A5000753033- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Organ Transplantation Techniques and Outcomes
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Erythrocyte Function and Pathophysiology
- Clinical Nutrition and Gastroenterology
- Virus-based gene therapy research
- Congenital Heart Disease Studies
- Esophageal and GI Pathology
- Liver Disease and Transplantation
- RNA modifications and cancer
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Blood groups and transfusion
- Wound Healing and Treatments
- Neonatal Health and Biochemistry
- Esophageal Cancer Research and Treatment
- TGF-β signaling in diseases
- S100 Proteins and Annexins
- Medical Imaging and Pathology Studies
- Immune Response and Inflammation
- Signaling Pathways in Disease
Ruijin Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Shanghai Institute of Hematology
2023-2025
Qingdao University
2014-2024
Affiliated Hospital of Qingdao University
2019-2024
Duke-NUS Medical School
2019
Taizhou Central Hospital
2017
Nanyang Technological University
2016
Qingdao Municipal Hospital
2014
Qilu Hospital of Shandong University
2014
Background: Transforming growth factor β1 (TGFβ1) was one of the main factors for accelerating atrial fibrosis and has been reported with significantly higher level in plasma patients essential hypertension (EH), especially those target organ damage. The contribution TGFβ1 pathogenesis fibrillation (AF) EH remains unknown. Methods: 75 documented AF were divided into paroxysmal group (EH+pAF, n = 44) or chronic (EH+cAF, 31), 37 sinus rhythm (SR) assigned EH+SR group. All data including...
Abstract Background Diabetes mellitus is one of the causes poor ventricular remodelling and cardiac recovery after myocardial infarction (MI). We previously reported that tissue factor pathway inhibitor-2 (TFPI2) was downregulated in response to hyperglycaemia it played a pivotal role extracellular matrix (ECM) degradation cell migration. Nonetheless, function mechanism TFPI2 post-MI under diabetic conditions remain unclear. Therefore, present study, we investigated effects mouse model....
Diabetes mellitus significantly escalates the risk of accelerated atherosclerosis (AS), severely affecting cardiovascular health. Our research, leveraging Gene Expression Omnibus (GEO) database analysis (GSE118481), revealed diminished TFPI2 expression in diabetic patients' atherosclerotic plaques. Further validation carotid artery plaques and an AS mouse model confirmed TFPI2's reduced diabetes. Through knockdown non-diabetic mice, we observed aggravated plaque burden increased inflammatory...
Abstract Neural-Wiskott Aldrich Syndrome Protein (N-WASP) is expressed ubiquitously, regulates actin polymerization and essential during mouse development. We have previously shown that N-WASP critical for cell-ECM adhesion in fibroblasts. To characterize the role of fibroblast skin development, we generated a conditional knockout model which was ablated using Cre recombinase driven by Fibroblast Specific promoter (Fsp-Cre). FKO ( fl/fl ; Fsp-cre ) were born following Mendelian genetics,...
Hypertension is a universal risk factor for variety of cardiovascular diseases. Investigation the mechanism hypertension will benefit around 40% world's adult population. MicroRNA crucial initiation and progression In this study, angiotensin II-treated human umbilical vein endothelial cells were used as model to imitate pathological changes in under hypertensive conditions. We demonstrated that microRNA-9 (miR-9) suppressed II-induced apoptosis enhanced proliferation cells. Direct...
The present study aimed to investigate the therapeutic efficacy and clinical value of recombinant human adenovirus-p53 (rAd-p53) perfusion via pancreatic artery for treatment mid-late stage cancer. rAd-p53 (2×1012 virus particles) in 6 ml normal saline was pushed (intravenous bolus) into gastroduodenal superior pancreaticoduodenal arteries interventional superselection, with catheter retained subsequent drug administration at a 3-day interval 4 cycles. Tumor changes all patients were...
Abstract Li-Fraumeni syndrome (LFS) is characterized by germline mutations occurring on one allele of genome guardian TP53 . It a severe cancer predisposition with poor prognosis, partly due to the frequent development subsequent primary tumors following DNA-damaging therapies. Here we explored, for first time, effectiveness mutant p53 rescue compound in treating LFS-mimicking mice harboring deleterious mutation. Among ten hotspot IARC LFS cohorts, R282W predicting poorest survival prognosis...
Objectives. To study trends of utilization, in-hospital outcomes, and short outcomes in patients undergoing transcatheter mitral valve repair (TMVR) vs. surgical (SMVR) atrial fibrillation (AF). Background. TMVR is a treatment option inoperable or high-risk with regurgitation (MR). AF common comorbidity MR. Data comparing between SMVR MR lacking. Methods. The National Readmission Database from 2016 to 2019 was utilized identify hospitalizations AF. Outcomes interest included mortality,...
To the editor: Pulmonary sequestration is an uncommon congenital anomaly in which arterial supply derives most frequently from thoracic or abdominal aorta and other origins of blood are rarely described. Here we report a patient with pulmonary originating right coronary artery (RCA). A 54-year-old male complained recurring slight chest pain occasional feeling palpitation. In his medical history there was notable episode hemoptysis at age 38 years, for he had been suspected suffering...
Objective To judge the prognosis of adult recipients after first liver transplantation by stepwise discriminant analysis,and screen out main influencing factors.Methods The clinical data 221 patients who received at Nanfang Hospital Southern Medical University were retrospectively analyzed.A total 218 met criteria divided into training samples (188 admitted from August 2004 to June 2010) and checking (30 July 2010 February 2011),and then all re-divided dead group (survival time ≤ 90 days,34...
Objective To investigate the risk factors of severe intrahepatic cholestasis during early period after liver transplantation.Methods The clinical data 225 patients who received orthotopic transplantation at Nanfang Hospital Southern Medical University from August 2004 to February 2011 were retrospectively analyzed.All divided into positive group (60 with cholestasis) and negative (165 without cholestasis).Preoperative,intraoperative postoperative 2 groups compared via t test,chi-square...
Objective To study the expression of cyclooxygenase-2,epithelial cadherin and vascular endothelial growth factor-c in colorectal cancer its significance. Methods Seventy-seven patients with were detected COX-2, E-ca nd VEGF-c by immunohistochemical SP method. Results COX-2 positive tissue was 24.7%; rate 68.8%; 84.4%. highly differentiated tissues significantly higher than poorly ones (P ＜0. 05); tubular adenocarcinoma mucous glands other types ( P ＜ 0. 05 ); The Positive stage Ⅰ + Ⅱ Ⅲ Ⅳ...