A5057610664- Acute Myocardial Infarction Research
- Metabolomics and Mass Spectrometry Studies
- Cardiac Ischemia and Reperfusion
- Liver Disease Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Coronary Interventions and Diagnostics
- Cancer-related molecular mechanisms research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Hormonal Regulation and Hypertension
- Cancer-related cognitive impairment studies
- Fatty Acid Research and Health
- Circular RNAs in diseases
- Atrial Fibrillation Management and Outcomes
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Cardiac Fibrosis and Remodeling
- Eicosanoids and Hypertension Pharmacology
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Pickering emulsions and particle stabilization
Qingdao University
2016-2025
Affiliated Hospital of Qingdao University
2016-2025
Diabetic cardiomyopathy (DCM), an independent coronary heart disease that develops in diabetic individuals, is characterized by changes the myocardial structure and function. The aim of present study was to investigate protective effect rutin on DCM a streptozotocin‑induced rat model. Rutin orally administrated at dose 8 mg/kg body weight. Metabolic profiles, enzymes oxidative stress were examined biochemical tests. expression levels cellular proteins associated with apoptosis measured...
Long non-coding RNAs (lncRNAs) play a crucial role in the growth of vascular smooth muscle cells (VSMCs), dysfunction which is closely associated with initiation and progression cardiovascular diseases (CVDs). Abnormal phenotypic switching proliferation VSMCs constitute significant event atherosclerosis. The present study identified novel lncRNA, PEBP1P2, serves as valuable regulator transformation proliferation. expression PEBP1P2 was remarkably decreased proliferating pathological arteries...
Estrogen significantly impacts women’s health, and postmenopausal hypertension is a common issue characterized by blood pressure fluctuations. Current control strategies for this condition are limited in efficacy, necessitating further research into the underlying mechanisms. Although metabolomics has been applied to study various diseases, its use understanding scarce. Therefore, an ovariectomized rat model was used simulate conditions. levels, pressure, aortic tissue were analyzed. Animal...
Purpose: This study is aimed at identifying clinical and echocardiographic factors associated with all‐cause mortality or heart transplantation (HTx) in young patients dilated cardiomyopathy (DCM). Methods: We conducted a retrospective analysis of hospitalized (aged 18–45 years) diagnosed DCM between January 2012 December 2022. All underwent 2‐year medical therapy for failure, followed by least 1 year follow‐up. Clinical data were collected baseline after the treatment period. Multivariate...
Objective The number of deaths from heart disease is increasing worldwide. Aflatoxin B1 (AFB1), a toxin produced by the fungi Aspergillus flavus and parasiticus, frequently detected in improperly processed/stored human food products. While AFB1 hepatotoxicity carcinogenic properties have been well addressed, its myocardial toxicity poorly documented. This study aimed to investigate toxic activity AFB1. Methods Ten rats were fed with at dose that did not result acute reactions for 30 days 10...
Abstract Drug-eluting stents are a commonly used treatment for coronary artery disease. However, the coatings in drug-eluting have some limitations such as poor biocompatibility and drug loading capacity. In recent years, self-assembly methods emerged promising alternative stent coatings. Self-assembled employ biomaterials offer several advantages over traditional coatings, including thinner thickness, stronger binding capacity, better biocompatibility. This review discusses latest research...
Abstract Background Diabetes mellitus is one of the causes poor ventricular remodelling and cardiac recovery after myocardial infarction (MI). We previously reported that tissue factor pathway inhibitor-2 (TFPI2) was downregulated in response to hyperglycaemia it played a pivotal role extracellular matrix (ECM) degradation cell migration. Nonetheless, function mechanism TFPI2 post-MI under diabetic conditions remain unclear. Therefore, present study, we investigated effects mouse model....
Hypertension is a universal risk factor for variety of cardiovascular diseases. Investigation the mechanism hypertension will benefit around 40% world's adult population. MicroRNA crucial initiation and progression In this study, angiotensin II-treated human umbilical vein endothelial cells were used as model to imitate pathological changes in under hypertensive conditions. We demonstrated that microRNA-9 (miR-9) suppressed II-induced apoptosis enhanced proliferation cells. Direct...
