A5100400604- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Lipid metabolism and disorders
- Lipoproteins and Cardiovascular Health
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Protease and Inhibitor Mechanisms
- Cardiomyopathy and Myosin Studies
- Kruppel-like factors research
- Advanced MRI Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroscience and Neural Engineering
- Knee injuries and reconstruction techniques
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cardiac Ischemia and Reperfusion
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
Qilu Hospital of Shandong University
2016-2025
Affiliated Hospital of Jining Medical University
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Shandong University
2007-2024
Beijing YouAn Hospital
2024
Capital Medical University
2006-2024
Macau University of Science and Technology
2023
Guiyang Medical University
2023
Minjiang University
2023
Virtual Reality Medical Center
2023
Background: Computed tomography–derived fractional flow reserve (CT-FFR) using on-site machine learning enables identification of both the presence coronary artery disease and vessel-specific ischemia. However, it is unclear whether CT-FFR improves clinical or economic outcomes when compared with standard care in patients stable disease. Methods: In total, 1216 an intermediate stenosis 30% to 90% on computed tomographic angiography were randomized pathway 6 Chinese medical centers. The...
The mechanism by which hyperuricemia induced-endothelial dysfunction contributes to cardiovascular diseases (CVDs) is not yet fully understood. In the present study, we used uric acid (UA) trigger endothelial in cultured cells, and investigated effects of induced reactive oxygen species (ROS) generation, endoplasmic reticulum (ER) stress induction, protein kinase C (PKC)-dependent nitric oxide synthase (eNOS) signaling pathway. Human umbilical vein cells (HUVECs) were incubated with 6, 9 or...
Purpose Ongoing Monkeypox (MPX) outbreaks in countries outside Africa have unique characteristics. However, data on cohorts of confirmed cases China is limited. The study provides important epidemiological, diagnostic, and clinical information about this disease China. Methods We report a series Chinese individuals with MPX infections identified at Beijing Youan Hospital (China) from June 10 to July 15, 2023. Samples were taken the skin, anus, throat, blood. An epidemiological questionnaire...
BACKGROUND: Many cardiovascular pathologies are induced by signaling through G-protein-coupled receptors via Gsα (G protein stimulatory α subunit) proteins. However, the specific cellular mechanisms that driven and contribute to development of atherosclerosis remain unclear. METHODS: High-throughput screening involving data from single-cell bulk sequencing were used explore expression in atherosclerosis. The differentially activity analyzed immunofluorescence cAMP measurements....
Abstract —Inherited mutations and a polymorphism in minK-related peptide 1 (MiRP1) have been linked to congenital or acquired long-QT syndrome, pointing the importance of MiRP1 maintaining cardiac electrical stability. We tested whether could affect function Kv4.x (x=2 3), major pore-forming (α) subunits transient outward ( I ) channels heart. used Xenopus oocyte expression system examine effects on channel gating kinetics current amplitude correlated these with level. slowed rates Kv4.2...
Atherosclerotic plaque rupture and thrombosis are the main cause of acute coronary syndrome. The study was aimed to test hypothesis that oral administration rapamycin may attenuate inflammation, inhibit progression enhance stability atherosclerotic plaques.Thirty New Zealand rabbits were subjected balloon-induced endothelial injury abdominal aorta fed a diet 1% cholesterol for 20 weeks. From week 9 20, animals treated with (0.5 mg x kg(-1) day(-1); group A), simvastatin (5 B) no drugs (group...
We aimed to investigate the clinical and genetic features of paroxysmal kinesigenic dyskinesia (PKD) in a large population analyze genotype-phenotype correlation PKD.We analyzed manifestations conducted PRRT2 screening 110 patients with PKD. Clinical data were compared between 91 probands without mutations.Among enrolled participants (45 from 26 families, 65 sporadic cases), 8 mutations detected 20 PKD families (76.9%) 14 cases (21.5%), accounting for 37.4% (34/91) study population. Five...
