A5059685048- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- MRI in cancer diagnosis
- Venous Thromboembolism Diagnosis and Management
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Cardiovascular Health and Disease Prevention
- Ultrasound in Clinical Applications
- Cardiac Valve Diseases and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiac, Anesthesia and Surgical Outcomes
- Circular RNAs in diseases
- Blood Coagulation and Thrombosis Mechanisms
- MicroRNA in disease regulation
- Cardiovascular Effects of Exercise
- Atherosclerosis and Cardiovascular Diseases
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Health and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
Chinese PLA General Hospital
2017-2025
Chinese People's Liberation Army
2023
Chinese General Hospital College of Nursing and Liberal Arts
2023
Harvard University
2019
Second Military Medical University
2014
Changhai Hospital
2014
Background: Computed tomography–derived fractional flow reserve (CT-FFR) using on-site machine learning enables identification of both the presence coronary artery disease and vessel-specific ischemia. However, it is unclear whether CT-FFR improves clinical or economic outcomes when compared with standard care in patients stable disease. Methods: In total, 1216 an intermediate stenosis 30% to 90% on computed tomographic angiography were randomized pathway 6 Chinese medical centers. The...
The perivascular fat attenuation index (FAI) evaluated by coronary computed tomographic angiography (CCTA) has been reported to have strong prognostic value, but few studies focused on young people. This study aimed assess the predictive value of FAI in people suspected having atherosclerotic disease (CAD). A retrospective analysis was performed adults aged ≤ 45 years who underwent CCTA due CAD between 2015 and 2016 were followed up for at least 5 following their visit (n = 503). proximal...
Purpose To investigate whether pericoronary adipose tissue attenuation (PCATa) provides incremental prognostic value over commonly used coronary CT angiography (CCTA) parameters for predicting major adverse cardiovascular and cerebrovascular events (MACCE) in individuals with diabetes mellitus (DM). Materials Methods This prospective study included consecutive patients type 2 DM who underwent CCTA due to suspected artery disease between January 2015 December 2017. PCATa of three arteries was...
Background Coronary Artery Disease Reporting and Data System (CAD-RADS) was developed to standardize optimize disease management in patients after coronary CT angiography (CCTA), but the impact of CAD-RADS recommendations on clinical outcomes remains unclear. Purpose To retrospectively assess association between appropriateness post-CCTA according version 2.0 outcomes. Materials Methods From January 2016 2018, consecutive participants with stable chest pain referred for CCTA were...
Oxidative stress may play a crucial role in cardiac and vascular abnormalities different types of cardiovascular diseases. In the present study, we explored mechanism underlying oxidative stress-mediated cardiomyocyte apoptosis with focus on Akt-p53 signaling pathway. vitro, was cultured concentrations hydrogen peroxide. Then, viability, rate pathway were analyzed through ELISA, immunofluorescence, qPCR western blots. The results indicated that caused dose-dependent manner. Mechanistically,...
Objective: To evaluate the diagnostic performance of automated quantitative analysis by coronary computed tomography angiography (CCTA) in identifying lesion-specific hemodynamic abnormality. Methods: A total 132 patients (mean age, 61 y; 86 men) with 169 vessels (with 30% to 90% diameter stenosis), who successively underwent invasive evaluation fractional flow reserve (values ≤0.8 were defined as abnormalities), analyzed CCTA. CCTA images quantitatively using software obtain following...
Objective . To explore the association between EAT volume and plaque precise composition high risk detected by coronary computed tomography angiography (CCTA). Methods 101 patients with suspected artery disease (CAD) underwent CCTA examination from March to July 2019 were enrolled, including 70 cases acute syndrome (ACS) 31 stable angina pectoris (SAP). Based on image, atherosclerotic compositions analyzed using dedicated quantitative software. High was defined as more than 2 features...
Abstract Background Coronary computed tomography angiography (CCTA)-derived fractional flow reserve (CT-FFR) enables physiological assessment and risk stratification, which is of significance in diabetic patients with nonobstructive coronary artery disease (CAD). We aim to evaluate prognostic value the global trans-lesional CT-FFR gradient (GΔCT-FFR), a novel metric, diabetes without flow-limiting stenosis. Methods Patients suspected having CAD were prospectively enrolled. GΔCT-FFR was...
