis, but few relevant studies have been conducted in northeast China. This study aimed to explore level medication among pulmonary tuberculosis outpatients and predictive factors based on bio-psycho-social medical model.A cross-sectional multi-center survey was four institutions Dalian, measured using eight-item Chinese version Morisky Adherence Scale, which divides into three levels. The independent variables consisted...
Single nucleotide polymorphisms (SNPs) of HLA-DQ and granulysin (GNLY) are reportedly associated with HBV infection. The aim this study was to investigate the effects interactions between SNPs in GNLY on outcome hepatitis B virus (HBV) infection Chinese Han subjects. (rs9275572) (rs1866139 rs11127) were genotyped 310 subjects HBV-related chronic liver disease, 295 whom spontaneous clearance had occurred 316 who not been exposed HBV. rs9275572 significantly correlated (dominant genetic model:...
To evaluate the relationships between C-reactive protein (CRP) and retinal choroidal thickness by swept-source optical coherence tomography (SS-OCT). The participants included in prospective cross-sectional study underwent a comprehensive ophthalmic examination. Based on CRP values, subjects were divided into (+) group (CRP ≥ 8.2 mg/L) (-) < mg/L). was compared two groups. This enrolled 43 right eyes of from 86 gender- age-match group. thinner than that except for outer nasal sector Early...
It is unclear how alterations in gray matter volume and white density affect elderly patients with irritable bowel syndrome (IBS). This study aimed to investigate the relationship between structural changes brain psychological stress IBS patients.Eighteen 12 healthy controls underwent magnetic resonance imaging. Voxel-based morphometry diffusion tensor imaging analysis were used identify abnormalities cortical regions matter, respectively.The group showed a significant GMV reduction...
Coxsackievirus A2 (CVA2) has emerged as an active pathogen that been implicated in hand, foot, and mouth disease (HFMD) herpangina outbreaks worldwide. It reported severe cases with CVA2 infection develop into heart injury, which may be one of the causes death. However, mechanisms CVA2-induced injury have not well understood. In this study, we used a neonatal mouse model to investigate possible injury. We detected replication apoptosis tissues from infected mice. The activity total aspartate...
Mutations in the gene of connexin 26 (Cx26) are most common cause human non‑syndromic hereditary deafness. The pathogenesis deafness caused by Cx26 remains uncertain. To explore basic mechanism underlying null mutations, ultrastructural changes and a number marker proteins cochlear sensory epithelium conditional knockout mice were observed current study. Cochlear specimens obtained from (cCx26ko), while wild‑type served as controls. Antibodies against pillar cell P75, supporting prox1 hair...
Purpose . To assess whether to continue aspirin therapy while having uncomplicated phacoemulsification cataract surgery with different incisions. Methods Consecutive patients under topical anesthesia incisions between May 2016 and August 2017 were followed. 236 eyes of 166 on routine randomized into 2 groups: continuation group, 112 eyes; discontinuation 124 eyes. 121 94 no anticoagulant used as the control group. Patients examined 1 day preoperatively 7 days postoperatively. Intraoperative...