Aim: To observe if personalized antiplatelet therapy according to the CYP2C19 phenotype can improve outcomes of patients receiving selective percutaneous coronary intervention (PCI). Methods: In this observational study, 677 Chinese undergoing PCI were divided into gene group (n = 369) and conventional 308), given genotype or clinical features, respectively. Incidence MACE (death, non-fatal myocardial infarction, unplanned repeat revascularization) bleeding was compared between two groups...
The aim of the present study was to examine post-infarct acute effect adenosine-5'-triphosphate (ATP) on myocardial infarction (MI) size as well its precise molecular mechanism. Sixty New Zealand white male rabbits were exposed 40 min ischemia followed by 180 reperfusion. intravenously administered 3 mg/kg ATP (ATP group) or saline (control immediately after reperfusion and maintained throughout first 30 min. wortmannin+ATP, PD-98059+ATP, 5-hydroxydecanoic acid (5-HD) sodium salt+ATP groups...
Abstract Background The diabetic heart exhibits a high sensitivity to ischaemia/reperfusion (I/R) injury. Diabetes mellitus (DM) can affect the efficacy of cardioprotective interventions and reduce therapeutic potential existing treatment options. This study aimed investigate feasibility shifting from monotherapy combination therapy in myocardial I/R Methods 6–8 week rats were randomized into 10 groups: sham, I/R, ischaemia postconditioning (I-Post), nicorandil (Nic), (I-Post + Nic), DM...
Abstract Background Left ventricular thrombus (LVT) is a serious complication after myocardial infarction. However, due to its asymptomatic nature, early detection challenging. We aimed explore the differences in clinical correlates of LVT found acute subacute and chronic phases Methods collected data from 153 patients who were diagnosed with infarction at Affiliated Hospital Qingdao University January 2013 December 2022. Baseline information, inflammatory markers, transthoracic...
Abstract Background Estrogen significantly impacts women’s health, and postmenopausal hypertension is a common issue characterized by blood pressure fluctuations. Current control strategies for this condition are limited in efficacy, necessitating further research into the underlying mechanisms. Although metabolomics has been applied to study various diseases, its use understanding scarce. Methods An ovariectomized rat model was used simulate conditions. levels, pressure, aortic tissue were...
<title>Abstract</title> Background Niacin, also known as vitamin B3 or nicotinic acid (NA), exhibits beneficial effects on factors influencing the decline of kidney function. In chronic disease (CKD) patients, relationship between dietary niacin and mortality prognosis remains unclear. Methods The study involved 2,962 CKD patients from National Health Nutrition Examination Survey (NHANES) 2005 to 2018 followed for survival through December 31, 2019. Cox proportional hazards models were...
Purpose: Doxorubicin-induced cardiotoxicity (DIC) is a severe side reaction in cancer chemotherapy that greatly impacts the wellbeing of patients.Currently, there still an insufficiency effective and reliable biomarkers field clinical practice for early detection DIC.This study aimed to determine validate potential diagnostic predictive values critical signatures DIC.Methods: We obtained high-throughput sequencing data from GEO database performed analysis visualization using R software, GO,...
Abstract Background Insomnia, as one of the most prevalent sleep disorders, is frequently linked to Heart failure (HF). However, precise relationship and potential risk HF events associated with insomnia subtypes symptoms necessitate further investigation. Objective This updated meta-analysis aimed evaluate associations between various symptoms, including difficulty initiating (DIS), maintaining (DMS), early-morning awakening (EMA) non-restorative (NRS). Methods A comprehensive literature...
Estrogen significantly impacts women's health, and postmenopausal hypertension is a common issue characterized by blood pressure fluctuations. Current control strategies for this condition are limited in efficacy, necessitating further research into the underlying mechanisms. Although metabolomics has been applied to study various diseases, its use understanding scarce. Therefore, an ovariectomized rat model was used simulate conditions. levels, pressure, aortic tissue were analyzed. Animal...