The coronary artery calcification score and pericardial fat volume have recently been reported to be strongly associated with the severity presence of atherosclerosis. However, no studies explored outcome phased progression atherosclerosis by non-contrast computed tomography in asymptomatic people China. population-based cohort study China (PERSUADE), an observational, longitudinal prospective a target population healthy subjects based Jidong Oilfield (China), prospectively analyzes...
Abstract Background The diagnostic accuracy of CT-derived fractional flow reserve (CT-FFR) in clinical application has been well validated. This advanced technology focus on evaluating anatomical stenosis and functional ischemia simultaneously. However, the effect CT-FFR management decision making not fully evaluated randomized controlled design. Method/design TARGET study is a pragmatic, multicenter, prospective, open-label, trial CCTA/CT-FFR strategy (group A) versus usual care B)...
Evidence supports the efficacy of coronary computed tomography angiography (CCTA)-based risk scores in cardiovascular stratification patients with suspected artery disease (CAD). We aimed to compare two CCTA-based score algorithms, Leiden and Confirm scores, diabetes mellitus (DM) CAD.This single-center prospective cohort study consecutively included 1241 DM (54.1% male, 60.2 ± 10.4 years) referred for CCTA CAD 2015-2017. were calculated stratified as < 5 (reference), 5-20, > 20 14.3...
We can use several noninvasive cardiac imaging modalities in the diagnosis of coronary artery disease (CAD), and we have investigated these technologies many clinical trials. Some already become regular examinations assessment CAD among large-scale hospitals. detect not only anatomic stenosis but also functional myocardial ischemia according to information provided by methods. Based on evaluation versatile modalities, risk stratification treatment management help improve prognosis patients...
Subclinical hypothyroidism (SCH) has recently been acknowledged as an unconventional risk factor for coronary artery disease (CAD) and characterized by poor prognosis, which may be due to atherosclerotic plaque characteristics. We conducted this study observe characteristics in patients with concomitant SCH.Patients were enrolled the divided into SCH group (patients, n = 26; plaques, 35) a non-SCH 52; 66). They 1: 2 according propensity-matched analysis including age, diabetes mellitus,...
To evaluate the feasibility and tolerability of metoprolol standard dosing pathway (MSDP) in Chinese patients with acute coronary syndrome (ACS).In this multicenter, prospective, open label, single-arm interventional study that was conducted from February 2018 to April 2019 fifteen hospitals. A total 998 hospitalized aged ≥ 18 years diagnosed ACS were included. The MSDP applied all eligible based on treatment recommended by international guidelines. primary endpoint percentage achieving...
Background and purpose: The effectiveness of low-density lipoprotein cholesterol (LDL-C) lowering therapy in patients with higher baseline LDL-C levels has been extensively studied Western populations. However, it remains uncertain whether the standard low-to-moderate lipid-lowering practiced Chinese individuals can lead to coronary plaque regression. Our objective is explore connections between regression/stabilization, levels, extent reduction. Methods: This study constitutes a post hoc...
The prognostic impact of non-obstructive coronary artery disease (CAD) has long been underestimated due to its mild stenosis (<50% stenosis). We aim investigate the value atherosclerotic extent in DM patients with CAD.The analysis was based on a single center cohort referred for computed tomography angiography (CCTA) suspect CAD 2015-2017. Based combined segment involvement score (SIS), study population were divided into four groups: normal (0% stenosis), SIS<3, SIS≥3 and obstructive (≥50%...
Lipoprotein(a) [Lp(a)] has been closely related to coronary atherosclerosis and might affect perivascular inflammation due its proinflammatory properties. However, there are limited data about Lp(a) on atheroma progression. Therefore, this study aimed investigate the associations between fat attenuation index (FAI) with progression detected by computed tomography angiography (CCTA).Patients who underwent serial CCTA examinations without a history of revascularization available for within one...
Objective: To characterize the hemodynamic force towards coronary plaque based on noninvasive computed tomographic angiography and to investigate its relationship with features stenosis severity by computational fluid dynamics. Methods: Twenty-six patients underwent invasive fractional flow reserve measurement following tomography examination from March September 2016 were retrospectively included. Computational dynamics was applied wall shear stress (WSS) axial (APS), which extracted...