Abstract Several clinical studies reported that Dickkopf1 (DKK1) plasma levels are correlated with atherosclerosis. However, the impact of DKK1 on formation and vulnerability atherosclerotic plaques remains elusive. This study investigated DKK1’s effects enlargement destabilization by targeting endothelial cells assessing possible cellular mechanisms involved. The atherogenesis plaque stability were evaluated in ApoE−/− mice using lentivirus injections to knockdown knock-in gene. presence...
Purpose. Pterygia are histologically composed of proliferating fibrovascular tissue. This study compared expression levels an angiogenic inhibitor, pigment epithelium-derived factor (PEDF), in pterygia with those normal corneal and conjunctival tissues. Methods. The human tissues were obtained from surgery or donor eyes without ocular diseases. excised by therapeutic under a microscope. Pigment vascular endothelial growth (VEGF) measured Western blot analysis. Their cellular localizations...
C-type inactivation in the HERG channel is unique among voltage-gated K channels having extremely fast kinetics and strong voltage sensitivity. This suggests that may have a outer mouth structure (where conformational changes underlie inactivation), and/or communication between sensor. We use cysteine-scanning mutagenesis thiol-modifying reagents to probe structural functional role of S5-P (residues 571–613) P-S6 631–638) linkers line vestibule channel. Disulfide formation involving...
Elbow contractures, a frequent problem after injury, can be treated by excision of the joint capsule. However, underlying changes in capsule are poorly understood. Based on skin healing work, we examined hypotheses that myofibroblast numbers and expression marker α-smooth muscle actin, elevated patients with posttraumatic contractures. Anterior capsules were obtained from six who had operative release contractures greater than 5 months injury elbows organ donors free Immunohistochemical...
Low testosterone levels is associated with higher cardiovascular risk in men diabetes. However, there are few studies on and the factors affecting them patients young-onset diabetes (YOD). The objective of this study was to investigate correlation between waist-to-hip ratio (WHR) diagnosed YOD. This cross-sectional involved 547 male type 2 mellitus (T2DM) from Endocrinology Department Affiliated Hospital Jining Medical University. participants were divided into two groups: a (YOD) group...
BACKGROUND: The hyperproliferation of smooth muscle cells and deposition collagen in the pulmonary artery are among primary characteristics hypertension (PH). These processes contribute to vascular remodeling, ultimately leading elevated pressure right ventricular failure. MrgD (Mas-related G-protein–coupled receptor member D) exhibits close associations with certain cardiovascular diseases; however, its role PH remains unclear. METHODS: effects absence or activation on were investigated...
Background and purpose A recently developed animal model of posttraumatic contractures reflects the chronic stages human condition. To understand initiation process, we evaluated cellular, matrix, growth factor changes in joint capsule early model, which would not be possible humans.Methods 18 skeletally mature rabbits had intraar-ticular cortical windows removed from medial lateral femoral condyles, knee was immobilized. The contralateral unoperated limb served as a control. Equal numbers...
Abstract To determine whether the traditional Chinese medicine Tongxinluo (TXL) is efficacious at retarding progression of carotid atherosclerotic lesions, a total 1,212 patients with focal intima-media thickness (IMT) ≥1.2 mm arteries received TXL or placebo capsules in addition to current routine therapy. The primary outcome was between-group differences annualized change mean IMT 12 sites bilateral over 24 months. secondary outcomes were plaque area, vascular remodeling index (RI), serum...
The joint capsule is a key component in posttraumatic contractures. described as thickened, but little data exist supporting the observation. Our hypotheses were that mRNA levels of (1) collagen; (2) decorin and biglycan; (3) matrix metalloproteinases; (4) tissue inhibitors metalloproteinases significantly elevated anterior capsules obtained from 11 patients having surgery for contractures when compared with nine elbows, organ donors, free Reverse transcription-polymerase chain reaction was...