A5112359857- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- Medicinal Plants and Bioactive Compounds
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Epigenetics and DNA Methylation
- Virus-based gene therapy research
- Genomics, phytochemicals, and oxidative stress
- Plant nutrient uptake and metabolism
- Essential Oils and Antimicrobial Activity
- Biochemical and biochemical processes
- Cancer, Hypoxia, and Metabolism
- Food Safety and Hygiene
- Single-cell and spatial transcriptomics
- Cholesterol and Lipid Metabolism
- Food Supply Chain Traceability
- Trace Elements in Health
- Isotope Analysis in Ecology
- Arsenic contamination and mitigation
- Cancer Cells and Metastasis
- Biological and pharmacological studies of plants
Shanghai Institute of Hematology
2019-2025
Ruijin Hospital
2020-2025
Shanghai Jiao Tong University
2019-2025
Nanjing University of Aeronautics and Astronautics
2025
Ministry of Agriculture and Rural Affairs
2018-2020
Zhejiang University
2018-2020
Ningbo University
2020
Northwest A&F University
2019
Arabidopsis calcium-dependent protein kinase CPK6 positively regulates seed germination, seedling growth, and drought tolerance via phosphorylating ABF ABI5 transcription factors.
Tumor suppressor p53 is inactivated by thousands of heterogeneous mutations in cancer, but their individual druggability remains largely elusive. Here, we evaluated 800 common mutants for rescue potencies the representative generic compound arsenic trioxide (ATO) terms transactivation activity, cell growth inhibition, and mouse tumor–suppressive activities. The were mainly determined solvent accessibility mutated residue, a key factor determining whether mutation structural one, temperature...
Nuclear factor erythroid 2-related 2 (Nrf2) is a key transcription against oxidative stress and neurodegenerative disorders. Phenylethanoid glycosides (PhGs; salidroside, acteoside, isoacteoside, echinacoside) exhibit antioxidant neuroprotective bioactivities. This study was performed to investigate the effect molecular mechanism of PhGs. PhGs pretreatment significantly suppressed H₂O₂-induced cytotoxicity in PC12 cells by triggering nuclear translocation Nrf2 reversing downregulated protein...
Phytosterols are well-known for their cholesterol-lowering effects, and the structures forms of phytosterols affect bioactivity. We aimed to illustrate phytosterol profiles in common foods estimate natural intake five geographical regions among different age groups China. In total, 12 free esterified 119 from across China were examined using gas chromatography–mass spectrometry. Then, dietary was calculated combined with data Chinese people. The total content highest vegetable oils...
The tumor suppressor p53 is inactivated by over hundreds of heterogenous mutations in cancer. Here, we purposefully selected phenotypically reversible temperature-sensitive (TS) for pharmacological rescue with thermostability as the compound-screening readout. This rational screening identified antiparasitic drug potassium antimony tartrate (PAT) an agent that can thermostabilize representative TS mutant p53-V272M via noncovalent binding. PAT met three basic criteria a targeted drug:...
Arsenic trioxide (ATO) targets PML/RARα and leads to miraculous success in treating acute promyelocytic leukemia. Notably, ATO also p53, the most frequently mutated protein cancers, through a similar binding mechanism. However, p53-targeting trials are challenging due poor cellular uptake cancer selectivity of ATO. Here, we analyzed structure–activity relationship arsenicals rationally developed novel arsenical (designated AcGlcAs) by conjugating arsenic sulfur atoms...
Summary: Pharmacologically targeting tumor suppressors necessitates an unprecedented strategy of restoring, rather than conventionally inhibiting, protein function, and p53, the most commonly mutated in cancer, has thus remained undruggable. In this study, we address long-standing misconceptions field gaps scientific logic for a p53 function–restoration strategy, identify four barriers drugging mutant accordingly propose effectiveness evaluation criteria, clinical-translating norms,...
Identifying drugs targeting p53 remains a major focus of precision oncology, with over twenty compounds that can rescue mutants reported. Here, we suggest three easily accessible assays to determine the thermostability, protein folding, and transcriptional activity mutants-the go-to criteria for evaluating compound acts by increasing thermostability. Because diversity mutants, meets one assay does not necessarily meet other assays. For complete details on use execution this protocol, please...
Abstract Li-Fraumeni syndrome (LFS) is characterized by germline mutations occurring on one allele of genome guardian TP53 . It a severe cancer predisposition with poor prognosis, partly due to the frequent development subsequent primary tumors following DNA-damaging therapies. Here we explored, for first time, effectiveness mutant p53 rescue compound in treating LFS-mimicking mice harboring deleterious mutation. Among ten hotspot IARC LFS cohorts, R282W predicting poorest survival prognosis...